Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions
The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2'-deoxy-5-iodouridine (5...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2018, Vol.54 (57), p.8003-8006 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8006 |
|---|---|
| container_issue | 57 |
| container_start_page | 8003 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 54 |
| creator | Ejlersen, Maria Lou, Chenguang Sanghvi, Yogesh S Tor, Yitzhak Wengel, Jesper |
| description | The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2'-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points. |
| doi_str_mv | 10.1039/c8cc01360h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2063710895</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2063710895</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-1abe4467941e32d96f0bb1b94751ceaee82a34cb50b93f035c815dd304131f0a3</originalsourceid><addsrcrecordid>eNpdkF9LwzAUxYMobk5f_ABS8EWEatIkbfIoZTphIvgHfCtJms7MtplNA85Pb7pNH7wv53L5cTj3AHCK4BWCmF8rphREOIXve2AclMSUsLf9Yac8zjChI3Dk3BKGQZQdglHCeZpxlIzB04MtTWWU6I1tI1tFtjYLW2r7tW69qrXtTaldJNeRbWNla9-00bP_9h8mUp11Ltz8qjbtIuq0UIOJOwYHlaidPtnpBLzeTl_yWTx_vLvPb-axIijrYySkJiTEIEjjpORpBaVEkpOMIqWF1iwRmChJoeS4gpgqhmhZYkgQRhUUeAIutr6rzn567fqiMU7puhattt4VCUxxhiDjNKDn_9Cl9V0b0g0UIxmkKQnU5ZbafNbpqlh1phHdukCwGJoucpbnm6ZnAT7bWXrZ6PIP_a0W_wCrIHk1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2068470564</pqid></control><display><type>article</type><title>Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Ejlersen, Maria ; Lou, Chenguang ; Sanghvi, Yogesh S ; Tor, Yitzhak ; Wengel, Jesper</creator><creatorcontrib>Ejlersen, Maria ; Lou, Chenguang ; Sanghvi, Yogesh S ; Tor, Yitzhak ; Wengel, Jesper</creatorcontrib><description>The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2'-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c8cc01360h</identifier><identifier>PMID: 29967912</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Boronic Acids - chemistry ; Catalysis ; Chemical reactions ; Coupling ; Cross coupling ; Idoxuridine - analogs & derivatives ; Idoxuridine - chemistry ; Oligodeoxyribonucleotides - chemistry ; Oligonucleotides ; Palladium - chemistry</subject><ispartof>Chemical communications (Cambridge, England), 2018, Vol.54 (57), p.8003-8006</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1abe4467941e32d96f0bb1b94751ceaee82a34cb50b93f035c815dd304131f0a3</citedby><cites>FETCH-LOGICAL-c417t-1abe4467941e32d96f0bb1b94751ceaee82a34cb50b93f035c815dd304131f0a3</cites><orcidid>0000-0003-3726-7799 ; 0000-0003-1275-7273 ; 0000-0002-9521-8285 ; 0000-0001-9835-1009</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29967912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ejlersen, Maria</creatorcontrib><creatorcontrib>Lou, Chenguang</creatorcontrib><creatorcontrib>Sanghvi, Yogesh S</creatorcontrib><creatorcontrib>Tor, Yitzhak</creatorcontrib><creatorcontrib>Wengel, Jesper</creatorcontrib><title>Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2'-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.</description><subject>Boronic Acids - chemistry</subject><subject>Catalysis</subject><subject>Chemical reactions</subject><subject>Coupling</subject><subject>Cross coupling</subject><subject>Idoxuridine - analogs & derivatives</subject><subject>Idoxuridine - chemistry</subject><subject>Oligodeoxyribonucleotides - chemistry</subject><subject>Oligonucleotides</subject><subject>Palladium - chemistry</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF9LwzAUxYMobk5f_ABS8EWEatIkbfIoZTphIvgHfCtJms7MtplNA85Pb7pNH7wv53L5cTj3AHCK4BWCmF8rphREOIXve2AclMSUsLf9Yac8zjChI3Dk3BKGQZQdglHCeZpxlIzB04MtTWWU6I1tI1tFtjYLW2r7tW69qrXtTaldJNeRbWNla9-00bP_9h8mUp11Ltz8qjbtIuq0UIOJOwYHlaidPtnpBLzeTl_yWTx_vLvPb-axIijrYySkJiTEIEjjpORpBaVEkpOMIqWF1iwRmChJoeS4gpgqhmhZYkgQRhUUeAIutr6rzn567fqiMU7puhattt4VCUxxhiDjNKDn_9Cl9V0b0g0UIxmkKQnU5ZbafNbpqlh1phHdukCwGJoucpbnm6ZnAT7bWXrZ6PIP_a0W_wCrIHk1</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Ejlersen, Maria</creator><creator>Lou, Chenguang</creator><creator>Sanghvi, Yogesh S</creator><creator>Tor, Yitzhak</creator><creator>Wengel, Jesper</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3726-7799</orcidid><orcidid>https://orcid.org/0000-0003-1275-7273</orcidid><orcidid>https://orcid.org/0000-0002-9521-8285</orcidid><orcidid>https://orcid.org/0000-0001-9835-1009</orcidid></search><sort><creationdate>2018</creationdate><title>Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions</title><author>Ejlersen, Maria ; Lou, Chenguang ; Sanghvi, Yogesh S ; Tor, Yitzhak ; Wengel, Jesper</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1abe4467941e32d96f0bb1b94751ceaee82a34cb50b93f035c815dd304131f0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Boronic Acids - chemistry</topic><topic>Catalysis</topic><topic>Chemical reactions</topic><topic>Coupling</topic><topic>Cross coupling</topic><topic>Idoxuridine - analogs & derivatives</topic><topic>Idoxuridine - chemistry</topic><topic>Oligodeoxyribonucleotides - chemistry</topic><topic>Oligonucleotides</topic><topic>Palladium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ejlersen, Maria</creatorcontrib><creatorcontrib>Lou, Chenguang</creatorcontrib><creatorcontrib>Sanghvi, Yogesh S</creatorcontrib><creatorcontrib>Tor, Yitzhak</creatorcontrib><creatorcontrib>Wengel, Jesper</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ejlersen, Maria</au><au>Lou, Chenguang</au><au>Sanghvi, Yogesh S</au><au>Tor, Yitzhak</au><au>Wengel, Jesper</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2018</date><risdate>2018</risdate><volume>54</volume><issue>57</issue><spage>8003</spage><epage>8006</epage><pages>8003-8006</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2'-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29967912</pmid><doi>10.1039/c8cc01360h</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-3726-7799</orcidid><orcidid>https://orcid.org/0000-0003-1275-7273</orcidid><orcidid>https://orcid.org/0000-0002-9521-8285</orcidid><orcidid>https://orcid.org/0000-0001-9835-1009</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2018, Vol.54 (57), p.8003-8006 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2063710895 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Boronic Acids - chemistry Catalysis Chemical reactions Coupling Cross coupling Idoxuridine - analogs & derivatives Idoxuridine - chemistry Oligodeoxyribonucleotides - chemistry Oligonucleotides Palladium - chemistry |
| title | Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T08%3A52%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modification%20of%20oligodeoxynucleotides%20by%20on-column%20Suzuki%20cross-coupling%20reactions&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Ejlersen,%20Maria&rft.date=2018&rft.volume=54&rft.issue=57&rft.spage=8003&rft.epage=8006&rft.pages=8003-8006&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c8cc01360h&rft_dat=%3Cproquest_cross%3E2063710895%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2068470564&rft_id=info:pmid/29967912&rfr_iscdi=true |