Study of beta -III tubulin expression in human eye tissues during prenatal development
The expression of beta -III tubulin, a marker protein of early neuronal cells, was studied by molecular genetic and immunochemical techniques. The study was performed with the eyes of human fetuses on weeks 8.5 to 27-28 of intrauterine development. Expression of beta -III tubulin was detected immuno...
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| Veröffentlicht in: | Biology bulletin of the Russian Academy of Sciences 2008-04, Vol.35 (2), p.121-125 |
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| container_title | Biology bulletin of the Russian Academy of Sciences |
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| creator | Panova, I G Markitantova, YuV Firsova, N V Podgornyi, O V Smirnova, YuA Sukhikh, G T Zinovieva, R D Mitashov, VI |
| description | The expression of beta -III tubulin, a marker protein of early neuronal cells, was studied by molecular genetic and immunochemical techniques. The study was performed with the eyes of human fetuses on weeks 8.5 to 27-28 of intrauterine development. Expression of beta -III tubulin was detected immunochemically in the retina and lens fibers of fetuses at stages of 8.5 to 22-23 weeks. By means of PCR, a strong expression of the beta -III tubulin gene was revealed in the retina of 9.5-week fetuses. Its level remained high until week 18, became slightly lower by week 24, and decreased to zero by week 27-28. The expression of this gene was also revealed in the lens of 9.5-week fetuses. Its level at stages of 15 to 24 weeks was very low, and no expression could be detected in 27-to 28-week fetuses. The results of PCR analysis were consistent with immunochemical data. |
| doi_str_mv | 10.1007/s10525-008-2004-x |
| format | Article |
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The study was performed with the eyes of human fetuses on weeks 8.5 to 27-28 of intrauterine development. Expression of beta -III tubulin was detected immunochemically in the retina and lens fibers of fetuses at stages of 8.5 to 22-23 weeks. By means of PCR, a strong expression of the beta -III tubulin gene was revealed in the retina of 9.5-week fetuses. Its level remained high until week 18, became slightly lower by week 24, and decreased to zero by week 27-28. The expression of this gene was also revealed in the lens of 9.5-week fetuses. Its level at stages of 15 to 24 weeks was very low, and no expression could be detected in 27-to 28-week fetuses. 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| title | Study of beta -III tubulin expression in human eye tissues during prenatal development |
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