Prevalence and Characteristics of Sequence Type 131 Escherichia coli Isolated from Children with Bacteremia in 2000–2015

Escherichia coli sequence type (ST) 131 has emerged as a higher virulent and multidrug-resistant pathogen worldwide. This study aimed to identify the prevalence and characteristics of E. coli ST131 isolated from Korean children with bacteremia at a single center for 16 years. We retrospectively revi...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2018-12, Vol.24 (10), p.1552-1558
Hauptverfasser:	Park, Ji Young, Yun, Ki Wook, Choi, Eun Hwa, Lee, Hoan Jong
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Sprache:	eng
Schlagworte:	Adhesins, Escherichia coli - genetics Adolescent Adults Amikacin Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacteremia Bacteremia - epidemiology Bacteremia - microbiology Bacteria beta-Lactamases - genetics Cefotaxime Child Child, Preschool Children Children & youth Cloning Deoxyribonucleic acid DNA Drug resistance Drug Resistance, Bacterial - genetics E coli Empirical analysis Epidemiology Escherichia coli Escherichia coli - genetics Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Escherichia coli Proteins - genetics Female Fimbriae Proteins - genetics Genes Gentamicin Hospitals Humans Infant M gene Male Microbial Sensitivity Tests Multidrug resistance Multilocus Sequence Typing Patients Pediatrics Piperacillin Prevalence Republic of Korea - epidemiology Retrospective Studies Sepsis Sepsis - microbiology Studies Tazobactam Urinary tract
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container_title	Microbial drug resistance (Larchmont, N.Y.)
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creator	Park, Ji Young Yun, Ki Wook Choi, Eun Hwa Lee, Hoan Jong
description	Escherichia coli sequence type (ST) 131 has emerged as a higher virulent and multidrug-resistant pathogen worldwide. This study aimed to identify the prevalence and characteristics of E. coli ST131 isolated from Korean children with bacteremia at a single center for 16 years. We retrospectively reviewed culture-proven E. coli bacteremia cases of children aged ≤18 years between 2000 and 2015. E. coli isolates were analyzed using multilocus sequence typing, fimH typing, and CTX-M typing. Among 177 children with E. coli bacteremia, a total of 21 (11.9%) ST131 isolates and 37 (20.9%) extended spectrum β-lactamase (ESBL)-producing E. coli were identified. Nineteen (90.5%) isolates of ST131 E. coli had the fimH gene, of which three were assigned to subclone H30. There was a significant difference in prevalence of ESBL production between ST131 ( n = 8, 38.1%) and non-ST131 ( n = 29, 18.6%) isolates ( p = 0.039). Five ESBL-producing ST131 E. coli isolates had the bla CTX-M gene: two carried bla CTX-M-14 , two carried bla CTX-M-15 , and one carried both bla CTX-M-14 and bla CTX-M-15 . ST131 isolates had higher resistance rates to piperacillin/tazobactam (38.5% vs. 10.0%), cefotaxime (38.1% vs. 16.7%), amikacin (23.8% vs. 1.9%), and gentamicin (52.4% vs. 28.8%) than non-ST131 isolates ( p
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This study aimed to identify the prevalence and characteristics of E. coli ST131 isolated from Korean children with bacteremia at a single center for 16 years. We retrospectively reviewed culture-proven E. coli bacteremia cases of children aged ≤18 years between 2000 and 2015. E. coli isolates were analyzed using multilocus sequence typing, fimH typing, and CTX-M typing. Among 177 children with E. coli bacteremia, a total of 21 (11.9%) ST131 isolates and 37 (20.9%) extended spectrum β-lactamase (ESBL)-producing E. coli were identified. Nineteen (90.5%) isolates of ST131 E. coli had the fimH gene, of which three were assigned to subclone H30. There was a significant difference in prevalence of ESBL production between ST131 ( n = 8, 38.1%) and non-ST131 ( n = 29, 18.6%) isolates ( p = 0.039). Five ESBL-producing ST131 E. coli isolates had the bla CTX-M gene: two carried bla CTX-M-14 , two carried bla CTX-M-15 , and one carried both bla CTX-M-14 and bla CTX-M-15 . ST131 isolates had higher resistance rates to piperacillin/tazobactam (38.5% vs. 10.0%), cefotaxime (38.1% vs. 16.7%), amikacin (23.8% vs. 1.9%), and gentamicin (52.4% vs. 28.8%) than non-ST131 isolates ( p < 0.05, for all). There were no significant differences in the rate of shock and mortality between patients infected with ST131 (16.7% and 5.6%) and non-ST131 isolates (24.2% and 9.8%). Prevalence of ST131 E. coli causing bacteremia in children was not different from that in adults or that causing urinary tract infection in children in Korea. However, because ST131 clones are more likely to be ESBL producing and more resistant to empirical antibiotics used in sepsis than are non-ST131 clones, surveillance for the prevalence of ST131 and its drug resistance should be continued.</description><identifier>ISSN: 1076-6294</identifier><identifier>EISSN: 1931-8448</identifier><identifier>DOI: 10.1089/mdr.2017.0224</identifier><identifier>PMID: 29957128</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Adhesins, Escherichia coli - genetics ; Adolescent ; Adults ; Amikacin ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Bacteremia ; Bacteremia - epidemiology ; Bacteremia - microbiology ; Bacteria ; beta-Lactamases - genetics ; Cefotaxime ; Child ; Child, Preschool ; Children ; Children & youth ; Cloning ; Deoxyribonucleic acid ; DNA ; Drug resistance ; Drug Resistance, Bacterial - genetics ; E coli ; Empirical analysis ; Epidemiology ; Escherichia coli ; Escherichia coli - genetics ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Escherichia coli Proteins - genetics ; Female ; Fimbriae Proteins - genetics ; Genes ; Gentamicin ; Hospitals ; Humans ; Infant ; M gene ; Male ; Microbial Sensitivity Tests ; Multidrug resistance ; Multilocus Sequence Typing ; Patients ; Pediatrics ; Piperacillin ; Prevalence ; Republic of Korea - epidemiology ; Retrospective Studies ; Sepsis ; Sepsis - microbiology ; Studies ; Tazobactam ; Urinary tract</subject><ispartof>Microbial drug resistance (Larchmont, N.Y.), 2018-12, Vol.24 (10), p.1552-1558</ispartof><rights>2018, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright 2018, Mary Ann Liebert, Inc., publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-d229b9967b0e0e87618d9482e80be4157b145a222cfd84b19fb2c20ea982603c3</citedby><cites>FETCH-LOGICAL-c365t-d229b9967b0e0e87618d9482e80be4157b145a222cfd84b19fb2c20ea982603c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29957128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Ji Young</creatorcontrib><creatorcontrib>Yun, Ki Wook</creatorcontrib><creatorcontrib>Choi, Eun Hwa</creatorcontrib><creatorcontrib>Lee, Hoan Jong</creatorcontrib><title>Prevalence and Characteristics of Sequence Type 131 Escherichia coli Isolated from Children with Bacteremia in 2000–2015</title><title>Microbial drug resistance (Larchmont, N.Y.)</title><addtitle>Microb Drug Resist</addtitle><description>Escherichia coli sequence type (ST) 131 has emerged as a higher virulent and multidrug-resistant pathogen worldwide. This study aimed to identify the prevalence and characteristics of E. coli ST131 isolated from Korean children with bacteremia at a single center for 16 years. We retrospectively reviewed culture-proven E. coli bacteremia cases of children aged ≤18 years between 2000 and 2015. E. coli isolates were analyzed using multilocus sequence typing, fimH typing, and CTX-M typing. Among 177 children with E. coli bacteremia, a total of 21 (11.9%) ST131 isolates and 37 (20.9%) extended spectrum β-lactamase (ESBL)-producing E. coli were identified. Nineteen (90.5%) isolates of ST131 E. coli had the fimH gene, of which three were assigned to subclone H30. There was a significant difference in prevalence of ESBL production between ST131 ( n = 8, 38.1%) and non-ST131 ( n = 29, 18.6%) isolates ( p = 0.039). Five ESBL-producing ST131 E. coli isolates had the bla CTX-M gene: two carried bla CTX-M-14 , two carried bla CTX-M-15 , and one carried both bla CTX-M-14 and bla CTX-M-15 . ST131 isolates had higher resistance rates to piperacillin/tazobactam (38.5% vs. 10.0%), cefotaxime (38.1% vs. 16.7%), amikacin (23.8% vs. 1.9%), and gentamicin (52.4% vs. 28.8%) than non-ST131 isolates ( p < 0.05, for all). There were no significant differences in the rate of shock and mortality between patients infected with ST131 (16.7% and 5.6%) and non-ST131 isolates (24.2% and 9.8%). Prevalence of ST131 E. coli causing bacteremia in children was not different from that in adults or that causing urinary tract infection in children in Korea. However, because ST131 clones are more likely to be ESBL producing and more resistant to empirical antibiotics used in sepsis than are non-ST131 clones, surveillance for the prevalence of ST131 and its drug resistance should be continued.</description><subject>Adhesins, Escherichia coli - genetics</subject><subject>Adolescent</subject><subject>Adults</subject><subject>Amikacin</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacteremia</subject><subject>Bacteremia - epidemiology</subject><subject>Bacteremia - microbiology</subject><subject>Bacteria</subject><subject>beta-Lactamases - genetics</subject><subject>Cefotaxime</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cloning</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>E coli</subject><subject>Empirical analysis</subject><subject>Epidemiology</subject><subject>Escherichia coli</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli Infections - epidemiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Female</subject><subject>Fimbriae Proteins - genetics</subject><subject>Genes</subject><subject>Gentamicin</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>M gene</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Multidrug resistance</subject><subject>Multilocus Sequence Typing</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Piperacillin</subject><subject>Prevalence</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Sepsis</subject><subject>Sepsis - microbiology</subject><subject>Studies</subject><subject>Tazobactam</subject><subject>Urinary tract</subject><issn>1076-6294</issn><issn>1931-8448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkbtOHDEUhi0ECmRJSYsspUkzi33smbFLstoEpJUSKVBbHs8ZrdFcFnsWtFR5h7xhniTeCxRpqGzZn_7zH32EXHA25Uzpq64OU2C8nDIAeUTOuBY8U1Kq43RnZZEVoOUp-RjjA2Ms54X4QE5B67zkoM7Iy8-AT7bF3iG1fU1nSxusGzH4OHoX6dDQX_i43v3fbVZIueB0Ht0yEW7pLXVD6-ltHFo7Yk2bMHQpw7d1wJ4--3FJv-7isEus7ymkEn9__0mN83Ny0tg24qfDOSH33-Z3s5ts8eP77ex6kTlR5GNWA-hK66KsGDJUZcFVraUCVKxCyfOy4jK3AOCaWsmK66YCBwytVlAw4cSEfNnnrsKQNomj6Xx02La2x2EdDbAClJBpTEI__4c-DOvQp3YGeC5FWTIpE5XtKReGGAM2ZhV8Z8PGcGa2UkySYrZSzFZK4i8Pqeuqw_qNfrWQALEHts-271uPFYbxndh_d2qXWQ</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Park, Ji Young</creator><creator>Yun, Ki Wook</creator><creator>Choi, Eun Hwa</creator><creator>Lee, Hoan Jong</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Prevalence and Characteristics of Sequence Type 131 Escherichia coli Isolated from Children with Bacteremia in 2000–2015</title><author>Park, Ji Young ; Yun, Ki Wook ; Choi, Eun Hwa ; Lee, Hoan Jong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-d229b9967b0e0e87618d9482e80be4157b145a222cfd84b19fb2c20ea982603c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adhesins, Escherichia coli - genetics</topic><topic>Adolescent</topic><topic>Adults</topic><topic>Amikacin</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Bacteremia</topic><topic>Bacteremia - epidemiology</topic><topic>Bacteremia - microbiology</topic><topic>Bacteria</topic><topic>beta-Lactamases - genetics</topic><topic>Cefotaxime</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cloning</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>E coli</topic><topic>Empirical analysis</topic><topic>Epidemiology</topic><topic>Escherichia coli</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli Infections - epidemiology</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Female</topic><topic>Fimbriae Proteins - genetics</topic><topic>Genes</topic><topic>Gentamicin</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>M gene</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Multidrug resistance</topic><topic>Multilocus Sequence Typing</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Piperacillin</topic><topic>Prevalence</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Sepsis</topic><topic>Sepsis - microbiology</topic><topic>Studies</topic><topic>Tazobactam</topic><topic>Urinary tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ji Young</creatorcontrib><creatorcontrib>Yun, Ki Wook</creatorcontrib><creatorcontrib>Choi, Eun Hwa</creatorcontrib><creatorcontrib>Lee, Hoan Jong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial drug resistance (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ji Young</au><au>Yun, Ki Wook</au><au>Choi, Eun Hwa</au><au>Lee, Hoan Jong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Characteristics of Sequence Type 131 Escherichia coli Isolated from Children with Bacteremia in 2000–2015</atitle><jtitle>Microbial drug resistance (Larchmont, N.Y.)</jtitle><addtitle>Microb Drug Resist</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>24</volume><issue>10</issue><spage>1552</spage><epage>1558</epage><pages>1552-1558</pages><issn>1076-6294</issn><eissn>1931-8448</eissn><abstract>Escherichia coli sequence type (ST) 131 has emerged as a higher virulent and multidrug-resistant pathogen worldwide. This study aimed to identify the prevalence and characteristics of E. coli ST131 isolated from Korean children with bacteremia at a single center for 16 years. We retrospectively reviewed culture-proven E. coli bacteremia cases of children aged ≤18 years between 2000 and 2015. E. coli isolates were analyzed using multilocus sequence typing, fimH typing, and CTX-M typing. Among 177 children with E. coli bacteremia, a total of 21 (11.9%) ST131 isolates and 37 (20.9%) extended spectrum β-lactamase (ESBL)-producing E. coli were identified. Nineteen (90.5%) isolates of ST131 E. coli had the fimH gene, of which three were assigned to subclone H30. There was a significant difference in prevalence of ESBL production between ST131 ( n = 8, 38.1%) and non-ST131 ( n = 29, 18.6%) isolates ( p = 0.039). Five ESBL-producing ST131 E. coli isolates had the bla CTX-M gene: two carried bla CTX-M-14 , two carried bla CTX-M-15 , and one carried both bla CTX-M-14 and bla CTX-M-15 . ST131 isolates had higher resistance rates to piperacillin/tazobactam (38.5% vs. 10.0%), cefotaxime (38.1% vs. 16.7%), amikacin (23.8% vs. 1.9%), and gentamicin (52.4% vs. 28.8%) than non-ST131 isolates ( p < 0.05, for all). There were no significant differences in the rate of shock and mortality between patients infected with ST131 (16.7% and 5.6%) and non-ST131 isolates (24.2% and 9.8%). Prevalence of ST131 E. coli causing bacteremia in children was not different from that in adults or that causing urinary tract infection in children in Korea. However, because ST131 clones are more likely to be ESBL producing and more resistant to empirical antibiotics used in sepsis than are non-ST131 clones, surveillance for the prevalence of ST131 and its drug resistance should be continued.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>29957128</pmid><doi>10.1089/mdr.2017.0224</doi><tpages>7</tpages></addata></record>
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subjects	Adhesins, Escherichia coli - genetics Adolescent Adults Amikacin Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacteremia Bacteremia - epidemiology Bacteremia - microbiology Bacteria beta-Lactamases - genetics Cefotaxime Child Child, Preschool Children Children & youth Cloning Deoxyribonucleic acid DNA Drug resistance Drug Resistance, Bacterial - genetics E coli Empirical analysis Epidemiology Escherichia coli Escherichia coli - genetics Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Escherichia coli Proteins - genetics Female Fimbriae Proteins - genetics Genes Gentamicin Hospitals Humans Infant M gene Male Microbial Sensitivity Tests Multidrug resistance Multilocus Sequence Typing Patients Pediatrics Piperacillin Prevalence Republic of Korea - epidemiology Retrospective Studies Sepsis Sepsis - microbiology Studies Tazobactam Urinary tract
title	Prevalence and Characteristics of Sequence Type 131 Escherichia coli Isolated from Children with Bacteremia in 2000–2015
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