The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence
Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of histone proteins causes transcription of g...
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| Veröffentlicht in: | Anticancer research 2018-07, Vol.38 (7), p.3817-3824 |
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| creator | Moschos, Marilita M Dettoraki, Maria Androudi, Sofia Kalogeropoulos, Dimitrios Lavaris, Anastasios Garmpis, Nikolaos Damaskos, Christos Garmpi, Anna Tsatsos, Michael |
| description | Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of histone proteins causes transcription of genes involved in cell growth, DNA replication and progression of cell cycle. Overexpression of histone deacetylases occurs in a wide spectrum of malignancies. Histone deacetylase inhibitors block the action of histone deacetylases, leading to inhibition of tumor cell proliferation. This article reviewed the potential therapeutic effects of histone deacetylase inhibitors on uveal melanoma. MEDLINE database was used under the key words/phrases: histone deacetylase, inhibitors, uveal melanoma and targeted therapies for uveal melanoma. A total of 47, English articles, not only referring to uveal melanoma, published up to February 2018 were used. Valproic acid, trichostatin A, tenovin-6, depsipeptide, panobinostat (LBH-589), vorinostat (suberanilohydroxamic acid) entinostat (MS-275), quisinostat, NaB, JSL-1, MC1568 and MC1575 are histone deacetylase inhibitors that have demonstrated promising antitumor effects against uveal melanoma. Histone deacetylase inhibitors represent a promising therapeutic approach for the treatment of uveal melanoma. |
| doi_str_mv | 10.21873/anticanres.12665 |
| format | Article |
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Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of histone proteins causes transcription of genes involved in cell growth, DNA replication and progression of cell cycle. Overexpression of histone deacetylases occurs in a wide spectrum of malignancies. Histone deacetylase inhibitors block the action of histone deacetylases, leading to inhibition of tumor cell proliferation. This article reviewed the potential therapeutic effects of histone deacetylase inhibitors on uveal melanoma. MEDLINE database was used under the key words/phrases: histone deacetylase, inhibitors, uveal melanoma and targeted therapies for uveal melanoma. A total of 47, English articles, not only referring to uveal melanoma, published up to February 2018 were used. Valproic acid, trichostatin A, tenovin-6, depsipeptide, panobinostat (LBH-589), vorinostat (suberanilohydroxamic acid) entinostat (MS-275), quisinostat, NaB, JSL-1, MC1568 and MC1575 are histone deacetylase inhibitors that have demonstrated promising antitumor effects against uveal melanoma. Histone deacetylase inhibitors represent a promising therapeutic approach for the treatment of uveal melanoma.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.12665</identifier><identifier>PMID: 29970501</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Acetylation ; Adults ; Anticancer properties ; Antitumor activity ; Cell cycle ; Cell growth ; Cell proliferation ; Chemotherapy ; Deoxyribonucleic acid ; DNA ; DNA biosynthesis ; Histone deacetylase ; Inhibitors ; Malignancy ; Medical prognosis ; Melanoma ; Proteins ; Radiation ; Surgery ; Transcription ; Trichostatin A ; Valproic acid</subject><ispartof>Anticancer research, 2018-07, Vol.38 (7), p.3817-3824</ispartof><rights>Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Jul 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-12868171aa682221be50f61e5e53f229d57528385d91907f1e1a2b839df93cfa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29970501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moschos, Marilita M</creatorcontrib><creatorcontrib>Dettoraki, Maria</creatorcontrib><creatorcontrib>Androudi, Sofia</creatorcontrib><creatorcontrib>Kalogeropoulos, Dimitrios</creatorcontrib><creatorcontrib>Lavaris, Anastasios</creatorcontrib><creatorcontrib>Garmpis, Nikolaos</creatorcontrib><creatorcontrib>Damaskos, Christos</creatorcontrib><creatorcontrib>Garmpi, Anna</creatorcontrib><creatorcontrib>Tsatsos, Michael</creatorcontrib><title>The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of histone proteins causes transcription of genes involved in cell growth, DNA replication and progression of cell cycle. Overexpression of histone deacetylases occurs in a wide spectrum of malignancies. Histone deacetylase inhibitors block the action of histone deacetylases, leading to inhibition of tumor cell proliferation. This article reviewed the potential therapeutic effects of histone deacetylase inhibitors on uveal melanoma. MEDLINE database was used under the key words/phrases: histone deacetylase, inhibitors, uveal melanoma and targeted therapies for uveal melanoma. A total of 47, English articles, not only referring to uveal melanoma, published up to February 2018 were used. Valproic acid, trichostatin A, tenovin-6, depsipeptide, panobinostat (LBH-589), vorinostat (suberanilohydroxamic acid) entinostat (MS-275), quisinostat, NaB, JSL-1, MC1568 and MC1575 are histone deacetylase inhibitors that have demonstrated promising antitumor effects against uveal melanoma. Histone deacetylase inhibitors represent a promising therapeutic approach for the treatment of uveal melanoma.</description><subject>Acetylation</subject><subject>Adults</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Chemotherapy</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA biosynthesis</subject><subject>Histone deacetylase</subject><subject>Inhibitors</subject><subject>Malignancy</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Proteins</subject><subject>Radiation</subject><subject>Surgery</subject><subject>Transcription</subject><subject>Trichostatin A</subject><subject>Valproic acid</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLxDAUhYMoOo7-ADcScOOmmnszaRJ3Mo4PGBXEWZdMe4uVTqJJO-C_tzg-wNXZfOdw-Bg7AnGGYLQ8d75rSucjpTPAPFdbbATaQqaVFNtsJFCJTAuh9th-Sq9C5Lk1cpftobVaKAEj9vD8QvwptMRDzW-b1AVP_IpcSd1H6xLxO__SLJsuxMQbzxdrci2_p9b5sHIXfNrHSL7js3VTkS_pgO3Urk10-J1jtriePU9vs_njzd30cp6VUmOXAZrcgAbncoOIsCQl6hxIkZI1oq2UVmikUZUFK3QNBA6XRtqqtrKsnRyz083uWwzvPaWuWDWppHb4RaFPBYp8gtKimAzoyT_0NfTRD-8KBGmEhsHFQMGGKmNIKVJdvMVm5eJHAaL4kl38yS6-ZA-d4-_lfrmi6rfxY1d-AhK4eu8</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Moschos, Marilita M</creator><creator>Dettoraki, Maria</creator><creator>Androudi, Sofia</creator><creator>Kalogeropoulos, Dimitrios</creator><creator>Lavaris, Anastasios</creator><creator>Garmpis, Nikolaos</creator><creator>Damaskos, Christos</creator><creator>Garmpi, Anna</creator><creator>Tsatsos, Michael</creator><general>International Institute of Anticancer Research</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence</title><author>Moschos, Marilita M ; 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetylation Adults Anticancer properties Antitumor activity Cell cycle Cell growth Cell proliferation Chemotherapy Deoxyribonucleic acid DNA DNA biosynthesis Histone deacetylase Inhibitors Malignancy Medical prognosis Melanoma Proteins Radiation Surgery Transcription Trichostatin A Valproic acid |
| title | The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence |
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