Rubus idaeus L. (red raspberry) blocks UVB-induced MMP production and promotes type I procollagen synthesis via inhibition of MAPK/AP-1, NF-κβ and stimulation of TGF-β/Smad, Nrf2 in normal human dermal fibroblasts

Chronic exposure to ultraviolet (UV) radiation causes photo-oxidation, which in turn results in the upregulation of matrix metalloproteinases (MMPs) and loss of collagen. Rubus idaeus L. (RI), also called red raspberry, is an important cash crop that contains abundant antioxidant compounds. Sanguiin...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2018-08, Vol.185, p.241-253
Hauptverfasser:	Gao, Wei, Wang, Yu-shuai, Hwang, Eunson, Lin, Pei, Bae, Jahyun, Seo, Seul A., Yan, Zhengfei, Yi, Tae-Hoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Antioxidants Antioxidants - chemistry Antioxidants - metabolism Berries Cash crops Cell Line Cell Survival - drug effects Cell Survival - radiation effects Chronic exposure Collagen Collagen Type I - metabolism Dermis - cytology Extracellular signal-regulated kinase Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Growth factors Heme oxygenase (decyclizing) Humans Inflammation Inhibition Inhibitors Interleukin 6 Interleukin-6 - metabolism Interstitial collagenase Kinases MAP kinase Matrix metalloproteinase Matrix metalloproteinases Matrix Metalloproteinases - metabolism Mitogen-Activated Protein Kinases - metabolism NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Normal human dermal fibroblasts Nuclear transfer Oxidation Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Photooxidation Plant Extracts - chemistry Plant Extracts - pharmacology Procollagen Protein kinase Proteins Quinone oxidoreductase Quinones Rubus - chemistry Rubus - metabolism Rubus idaeus Rubus idaeus L Signal Transduction - drug effects Signal Transduction - radiation effects Skin Smad Proteins - metabolism Synthesis Transcription Factor AP-1 - metabolism Transcription factors Transforming Growth Factor beta - metabolism Transforming growth factor-b Type I procollagen Ultraviolet B Ultraviolet radiation Ultraviolet Rays
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