Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

Engineered nanoparticles offer the chance to improve drug transport and delivery through biological barriers, exploiting the possibility to leave the blood circulation and traverse the endothelial vascular bed, blood–brain barrier (BBB) included, to reach their target. It is known that nanoparticles...

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Veröffentlicht in:ACS nano 2018-07, Vol.12 (7), p.7292-7300
Hauptverfasser: Cox, Alysia, Andreozzi, Patrizia, Dal Magro, Roberta, Fiordaliso, Fabio, Corbelli, Alessandro, Talamini, Laura, Chinello, Clizia, Raimondo, Francesca, Magni, Fulvio, Tringali, Maria, Krol, Silke, Jacob Silva, Paulo, Stellacci, Francesco, Masserini, Massimo, Re, Francesca
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container_end_page 7300
container_issue 7
container_start_page 7292
container_title ACS nano
container_volume 12
creator Cox, Alysia
Andreozzi, Patrizia
Dal Magro, Roberta
Fiordaliso, Fabio
Corbelli, Alessandro
Talamini, Laura
Chinello, Clizia
Raimondo, Francesca
Magni, Fulvio
Tringali, Maria
Krol, Silke
Jacob Silva, Paulo
Stellacci, Francesco
Masserini, Massimo
Re, Francesca
description Engineered nanoparticles offer the chance to improve drug transport and delivery through biological barriers, exploiting the possibility to leave the blood circulation and traverse the endothelial vascular bed, blood–brain barrier (BBB) included, to reach their target. It is known that nanoparticles gather molecules on their surface upon contact with biological fluids, forming the “protein corona”, which can affect their fate and therapeutic/diagnostic performance, yet no information on the corona’s evolution across the barrier has been gathered so far. Using a cellular model of the BBB and gold nanoparticles, we show that the composition of the corona undergoes dramatic quantitative and qualitative molecular modifications during passage from the “blood” to the “brain” side, while it is stable once beyond the BBB. Thus, we demonstrate that the nanoparticle corona dynamically and drastically evolves upon crossing the BBB and that its initial composition is not predictive of nanoparticle fate and performance once beyond the barrier at the target organ.
doi_str_mv 10.1021/acsnano.8b03500
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title Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier
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