Decoration of virus-like particles with an enzymatic activity of biomedical interest

[Display omitted] •SpyTag and SpyCatcher system was used to display an α-glucosidase on the surface of VLPs.•Conjugation of the enzyme to the VLP did not block its catalytic activity.•α-Glucosidase activity was biochemically characterized.•VLPs displaying α-glucosidase activity were structurally cha...

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Veröffentlicht in:	Virus research 2018-08, Vol.255, p.1-9
Hauptverfasser:	Cayetano-Cruz, Maribel, Coffeen, Carlos Francisco, Valadez-García, Josefina, Montiel, Carmina, Bustos-Jaimes, Ismael
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - chemistry alpha-Glucosidases - genetics alpha-Glucosidases - metabolism Capsid Proteins - chemistry Capsid Proteins - genetics Capsid Proteins - metabolism Drug Delivery Systems - methods Glucosides - metabolism Glycogen - metabolism Hydrogen-Ion Concentration In vitro self-assembly Kinetics Lysosomal storage diseases Nanoparticles - chemistry Nanoparticles - metabolism Nanoparticles - ultrastructure Particle Size Parvovirus B19 Parvovirus B19, Human - chemistry Parvovirus B19, Human - genetics Parvovirus B19, Human - metabolism Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism SpyTag/SpyCatcher Temperature Virus Assembly Virus-like particles
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