A role for endogenous reverse transcriptase in tumorigenesis and as a target in differentiating cancer therapy

An unexpected result emerging from completion of the genome sequencing project is that a large portion of mammalian genomes is constituted by retrotransposons. A large body of published data supports the conclusion that retrotransposons are biologically active elements and indicates that retrotransp...

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Veröffentlicht in:	Genes chromosomes & cancer 2006-01, Vol.45 (1), p.1-10
Hauptverfasser:	Sinibaldi-Vallebona, Paola, Lavia, Patrizia, Garaci, Enrico, Spadafora, Corrado
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Cell Differentiation - drug effects Cell Line, Tumor Cell Transformation, Neoplastic Gene Silencing - drug effects Genetic Therapy Humans Neoplasms - enzymology Neoplasms - pathology Neoplasms - therapy Retroelements Reverse Transcriptase Inhibitors - therapeutic use RNA-Directed DNA Polymerase - genetics RNA-Directed DNA Polymerase - physiology
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