Protocatechuic acid inhibits apoptosis by mitochondrial dysfunction in rotenone-induced PC12 cells

Protocatechuic acid (PCA), a phenolic compound isolated from the kernels of Alpinia ( A.) oxyphylla, showed the significant neuroprotective effects on hydrogen peroxide (H 2O 2) or MPP +-induced apoptosis in cultured PC12 cells. However, the mechanism how PCA suppresses rotenone-induced neurotoxicit...

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Veröffentlicht in:	Toxicology in vitro 2008-03, Vol.22 (2), p.430-437
Hauptverfasser:	Liu, Ye-Ming, Jiang, Bo, Bao, Yong-Ming, An, Li-Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpinia Animals Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects Caspase 3 - metabolism Cell Nucleus - drug effects Cell Nucleus - ultrastructure Cell Survival - drug effects Dopamine - physiology Flow Cytometry Genes, bcl-2 - drug effects Genes, bcl-2 - genetics Glutathione - metabolism Hydroxybenzoates - pharmacology Membrane Potentials - drug effects Mitochondria - drug effects Mitochondrial dysfunction Necrosis Neurotoxicity Syndromes - pathology PC12 Cells Protocatechuic acid Rats Reactive Oxygen Species - metabolism Rotenone Rotenone - toxicity Uncoupling Agents - toxicity
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