Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps?
Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathog...
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| Veröffentlicht in: | Journal of laryngology and otology 2018-08, Vol.132 (8), p.724-728 |
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| container_title | Journal of laryngology and otology |
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| creator | Ismi, O Kara, T Polat, G Bobusoglu, O Vayısoglu, Y Gorur, K Ozcan, C |
| description | Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.
The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.
Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund-Mackay scores (p = 0.792).
Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation. |
| doi_str_mv | 10.1017/S0022215118000981 |
| format | Article |
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The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.
Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund-Mackay scores (p = 0.792).
Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215118000981</identifier><identifier>PMID: 29974835</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Allergies ; Asthma ; Asthma - complications ; Asthma - metabolism ; Bone ; Brain-derived neurotrophic factor ; Case-Control Studies ; Enzyme-linked immunosorbent assay ; Ethmoid Sinus - metabolism ; Female ; Growth factors ; Humans ; Immunohistochemistry ; Inflammation ; Main Articles ; Male ; Nasal Polyps - etiology ; Nasal Polyps - metabolism ; Nasal Polyps - pathology ; Nerve growth factor ; Nerve Growth Factors - metabolism ; Neuropeptides ; Neurotrophic factors ; Neurotrophin 3 ; Nose ; Otolaryngology ; Pathogenesis ; Polyps ; Serum levels ; Statistical analysis ; Studies ; Surgery ; Turbinates - metabolism</subject><ispartof>Journal of laryngology and otology, 2018-08, Vol.132 (8), p.724-728</ispartof><rights>Copyright © JLO (1984) Limited, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-34d459e2d01dae55ce3d448a59b0549929122a12cd364f449dd1d3d07a72f7c33</citedby><cites>FETCH-LOGICAL-c373t-34d459e2d01dae55ce3d448a59b0549929122a12cd364f449dd1d3d07a72f7c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215118000981/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27915,27916,55619</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29974835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ismi, O</creatorcontrib><creatorcontrib>Kara, T</creatorcontrib><creatorcontrib>Polat, G</creatorcontrib><creatorcontrib>Bobusoglu, O</creatorcontrib><creatorcontrib>Vayısoglu, Y</creatorcontrib><creatorcontrib>Gorur, K</creatorcontrib><creatorcontrib>Ozcan, C</creatorcontrib><title>Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps?</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.
The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.
Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund-Mackay scores (p = 0.792).
Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.</description><subject>Adult</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - metabolism</subject><subject>Bone</subject><subject>Brain-derived neurotrophic factor</subject><subject>Case-Control Studies</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Ethmoid Sinus - metabolism</subject><subject>Female</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Main Articles</subject><subject>Male</subject><subject>Nasal Polyps - etiology</subject><subject>Nasal Polyps - metabolism</subject><subject>Nasal Polyps - pathology</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neuropeptides</subject><subject>Neurotrophic factors</subject><subject>Neurotrophin 3</subject><subject>Nose</subject><subject>Otolaryngology</subject><subject>Pathogenesis</subject><subject>Polyps</subject><subject>Serum levels</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Turbinates - metabolism</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10LtOwzAUBmALgWgpPAALssTCEvA1jieEKi6VkBgAMUZufNKmSu1gJ0PfnoQWkEBMHs53_mP9CJ1SckkJVVfPhDDGqKQ0I4TojO6hMVUiS6RIyT4aD-NkmI_QUYyr3lBF2CEaMa17xuUYvc0ibpcQABu3wVCWULTYl9hBF3wbfLOsXMKxd4PCjWmXfgEOYhU_lXeJqWsIi6rAzkRT48bXmyZeH6OD0tQRTnbvBL3e3b5MH5LHp_vZ9OYxKbjibcKFFVIDs4RaA1IWwK0QmZF6TqTQmmnKmKGssDwVpRDaWmq5JcooVqqC8wm62OY2wb93ENt8XcUC6to48F3MGUmFSpVI056e_6Ir3wXX_65XOtNaSjooulVF8DEGKPMmVGsTNjkl-dB6_qf1fudsl9zN12C_N75q7gHfhZr1PFR2AT-3_4_9AAdmiiI</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Ismi, O</creator><creator>Kara, T</creator><creator>Polat, G</creator><creator>Bobusoglu, O</creator><creator>Vayısoglu, Y</creator><creator>Gorur, K</creator><creator>Ozcan, C</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps?</title><author>Ismi, O ; 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Laryngol. Otol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>132</volume><issue>8</issue><spage>724</spage><epage>728</epage><pages>724-728</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><abstract>Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.
The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.
Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund-Mackay scores (p = 0.792).
Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>29974835</pmid><doi>10.1017/S0022215118000981</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Cambridge Journals - CAUL Collection |
| subjects | Adult Allergies Asthma Asthma - complications Asthma - metabolism Bone Brain-derived neurotrophic factor Case-Control Studies Enzyme-linked immunosorbent assay Ethmoid Sinus - metabolism Female Growth factors Humans Immunohistochemistry Inflammation Main Articles Male Nasal Polyps - etiology Nasal Polyps - metabolism Nasal Polyps - pathology Nerve growth factor Nerve Growth Factors - metabolism Neuropeptides Neurotrophic factors Neurotrophin 3 Nose Otolaryngology Pathogenesis Polyps Serum levels Statistical analysis Studies Surgery Turbinates - metabolism |
| title | Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps? |
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