HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression
Recently, increasing studies showed that long noncoding RNAs (lncRNAs) play critical roles in tumor progression. However, the function and underlying mechanism of HOMEOBOX A11 antisense RNA (HOXA11‐AS) on renal cancer remain unclear. In the current study, our data showed that the expression of HOXA1...
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| Veröffentlicht in: | Journal of cellular physiology 2018-12, Vol.233 (12), p.9611-9619 |
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| creator | Yang, Feng‐Qiang Zhang, Jian‐Qiu Jin, Jiang‐Jiang Yang, Chong‐Yi Zhang, Wei‐Jie Zhang, Hai‐Ming Zheng, Jun‐Hua Weng, Ze‐Ming |
| description | Recently, increasing studies showed that long noncoding RNAs (lncRNAs) play critical roles in tumor progression. However, the function and underlying mechanism of HOMEOBOX A11 antisense RNA (HOXA11‐AS) on renal cancer remain unclear. In the current study, our data showed that the expression of HOXA11‐AS was significantly upregulated in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. High HOXA11‐AS expression was associated with the advanced clinical stage, tumor stage, and lymph node metastasis. Function assays showed that HOXA11‐AS inhibition significantly suppressed renal cancer cells growth, invasion, and ETM phenotype. In addition, underlying mechanism revealed that HOXA11‐AS could act as a competing endogenous RNA (ceRNA) that repressed miR‐146b‐5p expression, which regulated its downstream target MMP16 in renal cancer. Taken together, our findings suggested that HOXA11‐AS could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis. Thus, our findings suggested that HOXA11‐AS could serve as potential therapeutic target for the treatment of renal cancer.
HOMEOBOX A11 antisense RNA could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis |
| doi_str_mv | 10.1002/jcp.26864 |
| format | Article |
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HOMEOBOX A11 antisense RNA could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.26864</identifier><identifier>PMID: 29953617</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Antisense RNA ; Cancer ; ceRNA ; Clear cell-type renal cell carcinoma ; Gene expression ; Homeobox ; HOXA11‐AS ; Kidney cancer ; Lymph nodes ; Metastases ; miR‐146b‐5p ; MMP16 ; Phenotypes ; renal cancer ; Ribonucleic acid ; RNA ; Therapeutic applications ; Tumor cell lines ; Tumors</subject><ispartof>Journal of cellular physiology, 2018-12, Vol.233 (12), p.9611-9619</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-b59da7e064569de68b05b7dfce6d09fadc26506d8b8b536ff77ad9800e8691903</citedby><cites>FETCH-LOGICAL-c3534-b59da7e064569de68b05b7dfce6d09fadc26506d8b8b536ff77ad9800e8691903</cites><orcidid>0000-0002-0650-5208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.26864$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.26864$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29953617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Feng‐Qiang</creatorcontrib><creatorcontrib>Zhang, Jian‐Qiu</creatorcontrib><creatorcontrib>Jin, Jiang‐Jiang</creatorcontrib><creatorcontrib>Yang, Chong‐Yi</creatorcontrib><creatorcontrib>Zhang, Wei‐Jie</creatorcontrib><creatorcontrib>Zhang, Hai‐Ming</creatorcontrib><creatorcontrib>Zheng, Jun‐Hua</creatorcontrib><creatorcontrib>Weng, Ze‐Ming</creatorcontrib><title>HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Recently, increasing studies showed that long noncoding RNAs (lncRNAs) play critical roles in tumor progression. However, the function and underlying mechanism of HOMEOBOX A11 antisense RNA (HOXA11‐AS) on renal cancer remain unclear. In the current study, our data showed that the expression of HOXA11‐AS was significantly upregulated in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. High HOXA11‐AS expression was associated with the advanced clinical stage, tumor stage, and lymph node metastasis. Function assays showed that HOXA11‐AS inhibition significantly suppressed renal cancer cells growth, invasion, and ETM phenotype. In addition, underlying mechanism revealed that HOXA11‐AS could act as a competing endogenous RNA (ceRNA) that repressed miR‐146b‐5p expression, which regulated its downstream target MMP16 in renal cancer. Taken together, our findings suggested that HOXA11‐AS could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis. Thus, our findings suggested that HOXA11‐AS could serve as potential therapeutic target for the treatment of renal cancer.
HOMEOBOX A11 antisense RNA could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis</description><subject>Antisense RNA</subject><subject>Cancer</subject><subject>ceRNA</subject><subject>Clear cell-type renal cell carcinoma</subject><subject>Gene expression</subject><subject>Homeobox</subject><subject>HOXA11‐AS</subject><subject>Kidney cancer</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>miR‐146b‐5p</subject><subject>MMP16</subject><subject>Phenotypes</subject><subject>renal cancer</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Therapeutic applications</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQhy0EokvhwAsgS1zoIe3YsR37uFpBS9WqFX8kbpETT7ZZJXGwE5a98Qg8I0-C2y09IPU00synT_rNj5DXDI4ZAD_Z1OMxV1qJJ2TBwBSZUJI_JYt0Y5mRgh2QFzFuAMCYPH9ODrgxMlesWJDt2dW3JWN_fv1efqZj8L2fMNLpBuk6-O10Q-3gaDv8sLH1A_UNDTjYjtZ2qDHQakfj6Id1O6xp335KFiZUlYYc6eTpPAZcz52dkF5eXjNF8WfaxFvVS_KssV3EV_fzkHz98P7L6iy7uDr9uFpeZHUuc5FV0jhbICghlXGodAWyKlxTo3JgGutqriQopytdpURNUxTWGQ2AWhlmID8k7_belO37jHEq-zbW2HV2QD_HkoPiOucCWELf_odu_BxS2kQxpkWuJReJOtpTdfAxBmzKMbS9DbuSQXnbRpnaKO_aSOybe-Nc9egeyH_vT8DJHti2He4eN5Xnq-u98i_9jpUF</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Yang, Feng‐Qiang</creator><creator>Zhang, Jian‐Qiu</creator><creator>Jin, Jiang‐Jiang</creator><creator>Yang, Chong‐Yi</creator><creator>Zhang, Wei‐Jie</creator><creator>Zhang, Hai‐Ming</creator><creator>Zheng, Jun‐Hua</creator><creator>Weng, Ze‐Ming</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0650-5208</orcidid></search><sort><creationdate>201812</creationdate><title>HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression</title><author>Yang, Feng‐Qiang ; Zhang, Jian‐Qiu ; Jin, Jiang‐Jiang ; Yang, Chong‐Yi ; Zhang, Wei‐Jie ; Zhang, Hai‐Ming ; Zheng, Jun‐Hua ; Weng, Ze‐Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-b59da7e064569de68b05b7dfce6d09fadc26506d8b8b536ff77ad9800e8691903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antisense RNA</topic><topic>Cancer</topic><topic>ceRNA</topic><topic>Clear cell-type renal cell carcinoma</topic><topic>Gene expression</topic><topic>Homeobox</topic><topic>HOXA11‐AS</topic><topic>Kidney cancer</topic><topic>Lymph nodes</topic><topic>Metastases</topic><topic>miR‐146b‐5p</topic><topic>MMP16</topic><topic>Phenotypes</topic><topic>renal cancer</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Therapeutic applications</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Feng‐Qiang</creatorcontrib><creatorcontrib>Zhang, Jian‐Qiu</creatorcontrib><creatorcontrib>Jin, Jiang‐Jiang</creatorcontrib><creatorcontrib>Yang, Chong‐Yi</creatorcontrib><creatorcontrib>Zhang, Wei‐Jie</creatorcontrib><creatorcontrib>Zhang, Hai‐Ming</creatorcontrib><creatorcontrib>Zheng, Jun‐Hua</creatorcontrib><creatorcontrib>Weng, Ze‐Ming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Feng‐Qiang</au><au>Zhang, Jian‐Qiu</au><au>Jin, Jiang‐Jiang</au><au>Yang, Chong‐Yi</au><au>Zhang, Wei‐Jie</au><au>Zhang, Hai‐Ming</au><au>Zheng, Jun‐Hua</au><au>Weng, Ze‐Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>233</volume><issue>12</issue><spage>9611</spage><epage>9619</epage><pages>9611-9619</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Recently, increasing studies showed that long noncoding RNAs (lncRNAs) play critical roles in tumor progression. However, the function and underlying mechanism of HOMEOBOX A11 antisense RNA (HOXA11‐AS) on renal cancer remain unclear. In the current study, our data showed that the expression of HOXA11‐AS was significantly upregulated in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. High HOXA11‐AS expression was associated with the advanced clinical stage, tumor stage, and lymph node metastasis. Function assays showed that HOXA11‐AS inhibition significantly suppressed renal cancer cells growth, invasion, and ETM phenotype. In addition, underlying mechanism revealed that HOXA11‐AS could act as a competing endogenous RNA (ceRNA) that repressed miR‐146b‐5p expression, which regulated its downstream target MMP16 in renal cancer. Taken together, our findings suggested that HOXA11‐AS could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis. Thus, our findings suggested that HOXA11‐AS could serve as potential therapeutic target for the treatment of renal cancer.
HOMEOBOX A11 antisense RNA could promote renal cancer cells growth and invasion by modulating miR‐146b‐5p–MMP16 axis</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29953617</pmid><doi>10.1002/jcp.26864</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0650-5208</orcidid></addata></record> |
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| subjects | Antisense RNA Cancer ceRNA Clear cell-type renal cell carcinoma Gene expression Homeobox HOXA11‐AS Kidney cancer Lymph nodes Metastases miR‐146b‐5p MMP16 Phenotypes renal cancer Ribonucleic acid RNA Therapeutic applications Tumor cell lines Tumors |
| title | HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression |
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