An anti-inflammatory role for N-acetyl aspartate in stimulated human astroglial cells

Although N-acetyl-l-aspartate (NAA) has been shown to be important to myelin synthesis and osmotic regulation, the biological rationale for the high levels of NAA found in the brain remains unknown. Here, a human astroglial cell line (STTG) was treated with NAA and stimulated with ionomycin, ionomyc...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-07, Vol.319 (3), p.847-853
Hauptverfasser:	Rael, Leonard T, Thomas, Gregory W, Bar-Or, Raphael, Craun, Michael L, Bar-Or, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Anti-Inflammatory Agents - metabolism Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Astrocyte [astroglia] Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Calcium - metabolism Cell Line Cyclooxygenase Cyclooxygenase 2 Dinoprostone - metabolism Fluorescent Dyes - metabolism Humans I-kappa B Proteins - metabolism Inhibition Interleukin-1 - pharmacology Intracellular calcium Ionomycin - pharmacology Ionophores - pharmacology Isoenzymes - metabolism Membrane Proteins N-Acetyl aspartate NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-κB Prostaglandin Prostaglandin-Endoperoxide Synthases - metabolism Tetradecanoylphorbol Acetate - pharmacology Xanthenes - metabolism
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