HIV tat and neurotoxicity

HIV tat is the transactivator of HIV-1, supporting efficient viral replication by stabilizing the transcription of viral genes. Tat can be released from HIV-infected cells and alter several functions in uninfected cells. In the brain, tat induces neuronal dysfunction/toxicity, even though neurons ca...

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Veröffentlicht in:	Microbes and infection 2006-04, Vol.8 (5), p.1347-1357
Hauptverfasser:	King, J.E., Eugenin, E.A., Buckner, C.M., Berman, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Dementia Complex - etiology Apoptosis Biological and medical sciences Brain - pathology CCL2 Chemokine CCL2 - metabolism Encephalitis, Viral - etiology Fundamental and applied biological sciences. Psychology Gene Products, tat - toxicity Glutamate HIV Infections - complications Human immunodeficiency virus 1 Humans Inflammation Microbiology Miscellaneous NeuroAIDS Neurons - pathology tat Gene Products, Human Immunodeficiency Virus Virology
Online-Zugang:	Volltext
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