The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy

Poly(ADP-ribose) polymerase (PARP) plays an important role in a number of cellular processes including DNA repair. Since poly(ADP-ribosyl)ation occurs in response to radiation- or drag-induced DNA damage, inhibitors of the enzyme may enhance the antitumour activity of radiotherapy or cytotoxic drug...

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Veröffentlicht in:	Biochimie 1995, Vol.77 (6), p.408-422
Hauptverfasser:	Griffin, R.J., Curtin, N.J., Newell, D.R., Golding, B.T., Durkacz, B.W., Calvert, A.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer therapy DNA Repair - drug effects Drug Resistance, Neoplasm Drug Synergism Enzyme Inhibitors - therapeutic use Humans inhibitors Molecular Structure Neoplasms - drug therapy Neoplasms - radiotherapy Neoplasms - therapy poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors radiopotentiation resistance-modifying agents Structure-Activity Relationship
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