Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

Parkinson's disease is characterized by the selective depletion of dopamine neurons in the substantia nigra, particular those containing neuromelanin. Involvement of neuromelanin in the pathogenesis may be either cytotoxic or protective. Recently we found that neuromelanin reduces the activity...

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Veröffentlicht in:	Journal of Neural Transmission 2006-05, Vol.113 (5), p.633-644
Hauptverfasser:	Shamoto-Nagai, M, Maruyama, W, Yi, H, Akao, Y, Tribl, F, Gerlach, M, Osawa, T, Riederer, P, Naoi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - pharmacology Analysis of Variance Antioxidants - pharmacology Blotting, Western - methods Brain - metabolism Cell Line, Tumor Deferoxamine - pharmacology Dose-Response Relationship, Drug Drug Interactions Humans Iron - metabolism Melanins - pharmacology Mitochondria - drug effects Neuroblastoma Nitric Oxide - metabolism Oxidative Stress - drug effects Proteasome Endopeptidase Complex - physiology Reactive Oxygen Species - metabolism Siderophores - pharmacology Spectrometry, Fluorescence - methods Transfection
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