Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma
Background Tumor‐associated neutrophils (TAN), matrix metalloproteinase‐9 (MMP‐9), interleukin‐17 (IL‐17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2018-10, Vol.47 (9), p.856-863 |
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| creator | Silva, Ricardo Natã Fonseca Dallarmi, Laís Bueno Araujo, Ana Karoline Carvalho Alencar, Rita Cassia Gonçalves Mendonça, Elismauro Francisco Silva, Tarcília Aparecida Batista, Aline Carvalho Costa, Nadia Lago |
| description | Background
Tumor‐associated neutrophils (TAN), matrix metalloproteinase‐9 (MMP‐9), interleukin‐17 (IL‐17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC).
Methods
Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP‐9, IL‐17, and CD105 (neoformed microvessels). Semiquantitative (IL‐17) and quantitative (CD66b, IL‐17, MMP‐9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained.
Results
Positivity for TAN, MMP‐9, IL‐17, and CD105 was higher in OSCC than in the negative control (P |
| doi_str_mv | 10.1111/jop.12762 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2063714138</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2063714138</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-57bc79d4dd58b719440d8c22725956359a87ab438b2a9d1f1421ed19f7eceb143</originalsourceid><addsrcrecordid>eNp1kUFvFCEYhonR2HX14B8wJF402Wn5gBmGY9NUrWlSD3qeMAyTZYVhCoO6t_4E40_0l8i61YOJXDjw8Hxv3g-h50BOoZyzXZhPgYqGPkAraAipiAD-EK2IJLyiNdAT9CSlHSEgGIfH6IRK2XBGYIV-XHmfp7C1aQl6a7zVymE1KbdPNuEw4snkJYZ5a13aYDstJjqTP9vp5913EBvs1RLtN-zNopwLcwyLsZNKpjzLTRENRRDGEL0Z8BeTknGpWHCIZUy6zcqHnLA2zmGtorZT8OopejQql8yz-3uNPr25_Hjxrrq-eXt1cX5daVYzWtWi10IOfBjqthcgOSdDqykVtJZ1w2qpWqF6ztqeKjnACJyCGUCOwmjTA2dr9OroLalvs0lL5206RFElck4dJQ0rPQJrC_ryH3QXciwtFQpKqSAPI9fo9ZHSMaQUzdjN0XoV9x2Q7rCo8mvufi-qsC_ujbkv3fwl_2ymAGdH4Kt1Zv9_U_f-5sNR-QvO9aDL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2117319956</pqid></control><display><type>article</type><title>Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Silva, Ricardo Natã Fonseca ; Dallarmi, Laís Bueno ; Araujo, Ana Karoline Carvalho ; Alencar, Rita Cassia Gonçalves ; Mendonça, Elismauro Francisco ; Silva, Tarcília Aparecida ; Batista, Aline Carvalho ; Costa, Nadia Lago</creator><creatorcontrib>Silva, Ricardo Natã Fonseca ; Dallarmi, Laís Bueno ; Araujo, Ana Karoline Carvalho ; Alencar, Rita Cassia Gonçalves ; Mendonça, Elismauro Francisco ; Silva, Tarcília Aparecida ; Batista, Aline Carvalho ; Costa, Nadia Lago</creatorcontrib><description>Background
Tumor‐associated neutrophils (TAN), matrix metalloproteinase‐9 (MMP‐9), interleukin‐17 (IL‐17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC).
Methods
Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP‐9, IL‐17, and CD105 (neoformed microvessels). Semiquantitative (IL‐17) and quantitative (CD66b, IL‐17, MMP‐9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained.
Results
Positivity for TAN, MMP‐9, IL‐17, and CD105 was higher in OSCC than in the negative control (P < 0.05) and oral leukoplakia, but similar to the positive inflammatory control. Coincident high counts of inflammatory markers (CD66b, MMP‐9, IL‐17, and CD105) were associated with lymph node metastasis of OSCC. Associations between high numbers of neoformed microvessels and advanced clinical stage and a higher degree of malignancy were also demonstrated.
Conclusions
Combined positivity for TAN, MMP‐9, IL‐17, and CD105 appears to be associated with the metastasis‐prone phenotype of OSCC.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.12762</identifier><identifier>PMID: 29964301</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adult ; Angiogenesis ; Antigens, CD - analysis ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - diagnosis ; CD105 antigen ; Cell Adhesion Molecules - analysis ; Cytokines ; Dentistry ; Endoglin - analysis ; Female ; GPI-Linked Proteins - analysis ; Granuloma ; Humans ; Immunohistochemistry - methods ; Inflammation ; Interleukin-17 - analysis ; interleukin‐17 ; Leukocytes (neutrophilic) ; Leukokeratosis ; Lymph nodes ; Male ; Malignancy ; Matrix metalloproteinase ; Matrix Metalloproteinase 9 - analysis ; Medical prognosis ; Metalloproteinase ; Metastases ; Metastasis ; Middle Aged ; Mouth Neoplasms - blood supply ; Mouth Neoplasms - diagnosis ; Mucosa ; Neovascularization, Pathologic ; Neutrophils ; Neutrophils - pathology ; Oral cancer ; Oral squamous cell carcinoma ; Phenotypes ; Prognosis ; Squamous cell carcinoma ; Tumors</subject><ispartof>Journal of oral pathology & medicine, 2018-10, Vol.47 (9), p.856-863</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-57bc79d4dd58b719440d8c22725956359a87ab438b2a9d1f1421ed19f7eceb143</citedby><cites>FETCH-LOGICAL-c3532-57bc79d4dd58b719440d8c22725956359a87ab438b2a9d1f1421ed19f7eceb143</cites><orcidid>0000-0002-2117-5593 ; 0000-0001-9623-7835 ; 0000-0002-6751-3279 ; 0000-0002-6463-389X ; 0000-0003-0198-5828</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.12762$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.12762$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29964301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Ricardo Natã Fonseca</creatorcontrib><creatorcontrib>Dallarmi, Laís Bueno</creatorcontrib><creatorcontrib>Araujo, Ana Karoline Carvalho</creatorcontrib><creatorcontrib>Alencar, Rita Cassia Gonçalves</creatorcontrib><creatorcontrib>Mendonça, Elismauro Francisco</creatorcontrib><creatorcontrib>Silva, Tarcília Aparecida</creatorcontrib><creatorcontrib>Batista, Aline Carvalho</creatorcontrib><creatorcontrib>Costa, Nadia Lago</creatorcontrib><title>Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background
Tumor‐associated neutrophils (TAN), matrix metalloproteinase‐9 (MMP‐9), interleukin‐17 (IL‐17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC).
Methods
Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP‐9, IL‐17, and CD105 (neoformed microvessels). Semiquantitative (IL‐17) and quantitative (CD66b, IL‐17, MMP‐9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained.
Results
Positivity for TAN, MMP‐9, IL‐17, and CD105 was higher in OSCC than in the negative control (P < 0.05) and oral leukoplakia, but similar to the positive inflammatory control. Coincident high counts of inflammatory markers (CD66b, MMP‐9, IL‐17, and CD105) were associated with lymph node metastasis of OSCC. Associations between high numbers of neoformed microvessels and advanced clinical stage and a higher degree of malignancy were also demonstrated.
Conclusions
Combined positivity for TAN, MMP‐9, IL‐17, and CD105 appears to be associated with the metastasis‐prone phenotype of OSCC.</description><subject>Adult</subject><subject>Angiogenesis</subject><subject>Antigens, CD - analysis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>CD105 antigen</subject><subject>Cell Adhesion Molecules - analysis</subject><subject>Cytokines</subject><subject>Dentistry</subject><subject>Endoglin - analysis</subject><subject>Female</subject><subject>GPI-Linked Proteins - analysis</subject><subject>Granuloma</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Inflammation</subject><subject>Interleukin-17 - analysis</subject><subject>interleukin‐17</subject><subject>Leukocytes (neutrophilic)</subject><subject>Leukokeratosis</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Malignancy</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 9 - analysis</subject><subject>Medical prognosis</subject><subject>Metalloproteinase</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - blood supply</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mucosa</subject><subject>Neovascularization, Pathologic</subject><subject>Neutrophils</subject><subject>Neutrophils - pathology</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Phenotypes</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Tumors</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFvFCEYhonR2HX14B8wJF402Wn5gBmGY9NUrWlSD3qeMAyTZYVhCoO6t_4E40_0l8i61YOJXDjw8Hxv3g-h50BOoZyzXZhPgYqGPkAraAipiAD-EK2IJLyiNdAT9CSlHSEgGIfH6IRK2XBGYIV-XHmfp7C1aQl6a7zVymE1KbdPNuEw4snkJYZ5a13aYDstJjqTP9vp5913EBvs1RLtN-zNopwLcwyLsZNKpjzLTRENRRDGEL0Z8BeTknGpWHCIZUy6zcqHnLA2zmGtorZT8OopejQql8yz-3uNPr25_Hjxrrq-eXt1cX5daVYzWtWi10IOfBjqthcgOSdDqykVtJZ1w2qpWqF6ztqeKjnACJyCGUCOwmjTA2dr9OroLalvs0lL5206RFElck4dJQ0rPQJrC_ryH3QXciwtFQpKqSAPI9fo9ZHSMaQUzdjN0XoV9x2Q7rCo8mvufi-qsC_ujbkv3fwl_2ymAGdH4Kt1Zv9_U_f-5sNR-QvO9aDL</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Silva, Ricardo Natã Fonseca</creator><creator>Dallarmi, Laís Bueno</creator><creator>Araujo, Ana Karoline Carvalho</creator><creator>Alencar, Rita Cassia Gonçalves</creator><creator>Mendonça, Elismauro Francisco</creator><creator>Silva, Tarcília Aparecida</creator><creator>Batista, Aline Carvalho</creator><creator>Costa, Nadia Lago</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2117-5593</orcidid><orcidid>https://orcid.org/0000-0001-9623-7835</orcidid><orcidid>https://orcid.org/0000-0002-6751-3279</orcidid><orcidid>https://orcid.org/0000-0002-6463-389X</orcidid><orcidid>https://orcid.org/0000-0003-0198-5828</orcidid></search><sort><creationdate>201810</creationdate><title>Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma</title><author>Silva, Ricardo Natã Fonseca ; Dallarmi, Laís Bueno ; Araujo, Ana Karoline Carvalho ; Alencar, Rita Cassia Gonçalves ; Mendonça, Elismauro Francisco ; Silva, Tarcília Aparecida ; Batista, Aline Carvalho ; Costa, Nadia Lago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-57bc79d4dd58b719440d8c22725956359a87ab438b2a9d1f1421ed19f7eceb143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Angiogenesis</topic><topic>Antigens, CD - analysis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>CD105 antigen</topic><topic>Cell Adhesion Molecules - analysis</topic><topic>Cytokines</topic><topic>Dentistry</topic><topic>Endoglin - analysis</topic><topic>Female</topic><topic>GPI-Linked Proteins - analysis</topic><topic>Granuloma</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Inflammation</topic><topic>Interleukin-17 - analysis</topic><topic>interleukin‐17</topic><topic>Leukocytes (neutrophilic)</topic><topic>Leukokeratosis</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Malignancy</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 9 - analysis</topic><topic>Medical prognosis</topic><topic>Metalloproteinase</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - blood supply</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mucosa</topic><topic>Neovascularization, Pathologic</topic><topic>Neutrophils</topic><topic>Neutrophils - pathology</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Phenotypes</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Ricardo Natã Fonseca</creatorcontrib><creatorcontrib>Dallarmi, Laís Bueno</creatorcontrib><creatorcontrib>Araujo, Ana Karoline Carvalho</creatorcontrib><creatorcontrib>Alencar, Rita Cassia Gonçalves</creatorcontrib><creatorcontrib>Mendonça, Elismauro Francisco</creatorcontrib><creatorcontrib>Silva, Tarcília Aparecida</creatorcontrib><creatorcontrib>Batista, Aline Carvalho</creatorcontrib><creatorcontrib>Costa, Nadia Lago</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Ricardo Natã Fonseca</au><au>Dallarmi, Laís Bueno</au><au>Araujo, Ana Karoline Carvalho</au><au>Alencar, Rita Cassia Gonçalves</au><au>Mendonça, Elismauro Francisco</au><au>Silva, Tarcília Aparecida</au><au>Batista, Aline Carvalho</au><au>Costa, Nadia Lago</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2018-10</date><risdate>2018</risdate><volume>47</volume><issue>9</issue><spage>856</spage><epage>863</epage><pages>856-863</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background
Tumor‐associated neutrophils (TAN), matrix metalloproteinase‐9 (MMP‐9), interleukin‐17 (IL‐17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC).
Methods
Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP‐9, IL‐17, and CD105 (neoformed microvessels). Semiquantitative (IL‐17) and quantitative (CD66b, IL‐17, MMP‐9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained.
Results
Positivity for TAN, MMP‐9, IL‐17, and CD105 was higher in OSCC than in the negative control (P < 0.05) and oral leukoplakia, but similar to the positive inflammatory control. Coincident high counts of inflammatory markers (CD66b, MMP‐9, IL‐17, and CD105) were associated with lymph node metastasis of OSCC. Associations between high numbers of neoformed microvessels and advanced clinical stage and a higher degree of malignancy were also demonstrated.
Conclusions
Combined positivity for TAN, MMP‐9, IL‐17, and CD105 appears to be associated with the metastasis‐prone phenotype of OSCC.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29964301</pmid><doi>10.1111/jop.12762</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2117-5593</orcidid><orcidid>https://orcid.org/0000-0001-9623-7835</orcidid><orcidid>https://orcid.org/0000-0002-6751-3279</orcidid><orcidid>https://orcid.org/0000-0002-6463-389X</orcidid><orcidid>https://orcid.org/0000-0003-0198-5828</orcidid></addata></record> |
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| subjects | Adult Angiogenesis Antigens, CD - analysis Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - diagnosis CD105 antigen Cell Adhesion Molecules - analysis Cytokines Dentistry Endoglin - analysis Female GPI-Linked Proteins - analysis Granuloma Humans Immunohistochemistry - methods Inflammation Interleukin-17 - analysis interleukin‐17 Leukocytes (neutrophilic) Leukokeratosis Lymph nodes Male Malignancy Matrix metalloproteinase Matrix Metalloproteinase 9 - analysis Medical prognosis Metalloproteinase Metastases Metastasis Middle Aged Mouth Neoplasms - blood supply Mouth Neoplasms - diagnosis Mucosa Neovascularization, Pathologic Neutrophils Neutrophils - pathology Oral cancer Oral squamous cell carcinoma Phenotypes Prognosis Squamous cell carcinoma Tumors |
| title | Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma |
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