In vivo biocompatibility and biomineralization of calcium silicate cements
A new mineral trioxide aggregate (MTA) material has been developed with a modified composition that requires investigations to support its clinical use. This study evaluated the biocompatibility and biomineralization of this new MTA material and compared it with that of two other MTA cements over ti...
Gespeichert in:
| Veröffentlicht in: | European journal of oral sciences 2018-08, Vol.126 (4), p.326-333 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 333 |
|---|---|
| container_issue | 4 |
| container_start_page | 326 |
| container_title | European journal of oral sciences |
| container_volume | 126 |
| creator | Benetti, Francine Gomes‐Filho, João E. Araújo Lopes, Juliana M. Barbosa, Jéssica G. Jacinto, Rogério C. Cintra, Luciano T. A. |
| description | A new mineral trioxide aggregate (MTA) material has been developed with a modified composition that requires investigations to support its clinical use. This study evaluated the biocompatibility and biomineralization of this new MTA material and compared it with that of two other MTA cements over time. Tubes containing materials (or empty tubes as controls) were inserted into the subcutaneous tissues of 40 rats. On days 7, 15, 30, 60, and 90, the tubes were removed with the surrounding tissues, which were either stained with haematoxylin and eosin or von Kossa for further analyses or unstained for observation under polarized light. On days 7 and 15, moderate inflammation was observed in most specimens, and the fibrous capsule was thick. On day 30, there was mild inflammation in all groups, and the fibrous capsule was thin. On days 60 and 90, there was mild inflammation in the material groups, while the control group showed no inflammation, although no statistically significant difference between the groups was observed and the fibrous capsule was thin. All material groups showed structures that stained with von Kossa and could be observed under polarized light; this was not found for the control. In conclusion, the new MTA material had biocompatibility and biomineralization properties similar to those of the two existing MTA materials. |
| doi_str_mv | 10.1111/eos.12539 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2063716834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2063716834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-9f3dd1dfda02fc336213d3ccfbcf34cbc1c3d9e70a692f62b9f3aa00b24bcbdf3</originalsourceid><addsrcrecordid>eNp10E9LwzAYBvAgipvTg19ACl700C1_arscZUydDHZQzyF5k0BG28ymncxPb2anB8FcAnl_eXh5ELokeEzimRgfxoTeMX6EhiTHOMUFpcdoiDnm6XTK8gE6C2GNMWGEF6doQDnPCefZED0v6mTrtj5RzoOvNrJ1ypWu3SWy1vvHytWmkaX7jBNfJ94mIEtwXZWE6EC2JgFTmboN5-jEyjKYi8M9Qm8P89fZU7pcPS5m98sUWFwx5ZZpTbTVElMLjOWUMM0ArALLMlBAgGluCixzTm1OVfwgJcaKZgqUtmyEbvrcTePfOxNaUbkApixlbXwXBMU5K0g-ZVmk13_o2ndNHbfbK055gQmJ6rZX0PgQGmPFpnGVbHaCYLEvWMSCxXfB0V4dEjtVGf0rfxqNYNKDD1ea3f9JYr566SO_AIPehf4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2069297011</pqid></control><display><type>article</type><title>In vivo biocompatibility and biomineralization of calcium silicate cements</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Benetti, Francine ; Gomes‐Filho, João E. ; Araújo Lopes, Juliana M. ; Barbosa, Jéssica G. ; Jacinto, Rogério C. ; Cintra, Luciano T. A.</creator><creatorcontrib>Benetti, Francine ; Gomes‐Filho, João E. ; Araújo Lopes, Juliana M. ; Barbosa, Jéssica G. ; Jacinto, Rogério C. ; Cintra, Luciano T. A.</creatorcontrib><description>A new mineral trioxide aggregate (MTA) material has been developed with a modified composition that requires investigations to support its clinical use. This study evaluated the biocompatibility and biomineralization of this new MTA material and compared it with that of two other MTA cements over time. Tubes containing materials (or empty tubes as controls) were inserted into the subcutaneous tissues of 40 rats. On days 7, 15, 30, 60, and 90, the tubes were removed with the surrounding tissues, which were either stained with haematoxylin and eosin or von Kossa for further analyses or unstained for observation under polarized light. On days 7 and 15, moderate inflammation was observed in most specimens, and the fibrous capsule was thick. On day 30, there was mild inflammation in all groups, and the fibrous capsule was thin. On days 60 and 90, there was mild inflammation in the material groups, while the control group showed no inflammation, although no statistically significant difference between the groups was observed and the fibrous capsule was thin. All material groups showed structures that stained with von Kossa and could be observed under polarized light; this was not found for the control. In conclusion, the new MTA material had biocompatibility and biomineralization properties similar to those of the two existing MTA materials.</description><identifier>ISSN: 0909-8836</identifier><identifier>EISSN: 1600-0722</identifier><identifier>DOI: 10.1111/eos.12539</identifier><identifier>PMID: 29961994</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aluminum Compounds - pharmacology ; Animals ; Biocompatibility ; Biocompatible Materials - pharmacology ; Biomineralization - drug effects ; Bismuth ; Calcium ; Calcium Compounds - pharmacology ; Calcium silicates ; Cements ; Dental cement ; dental cements ; Dental Cements - pharmacology ; dental materials ; Dentistry ; Drug Combinations ; Drug Implants ; endodontics ; Inflammation ; Male ; mineral trioxide aggregate ; Mineralization ; Oxides - pharmacology ; Polarized light ; Rats ; Rats, Wistar ; Silicates - pharmacology ; Statistical analysis ; Subcutaneous Tissue - drug effects ; Tissues ; Tubes</subject><ispartof>European journal of oral sciences, 2018-08, Vol.126 (4), p.326-333</ispartof><rights>2018 Eur J Oral Sci</rights><rights>2018 Eur J Oral Sci.</rights><rights>Copyright © 2018 European Journal of Oral Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-9f3dd1dfda02fc336213d3ccfbcf34cbc1c3d9e70a692f62b9f3aa00b24bcbdf3</citedby><cites>FETCH-LOGICAL-c3539-9f3dd1dfda02fc336213d3ccfbcf34cbc1c3d9e70a692f62b9f3aa00b24bcbdf3</cites><orcidid>0000-0002-5459-353X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feos.12539$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feos.12539$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29961994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benetti, Francine</creatorcontrib><creatorcontrib>Gomes‐Filho, João E.</creatorcontrib><creatorcontrib>Araújo Lopes, Juliana M.</creatorcontrib><creatorcontrib>Barbosa, Jéssica G.</creatorcontrib><creatorcontrib>Jacinto, Rogério C.</creatorcontrib><creatorcontrib>Cintra, Luciano T. A.</creatorcontrib><title>In vivo biocompatibility and biomineralization of calcium silicate cements</title><title>European journal of oral sciences</title><addtitle>Eur J Oral Sci</addtitle><description>A new mineral trioxide aggregate (MTA) material has been developed with a modified composition that requires investigations to support its clinical use. This study evaluated the biocompatibility and biomineralization of this new MTA material and compared it with that of two other MTA cements over time. Tubes containing materials (or empty tubes as controls) were inserted into the subcutaneous tissues of 40 rats. On days 7, 15, 30, 60, and 90, the tubes were removed with the surrounding tissues, which were either stained with haematoxylin and eosin or von Kossa for further analyses or unstained for observation under polarized light. On days 7 and 15, moderate inflammation was observed in most specimens, and the fibrous capsule was thick. On day 30, there was mild inflammation in all groups, and the fibrous capsule was thin. On days 60 and 90, there was mild inflammation in the material groups, while the control group showed no inflammation, although no statistically significant difference between the groups was observed and the fibrous capsule was thin. All material groups showed structures that stained with von Kossa and could be observed under polarized light; this was not found for the control. In conclusion, the new MTA material had biocompatibility and biomineralization properties similar to those of the two existing MTA materials.</description><subject>Aluminum Compounds - pharmacology</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomineralization - drug effects</subject><subject>Bismuth</subject><subject>Calcium</subject><subject>Calcium Compounds - pharmacology</subject><subject>Calcium silicates</subject><subject>Cements</subject><subject>Dental cement</subject><subject>dental cements</subject><subject>Dental Cements - pharmacology</subject><subject>dental materials</subject><subject>Dentistry</subject><subject>Drug Combinations</subject><subject>Drug Implants</subject><subject>endodontics</subject><subject>Inflammation</subject><subject>Male</subject><subject>mineral trioxide aggregate</subject><subject>Mineralization</subject><subject>Oxides - pharmacology</subject><subject>Polarized light</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Silicates - pharmacology</subject><subject>Statistical analysis</subject><subject>Subcutaneous Tissue - drug effects</subject><subject>Tissues</subject><subject>Tubes</subject><issn>0909-8836</issn><issn>1600-0722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9LwzAYBvAgipvTg19ACl700C1_arscZUydDHZQzyF5k0BG28ymncxPb2anB8FcAnl_eXh5ELokeEzimRgfxoTeMX6EhiTHOMUFpcdoiDnm6XTK8gE6C2GNMWGEF6doQDnPCefZED0v6mTrtj5RzoOvNrJ1ypWu3SWy1vvHytWmkaX7jBNfJ94mIEtwXZWE6EC2JgFTmboN5-jEyjKYi8M9Qm8P89fZU7pcPS5m98sUWFwx5ZZpTbTVElMLjOWUMM0ArALLMlBAgGluCixzTm1OVfwgJcaKZgqUtmyEbvrcTePfOxNaUbkApixlbXwXBMU5K0g-ZVmk13_o2ndNHbfbK055gQmJ6rZX0PgQGmPFpnGVbHaCYLEvWMSCxXfB0V4dEjtVGf0rfxqNYNKDD1ea3f9JYr566SO_AIPehf4</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Benetti, Francine</creator><creator>Gomes‐Filho, João E.</creator><creator>Araújo Lopes, Juliana M.</creator><creator>Barbosa, Jéssica G.</creator><creator>Jacinto, Rogério C.</creator><creator>Cintra, Luciano T. A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5459-353X</orcidid></search><sort><creationdate>201808</creationdate><title>In vivo biocompatibility and biomineralization of calcium silicate cements</title><author>Benetti, Francine ; Gomes‐Filho, João E. ; Araújo Lopes, Juliana M. ; Barbosa, Jéssica G. ; Jacinto, Rogério C. ; Cintra, Luciano T. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-9f3dd1dfda02fc336213d3ccfbcf34cbc1c3d9e70a692f62b9f3aa00b24bcbdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aluminum Compounds - pharmacology</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biomineralization - drug effects</topic><topic>Bismuth</topic><topic>Calcium</topic><topic>Calcium Compounds - pharmacology</topic><topic>Calcium silicates</topic><topic>Cements</topic><topic>Dental cement</topic><topic>dental cements</topic><topic>Dental Cements - pharmacology</topic><topic>dental materials</topic><topic>Dentistry</topic><topic>Drug Combinations</topic><topic>Drug Implants</topic><topic>endodontics</topic><topic>Inflammation</topic><topic>Male</topic><topic>mineral trioxide aggregate</topic><topic>Mineralization</topic><topic>Oxides - pharmacology</topic><topic>Polarized light</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Silicates - pharmacology</topic><topic>Statistical analysis</topic><topic>Subcutaneous Tissue - drug effects</topic><topic>Tissues</topic><topic>Tubes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benetti, Francine</creatorcontrib><creatorcontrib>Gomes‐Filho, João E.</creatorcontrib><creatorcontrib>Araújo Lopes, Juliana M.</creatorcontrib><creatorcontrib>Barbosa, Jéssica G.</creatorcontrib><creatorcontrib>Jacinto, Rogério C.</creatorcontrib><creatorcontrib>Cintra, Luciano T. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of oral sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benetti, Francine</au><au>Gomes‐Filho, João E.</au><au>Araújo Lopes, Juliana M.</au><au>Barbosa, Jéssica G.</au><au>Jacinto, Rogério C.</au><au>Cintra, Luciano T. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo biocompatibility and biomineralization of calcium silicate cements</atitle><jtitle>European journal of oral sciences</jtitle><addtitle>Eur J Oral Sci</addtitle><date>2018-08</date><risdate>2018</risdate><volume>126</volume><issue>4</issue><spage>326</spage><epage>333</epage><pages>326-333</pages><issn>0909-8836</issn><eissn>1600-0722</eissn><abstract>A new mineral trioxide aggregate (MTA) material has been developed with a modified composition that requires investigations to support its clinical use. This study evaluated the biocompatibility and biomineralization of this new MTA material and compared it with that of two other MTA cements over time. Tubes containing materials (or empty tubes as controls) were inserted into the subcutaneous tissues of 40 rats. On days 7, 15, 30, 60, and 90, the tubes were removed with the surrounding tissues, which were either stained with haematoxylin and eosin or von Kossa for further analyses or unstained for observation under polarized light. On days 7 and 15, moderate inflammation was observed in most specimens, and the fibrous capsule was thick. On day 30, there was mild inflammation in all groups, and the fibrous capsule was thin. On days 60 and 90, there was mild inflammation in the material groups, while the control group showed no inflammation, although no statistically significant difference between the groups was observed and the fibrous capsule was thin. All material groups showed structures that stained with von Kossa and could be observed under polarized light; this was not found for the control. In conclusion, the new MTA material had biocompatibility and biomineralization properties similar to those of the two existing MTA materials.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29961994</pmid><doi>10.1111/eos.12539</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5459-353X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0909-8836 |
| ispartof | European journal of oral sciences, 2018-08, Vol.126 (4), p.326-333 |
| issn | 0909-8836 1600-0722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2063716834 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aluminum Compounds - pharmacology Animals Biocompatibility Biocompatible Materials - pharmacology Biomineralization - drug effects Bismuth Calcium Calcium Compounds - pharmacology Calcium silicates Cements Dental cement dental cements Dental Cements - pharmacology dental materials Dentistry Drug Combinations Drug Implants endodontics Inflammation Male mineral trioxide aggregate Mineralization Oxides - pharmacology Polarized light Rats Rats, Wistar Silicates - pharmacology Statistical analysis Subcutaneous Tissue - drug effects Tissues Tubes |
| title | In vivo biocompatibility and biomineralization of calcium silicate cements |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T23%3A41%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%20biocompatibility%20and%20biomineralization%20of%20calcium%20silicate%20cements&rft.jtitle=European%20journal%20of%20oral%20sciences&rft.au=Benetti,%20Francine&rft.date=2018-08&rft.volume=126&rft.issue=4&rft.spage=326&rft.epage=333&rft.pages=326-333&rft.issn=0909-8836&rft.eissn=1600-0722&rft_id=info:doi/10.1111/eos.12539&rft_dat=%3Cproquest_cross%3E2063716834%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2069297011&rft_id=info:pmid/29961994&rfr_iscdi=true |