The effect of cantharidins on leukemic stem cells

To identify an agent with specific activity against leukemic stem cells (LSCs), we evaluated compounds that targeted hepatic leukemia factor (HLF), a gene implicated in hematopoietic stem cell (HSCs) regulation, that we found overexpressed in LSCs. Cantharidin, a natural toxin from blister beetles,...

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Veröffentlicht in:	International journal of cancer 2009-05, Vol.124 (9), p.2186-2199
Hauptverfasser:	Dorn, David C., Kou, Cynthia A., Png, Kim J., Moore, Malcolm A.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AML xenograft model Animals Antibiotics, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - pharmacology Apoptosis - drug effects Arylamine N-Acetyltransferase - antagonists & inhibitors Basic-Leucine Zipper Transcription Factors - metabolism Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cantharidin - pharmacology cantharidin norcantharidin Caspases - metabolism Cell Cycle - drug effects Colony-Forming Units Assay Cytarabine - pharmacology Daunorubicin - pharmacology Enzyme Inhibitors - pharmacology Female Fetal Blood - cytology Fetal Blood - drug effects Fetal Blood - metabolism Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis leukemic stem cells LSC in vitro model Luminescence Medical sciences Mice Mice, Inbred NOD Mice, SCID Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phosphorylation - drug effects Proto-Oncogene Proteins c-myc - metabolism Snail Family Transcription Factors STAT5 Transcription Factor - metabolism Stromal Cells - drug effects Stromal Cells - metabolism Survival Rate Transcription Factors - metabolism Transplantation, Heterologous Tumor Suppressor Protein p53 - metabolism Tumors
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