Evaluation of aneugenic effects of bisphenol A in somatic and germ cells of the mouse

Bisphenol A (BPA) is a synthetic monomer widely used to polymerize polycarbonate plastics and resins. It is shown in vitro to interfere with microtubules, producing aberations in mitotic and meiotic spindles. An increase of meiotic abnormalities in untreated female mice from an experimental colony w...

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Veröffentlicht in:	Mutation research 2008-03, Vol.651 (1), p.64-70
Hauptverfasser:	Pacchierotti, F., Ranaldi, R., Eichenlaub-Ritter, U., Attia, S., Adler, I.-D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneugens - toxicity Aneuploidy Animals Benzhydryl Compounds Biological and medical sciences Bisphenol A Chromosome aberrations Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Germ Cells - drug effects Germ Cells - metabolism In Situ Hybridization, Fluorescence Male Medical genetics Medical sciences Meiosis - drug effects Meiosis - genetics Mice Mice, Inbred C57BL Micronucleus Tests - methods Mouse Oocytes Oocytes - drug effects Oocytes - metabolism Phenols - toxicity Polyploidy Sperm-FISH Toxicology Zygote - drug effects Zygote - metabolism Zygotes
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