Activities of naphthoquinones against Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae), vector of dengue and Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni

Larvicidal (against Aedes aegypti Linnaeus, 1762) and molluscicidal (against Biomphalaria glabrata Say, 1818) activities of several natural and synthetic naphthoquinones were measured, with significant results. The best larvicidal compound is 3-bromojuglone, while the better molluscicides are 2-brom...

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Veröffentlicht in:Acta tropica 2009-07, Vol.111 (1), p.44-50
Hauptverfasser: Ribeiro, Karlos A.L., de Carvalho, Cenira Monteiro, Molina, Maria Teresa, Lima, Estelita Pereira, López-Montero, Eulogio, Reys, José Rui M., de Oliveira, Maria Beatriz Farias, Pinto, Antonio Ventura, Santana, Antônio Euzébio G., Goulart, Marília O.F.
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container_issue 1
container_start_page 44
container_title Acta tropica
container_volume 111
creator Ribeiro, Karlos A.L.
de Carvalho, Cenira Monteiro
Molina, Maria Teresa
Lima, Estelita Pereira
López-Montero, Eulogio
Reys, José Rui M.
de Oliveira, Maria Beatriz Farias
Pinto, Antonio Ventura
Santana, Antônio Euzébio G.
Goulart, Marília O.F.
description Larvicidal (against Aedes aegypti Linnaeus, 1762) and molluscicidal (against Biomphalaria glabrata Say, 1818) activities of several natural and synthetic naphthoquinones were measured, with significant results. The best larvicidal compound is 3-bromojuglone, while the better molluscicides are 2-bromo- and 3-bromo-5-acetoxy-1,4-naphthoquinones together with the 3-bromo-5-methoxy derivative. The present results reinforce the potential use of substituted hydroxyquinones, their salts and halogenated quinones as very promising compounds against 4th instar larves of Aedes aegypti, the vector of dengue and against adult snail of Biomphalaria glabrata.
doi_str_mv 10.1016/j.actatropica.2009.02.008
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The best larvicidal compound is 3-bromojuglone, while the better molluscicides are 2-bromo- and 3-bromo-5-acetoxy-1,4-naphthoquinones together with the 3-bromo-5-methoxy derivative. The present results reinforce the potential use of substituted hydroxyquinones, their salts and halogenated quinones as very promising compounds against 4th instar larves of Aedes aegypti, the vector of dengue and against adult snail of Biomphalaria glabrata.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>19426662</pmid><doi>10.1016/j.actatropica.2009.02.008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Aedes - drug effects
Aedes aegypti
Animals
Antiparasitic Agents - chemical synthesis
Antiparasitic Agents - isolation & purification
Antiparasitic Agents - pharmacology
Arboviroses
Biological and medical sciences
Biomphalaria - drug effects
Biomphalaria glabrata
Bromonaphthoquinones
Culicidae
Dengue
Dengue fevers
Diptera
Diseases caused by trematodes
General aspects
Helminthic diseases
Human viral diseases
Infectious diseases
Insecticides - chemical synthesis
Insecticides - isolation & purification
Insecticides - pharmacology
Isolapachol
Juglone
Lapachol
Larvicidal activity
Medical sciences
Mollusca
Naphthoquinones - chemical synthesis
Naphthoquinones - isolation & purification
Naphthoquinones - pharmacology
Parasitic diseases
Schistosoma mansoni
Schistosomiases
Schistosomiasis
Tropical viral diseases
Viral diseases
title Activities of naphthoquinones against Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae), vector of dengue and Biomphalaria glabrata (Say, 1818), intermediate host of Schistosoma mansoni
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