Subretinal delivery of immunoglobulin G with gold nanoparticles in the rabbit eye

Purpose To examine the feasibility of subretinal delivery of immunoglobulin G (IgG) adsorbed onto gold nanoparticles (GNPs) and its histologic distribution in the rabbit retina after the injection. Methods Goat IgG was adsorbed onto GNPs electrostatically. Goat IgG-adsorbed GNPs or buffer with goat...

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Veröffentlicht in:	Japanese journal of ophthalmology 2009-05, Vol.53 (3), p.249-256
Hauptverfasser:	Hayashi, Atsushi, Naseri, Ayman, Pennesi, Mark E., de Juan, Eugene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Cell Proliferation - drug effects Drug Delivery Systems Electrophoresis, Polyacrylamide Gel Gold Immunoconjugates - administration & dosage Immunoenzyme Techniques Immunoglobulin G - administration & dosage Laboratory Investigation Medicine Medicine & Public Health Metal Nanoparticles - administration & dosage Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission Ophthalmology Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - ultrastructure Rabbits Retina - drug effects Retina - ultrastructure Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - ultrastructure
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