p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation

Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with strenuous contractions of the inspiratory muscles and increased negative intrathoracic pressures that act as an injurious stimulus to the lung. We have shown that IRB induces pulmonary inflammation i...

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Veröffentlicht in:	Inflammation 2018-10, Vol.41 (5), p.1873-1887
Hauptverfasser:	Toumpanakis, Dimitrios, Vassilakopoulou, Vyronia, Mizi, Eleftheria, Chatzianastasiou, Athanasia, Loverdos, Konstantinos, Vraila, Ioanna, Perlikos, Fotis, Tsoukalas, Dionysios, Giannakopoulou, Charoula-Eleni, Sotiriou, Adamantia, Dettoraki, Maria, Karavana, Vassiliki, Vassilakopoulos, Theodoros
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchus Chemokine CXCL2 - analysis Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Imidazoles - pharmacology Immunology Inflammation Inhalation Internal Medicine Kinases Leukocytes (neutrophilic) Lung Injury Macrophages Muscle contraction Neutrophils Original Article p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Pathology Pharmacology/Toxicology Pneumonia - drug therapy Pneumonia - etiology Pyridines - pharmacology Rats Respiration Respiratory system Respiratory tract diseases Rheumatology Tumor Necrosis Factor-alpha - analysis Tumor necrosis factor-α
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