Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo

γ-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemical...

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Veröffentlicht in:	Metabolic brain disease 2009-06, Vol.24 (2), p.271-282
Hauptverfasser:	Sgaravatti, Ângela M, Magnusson, Alessandra S, Oliveira, Amanda S, Mescka, Caroline P, Zanin, Fernanda, Sgarbi, Mirian B, Pederzolli, Carolina D, Wyse, Angela T. S, Wannmacher, Clóvis M. D, Wajner, Moacir, Dutra-Filho, Carlos S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Butylene Glycols - metabolism Butylene Glycols - pharmacology Catalase - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Dose-Response Relationship, Drug Glutathione Peroxidase - metabolism Hydroxybutyrates - toxicity Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Luminescence Metabolic Diseases Neurology Neurosciences Neurotoxins - toxicity Oncology Original Paper Oxidation-Reduction - drug effects Oxidative Stress - drug effects Oxidative Stress - physiology Prodrugs - metabolism Prodrugs - pharmacology Rats Rats, Wistar Statistics, Nonparametric Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism
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