Interactions between protease inhibitors and acid‐reducing agents: a systematic review
Objective The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid‐reducing agents, and their clinical relevance. Methods A literature search was performed using Medline and EMBASE...
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| Veröffentlicht in: | HIV medicine 2007-09, Vol.8 (6), p.335-345 |
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| container_title | HIV medicine |
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| creator | Béïque, L Giguère, P La Porte, C Angel, J |
| description | Objective
The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid‐reducing agents, and their clinical relevance.
Methods
A literature search was performed using Medline and EMBASE, s of the previous 2 years of major conferences were searched and the drug information service of the manufacturer of every currently available PI was contacted. All data were summarized, and verified by at least two authors.
Results
A total of 1231 references were identified, 22 of which were studies of pharmacokinetic interactions between PIs and acid‐suppressive agents and a further 12 of which provided pharmacokinetic and/or clinical data.
Conclusions
Many pharmacokinetic studies show a lack of a drug interaction between at least one acid‐reducing agent and most PIs. Little clinical information is available, except on interactions between atazanavir and acid‐reducing agents. This is probably a consequence of the complexity of the interaction. |
| doi_str_mv | 10.1111/j.1468-1293.2007.00482.x |
| format | Article |
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The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid‐reducing agents, and their clinical relevance.
Methods
A literature search was performed using Medline and EMBASE, s of the previous 2 years of major conferences were searched and the drug information service of the manufacturer of every currently available PI was contacted. All data were summarized, and verified by at least two authors.
Results
A total of 1231 references were identified, 22 of which were studies of pharmacokinetic interactions between PIs and acid‐suppressive agents and a further 12 of which provided pharmacokinetic and/or clinical data.
Conclusions
Many pharmacokinetic studies show a lack of a drug interaction between at least one acid‐reducing agent and most PIs. Little clinical information is available, except on interactions between atazanavir and acid‐reducing agents. This is probably a consequence of the complexity of the interaction.</description><identifier>ISSN: 1464-2662</identifier><identifier>EISSN: 1468-1293</identifier><identifier>DOI: 10.1111/j.1468-1293.2007.00482.x</identifier><identifier>PMID: 17661841</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>acid‐reducing agents ; antacids ; Antacids - pharmacokinetics ; Antacids - therapeutic use ; Drug Interactions - physiology ; Female ; Histamine Antagonists - pharmacokinetics ; Histamine Antagonists - therapeutic use ; histamine‐2 receptor antagonists ; HIV Infections - blood ; HIV Infections - metabolism ; Human immunodeficiency virus ; Humans ; Male ; protease inhibitors ; Protease Inhibitors - blood ; Protease Inhibitors - pharmacokinetics ; proton pump inhibitors ; Proton Pump Inhibitors - therapeutic use</subject><ispartof>HIV medicine, 2007-09, Vol.8 (6), p.335-345</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4722-fcfeb345d166ea1051642a8152e8707f6f31f66cc2824b80b712085115caf7ef3</citedby><cites>FETCH-LOGICAL-c4722-fcfeb345d166ea1051642a8152e8707f6f31f66cc2824b80b712085115caf7ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1293.2007.00482.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1293.2007.00482.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17661841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Béïque, L</creatorcontrib><creatorcontrib>Giguère, P</creatorcontrib><creatorcontrib>La Porte, C</creatorcontrib><creatorcontrib>Angel, J</creatorcontrib><title>Interactions between protease inhibitors and acid‐reducing agents: a systematic review</title><title>HIV medicine</title><addtitle>HIV Med</addtitle><description>Objective
The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid‐reducing agents, and their clinical relevance.
Methods
A literature search was performed using Medline and EMBASE, s of the previous 2 years of major conferences were searched and the drug information service of the manufacturer of every currently available PI was contacted. All data were summarized, and verified by at least two authors.
Results
A total of 1231 references were identified, 22 of which were studies of pharmacokinetic interactions between PIs and acid‐suppressive agents and a further 12 of which provided pharmacokinetic and/or clinical data.
Conclusions
Many pharmacokinetic studies show a lack of a drug interaction between at least one acid‐reducing agent and most PIs. Little clinical information is available, except on interactions between atazanavir and acid‐reducing agents. This is probably a consequence of the complexity of the interaction.</description><subject>acid‐reducing agents</subject><subject>antacids</subject><subject>Antacids - pharmacokinetics</subject><subject>Antacids - therapeutic use</subject><subject>Drug Interactions - physiology</subject><subject>Female</subject><subject>Histamine Antagonists - pharmacokinetics</subject><subject>Histamine Antagonists - therapeutic use</subject><subject>histamine‐2 receptor antagonists</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - metabolism</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>protease inhibitors</subject><subject>Protease Inhibitors - blood</subject><subject>Protease Inhibitors - pharmacokinetics</subject><subject>proton pump inhibitors</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><issn>1464-2662</issn><issn>1468-1293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1OwzAQhS0EolC4AvKKXYLHSRwXsUEVP5WQ2ABiZznOGFy1SbFd2u44AmfkJKS0gi2zmSfNmzejjxAKLIWuzsYp5EImwAdZyhkrU8ZyydPlDjn4Hez-6DzhQvAeOQxhzBiU2YDtkx6UQoDM4YA8j5qIXpvo2ibQCuMCsaEz30bUAalrXl3lYusD1U1NtXH118enx3puXPNC9Qs2MZxTTcMqRJzq6Az1-O5wcUT2rJ4EPN72Pnm8vnoY3iZ39zej4eVdYvKS88Qai1WWFzUIgRpYASLnWkLBUZastMJmYIUwhkueV5JVJXAmC4DCaFuizfrkdJPb_fw2xxDV1AWDk4lusJ0HxZkoWNZVn8iN0fg2BI9Wzbybar9SwNSaqhqrNTy1hqfWVNUPVbXsVk-2N-bVFOu_xS3GznCxMSzcBFf_Dla3o6dOZN_AJ4c-</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Béïque, L</creator><creator>Giguère, P</creator><creator>La Porte, C</creator><creator>Angel, J</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>200709</creationdate><title>Interactions between protease inhibitors and acid‐reducing agents: a systematic review</title><author>Béïque, L ; Giguère, P ; La Porte, C ; Angel, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4722-fcfeb345d166ea1051642a8152e8707f6f31f66cc2824b80b712085115caf7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>acid‐reducing agents</topic><topic>antacids</topic><topic>Antacids - pharmacokinetics</topic><topic>Antacids - therapeutic use</topic><topic>Drug Interactions - physiology</topic><topic>Female</topic><topic>Histamine Antagonists - pharmacokinetics</topic><topic>Histamine Antagonists - therapeutic use</topic><topic>histamine‐2 receptor antagonists</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - metabolism</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Male</topic><topic>protease inhibitors</topic><topic>Protease Inhibitors - blood</topic><topic>Protease Inhibitors - pharmacokinetics</topic><topic>proton pump inhibitors</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Béïque, L</creatorcontrib><creatorcontrib>Giguère, P</creatorcontrib><creatorcontrib>La Porte, C</creatorcontrib><creatorcontrib>Angel, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>HIV medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Béïque, L</au><au>Giguère, P</au><au>La Porte, C</au><au>Angel, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactions between protease inhibitors and acid‐reducing agents: a systematic review</atitle><jtitle>HIV medicine</jtitle><addtitle>HIV Med</addtitle><date>2007-09</date><risdate>2007</risdate><volume>8</volume><issue>6</issue><spage>335</spage><epage>345</epage><pages>335-345</pages><issn>1464-2662</issn><eissn>1468-1293</eissn><abstract>Objective
The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid‐reducing agents, and their clinical relevance.
Methods
A literature search was performed using Medline and EMBASE, s of the previous 2 years of major conferences were searched and the drug information service of the manufacturer of every currently available PI was contacted. All data were summarized, and verified by at least two authors.
Results
A total of 1231 references were identified, 22 of which were studies of pharmacokinetic interactions between PIs and acid‐suppressive agents and a further 12 of which provided pharmacokinetic and/or clinical data.
Conclusions
Many pharmacokinetic studies show a lack of a drug interaction between at least one acid‐reducing agent and most PIs. Little clinical information is available, except on interactions between atazanavir and acid‐reducing agents. This is probably a consequence of the complexity of the interaction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17661841</pmid><doi>10.1111/j.1468-1293.2007.00482.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | HIV medicine, 2007-09, Vol.8 (6), p.335-345 |
| issn | 1464-2662 1468-1293 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; Wiley Online Library All Journals |
| subjects | acid‐reducing agents antacids Antacids - pharmacokinetics Antacids - therapeutic use Drug Interactions - physiology Female Histamine Antagonists - pharmacokinetics Histamine Antagonists - therapeutic use histamine‐2 receptor antagonists HIV Infections - blood HIV Infections - metabolism Human immunodeficiency virus Humans Male protease inhibitors Protease Inhibitors - blood Protease Inhibitors - pharmacokinetics proton pump inhibitors Proton Pump Inhibitors - therapeutic use |
| title | Interactions between protease inhibitors and acid‐reducing agents: a systematic review |
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