Association of cytotoxic T-lymphocyte antigen 4 rs231775 gene polymorphism with colorectal cancer risk

Aim of the Study: Results on the relationship between cytotoxic T-lymphocyte antigen 4 (CTLA4) +49A/G (rs231775) gene polymorphism and colorectal cancer risk are still debated. This meta-analysis was performed to assess the association between CTLA4 +49A/G and colorectal cancer risk. Materials and Methods: The relevant studies were searched from PubMed, Cochrane Library, and China Biological Medicine Database-disc, and eligible investigations were included and synthesized using meta-analysis method. Results: Eleven studies were recruited into this meta-analysis for the association of CTLA4 A/G gene polymorphism and colorectal cancer risk, consisting of 1802 colorectal cancer patients and 2939 controls. G allele was a risk factor for the colorectal cancer risk, and AA genotype might be a protective factor against colorectal cancer risk in overall populations (G allele: Odds ratio [OR] = 1.19, 95% confidence interval [CI]: 1.03-1.38, P = 0.02; AA genotype: OR = 0.63, 95% CI: 0.47-0.84, P = 0.002). However, the GG genotype was not associated with colorectal cancer risk in overall populations. Conclusion: The association between CTLA4 G allele/AA genotype and colorectal cancer risk was found in this meta-analysis.