Evaluation of Antinociceptive and Anti-inflammatory Activity of Phytosterol Present in Chloroform Extract of Phyllanthus Maderaspatensis
Inflammation and pain is a common cause of medical consultation which generally occurs when a tissue is injured. In recent scenario, attention has been paid for screening new drugs with analgesic activity from plant sources, to reduce or treat pain with less adverse effects than allopathic drugs. Th...
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| Veröffentlicht in: | Indian journal of physiology and pharmacology 2016-01, Vol.60 (1), p.90-95 |
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| container_title | Indian journal of physiology and pharmacology |
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| creator | Wagle, Nabin Nagarjuna, S Sharma, Hemraj Dangi, Nim Bahadur Sapkota, Hari Prasad Naik, B Shreedhar Padhaya, Ramesh Raj |
| description | Inflammation and pain is a common cause of medical consultation which generally occurs when a tissue is
injured. In recent scenario, attention has been paid for screening new drugs with analgesic activity from plant
sources, to reduce or treat pain with less adverse effects than allopathic drugs. The objectives of this
research work was to evaluate the antinociceptive and anti-inflammatory activity of phytosterol present in
chloroform extract of Phyllanthus maderaspatensis (CEPM) through carrageenan-induced hind paw oedema
and hot plate method in male wistar rats. The test groups received CEPM (suspended in 1%
caboxymethylcellulose, CMC) at doses 400 mg/kg, p.o.; the reference group received indomethacin (10 mg/
kg, in 1% CMC, p.o.) as positive control and the negative control animals received the vehicle only (1%
CMC, 10 mL/kg, p.o.). Oral administration of CEPM or indomethacin showed significant (P |
| format | Article |
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injured. In recent scenario, attention has been paid for screening new drugs with analgesic activity from plant
sources, to reduce or treat pain with less adverse effects than allopathic drugs. The objectives of this
research work was to evaluate the antinociceptive and anti-inflammatory activity of phytosterol present in
chloroform extract of Phyllanthus maderaspatensis (CEPM) through carrageenan-induced hind paw oedema
and hot plate method in male wistar rats. The test groups received CEPM (suspended in 1%
caboxymethylcellulose, CMC) at doses 400 mg/kg, p.o.; the reference group received indomethacin (10 mg/
kg, in 1% CMC, p.o.) as positive control and the negative control animals received the vehicle only (1%
CMC, 10 mL/kg, p.o.). Oral administration of CEPM or indomethacin showed significant (P<0.001) effect in
the reduction of the paw oedema induced by 0.1 mL of 1% carrageenan (in 1% CMC) solution into the subplantar
region. CEPM showed the highest inhibition 71.42% at 3rd hr. CEPM extract and pentazocin
significantly (P<0.001) increases the basal reaction time when compare to control group. The present study
demonstrates the potential anti-inflammatory and analgesic effect of the CEPM which supports the claims by the traditional medicine practitioners.</description><identifier>ISSN: 0019-5499</identifier><identifier>PMID: 29956900</identifier><language>eng</language><publisher>India</publisher><ispartof>Indian journal of physiology and pharmacology, 2016-01, Vol.60 (1), p.90-95</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29956900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagle, Nabin</creatorcontrib><creatorcontrib>Nagarjuna, S</creatorcontrib><creatorcontrib>Sharma, Hemraj</creatorcontrib><creatorcontrib>Dangi, Nim Bahadur</creatorcontrib><creatorcontrib>Sapkota, Hari Prasad</creatorcontrib><creatorcontrib>Naik, B Shreedhar</creatorcontrib><creatorcontrib>Padhaya, Ramesh Raj</creatorcontrib><title>Evaluation of Antinociceptive and Anti-inflammatory Activity of Phytosterol Present in Chloroform Extract of Phyllanthus Maderaspatensis</title><title>Indian journal of physiology and pharmacology</title><addtitle>Indian J Physiol Pharmacol</addtitle><description>Inflammation and pain is a common cause of medical consultation which generally occurs when a tissue is
injured. In recent scenario, attention has been paid for screening new drugs with analgesic activity from plant
sources, to reduce or treat pain with less adverse effects than allopathic drugs. The objectives of this
research work was to evaluate the antinociceptive and anti-inflammatory activity of phytosterol present in
chloroform extract of Phyllanthus maderaspatensis (CEPM) through carrageenan-induced hind paw oedema
and hot plate method in male wistar rats. The test groups received CEPM (suspended in 1%
caboxymethylcellulose, CMC) at doses 400 mg/kg, p.o.; the reference group received indomethacin (10 mg/
kg, in 1% CMC, p.o.) as positive control and the negative control animals received the vehicle only (1%
CMC, 10 mL/kg, p.o.). Oral administration of CEPM or indomethacin showed significant (P<0.001) effect in
the reduction of the paw oedema induced by 0.1 mL of 1% carrageenan (in 1% CMC) solution into the subplantar
region. CEPM showed the highest inhibition 71.42% at 3rd hr. CEPM extract and pentazocin
significantly (P<0.001) increases the basal reaction time when compare to control group. The present study
demonstrates the potential anti-inflammatory and analgesic effect of the CEPM which supports the claims by the traditional medicine practitioners.</description><issn>0019-5499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNo1kE1OwzAQhb0A0VK4AvKSTSTHdlJ7WVXlRyqiC1hHTjxRjBw72E5FbsCxSaGs5mneN6OZd4GWhOQyK7iUC3Qd4wchhRBMXqEFlbIoJSFL9L07KjuqZLzDvsUbl4zzjWlgSOYIWDn928uMa63qe5V8mPCmmU2TptPEoZuSjwmCt_gQIIJL2Di87awPvvWhx7uvFFSTzrC1yqVujPhFaQgqDiqBiybeoMtW2Qi357pC7w-7t-1Ttn99fN5u9tmQ0zJlmilREC6hbiQwKlrGGRDBai3qNtc15_NnjOezppSsa8YFF-u11iAFl6xgK3T_t3cI_nOEmKrexAZOZ4EfY0VJSQUrSS5m9O6MjnUPuhqC6VWYqv_02A-f321_</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Wagle, Nabin</creator><creator>Nagarjuna, S</creator><creator>Sharma, Hemraj</creator><creator>Dangi, Nim Bahadur</creator><creator>Sapkota, Hari Prasad</creator><creator>Naik, B Shreedhar</creator><creator>Padhaya, Ramesh Raj</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Evaluation of Antinociceptive and Anti-inflammatory Activity of Phytosterol Present in Chloroform Extract of Phyllanthus Maderaspatensis</title><author>Wagle, Nabin ; Nagarjuna, S ; Sharma, Hemraj ; Dangi, Nim Bahadur ; Sapkota, Hari Prasad ; Naik, B Shreedhar ; Padhaya, Ramesh Raj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-d3a85049ebc9e328f343e083bd8bf1db44956341f1d2207b3484877dde9849353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Wagle, Nabin</creatorcontrib><creatorcontrib>Nagarjuna, S</creatorcontrib><creatorcontrib>Sharma, Hemraj</creatorcontrib><creatorcontrib>Dangi, Nim Bahadur</creatorcontrib><creatorcontrib>Sapkota, Hari Prasad</creatorcontrib><creatorcontrib>Naik, B Shreedhar</creatorcontrib><creatorcontrib>Padhaya, Ramesh Raj</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of physiology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagle, Nabin</au><au>Nagarjuna, S</au><au>Sharma, Hemraj</au><au>Dangi, Nim Bahadur</au><au>Sapkota, Hari Prasad</au><au>Naik, B Shreedhar</au><au>Padhaya, Ramesh Raj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Antinociceptive and Anti-inflammatory Activity of Phytosterol Present in Chloroform Extract of Phyllanthus Maderaspatensis</atitle><jtitle>Indian journal of physiology and pharmacology</jtitle><addtitle>Indian J Physiol Pharmacol</addtitle><date>2016-01</date><risdate>2016</risdate><volume>60</volume><issue>1</issue><spage>90</spage><epage>95</epage><pages>90-95</pages><issn>0019-5499</issn><abstract>Inflammation and pain is a common cause of medical consultation which generally occurs when a tissue is
injured. In recent scenario, attention has been paid for screening new drugs with analgesic activity from plant
sources, to reduce or treat pain with less adverse effects than allopathic drugs. The objectives of this
research work was to evaluate the antinociceptive and anti-inflammatory activity of phytosterol present in
chloroform extract of Phyllanthus maderaspatensis (CEPM) through carrageenan-induced hind paw oedema
and hot plate method in male wistar rats. The test groups received CEPM (suspended in 1%
caboxymethylcellulose, CMC) at doses 400 mg/kg, p.o.; the reference group received indomethacin (10 mg/
kg, in 1% CMC, p.o.) as positive control and the negative control animals received the vehicle only (1%
CMC, 10 mL/kg, p.o.). Oral administration of CEPM or indomethacin showed significant (P<0.001) effect in
the reduction of the paw oedema induced by 0.1 mL of 1% carrageenan (in 1% CMC) solution into the subplantar
region. CEPM showed the highest inhibition 71.42% at 3rd hr. CEPM extract and pentazocin
significantly (P<0.001) increases the basal reaction time when compare to control group. The present study
demonstrates the potential anti-inflammatory and analgesic effect of the CEPM which supports the claims by the traditional medicine practitioners.</abstract><cop>India</cop><pmid>29956900</pmid><tpages>6</tpages></addata></record> |
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| title | Evaluation of Antinociceptive and Anti-inflammatory Activity of Phytosterol Present in Chloroform Extract of Phyllanthus Maderaspatensis |
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