Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification...
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| Veröffentlicht in: | Mycological research 2008-02, Vol.112 (2), p.162-169 |
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| container_title | Mycological research |
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| creator | Fox, Ellen M. Howlett, Barbara J. |
| description | Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression and mutational analyses have confirmed the role of such gene clusters in the biosynthesis of two ETPs, sirodesmin PL and gliotoxin. The creation of mutants unable to produce these ETPs has facilitated the assessment of these molecules as virulence factors in interactions between pathogenic fungi and their hosts. |
| doi_str_mv | 10.1016/j.mycres.2007.08.017 |
| format | Article |
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Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression and mutational analyses have confirmed the role of such gene clusters in the biosynthesis of two ETPs, sirodesmin PL and gliotoxin. The creation of mutants unable to produce these ETPs has facilitated the assessment of these molecules as virulence factors in interactions between pathogenic fungi and their hosts.</description><identifier>ISSN: 0953-7562</identifier><identifier>EISSN: 1469-8102</identifier><identifier>DOI: 10.1016/j.mycres.2007.08.017</identifier><identifier>PMID: 18272357</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; biochemical pathways ; biosynthesis ; epipolythiodioxopiperazines ; Evolution, Molecular ; Fungi - genetics ; Fungi - metabolism ; Fungi - pathogenicity ; Gene Expression Regulation, Fungal ; Gliotoxin ; Gliotoxin - metabolism ; Humans ; Multigene Family ; Mycoses - microbiology ; Mycoses - veterinary ; mycotoxins ; Mycotoxins - biosynthesis ; Mycotoxins - genetics ; Pathogenicity ; piperazines ; Piperazines - metabolism ; Plant Diseases - microbiology ; plant pathogenic fungi ; secondary metabolites ; sirodesmin ; Sirodesmin PL ; Toxicity ; Virulence</subject><ispartof>Mycological research, 2008-02, Vol.112 (2), p.162-169</ispartof><rights>2007 The British Mycological Society</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-f73c4e252eac156ad92cb40c533c63425ed0deab23f61237b3c4981735bde9fe3</citedby><cites>FETCH-LOGICAL-c481t-f73c4e252eac156ad92cb40c533c63425ed0deab23f61237b3c4981735bde9fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18272357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fox, Ellen M.</creatorcontrib><creatorcontrib>Howlett, Barbara J.</creatorcontrib><title>Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi</title><title>Mycological research</title><addtitle>Mycol Res</addtitle><description>Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression and mutational analyses have confirmed the role of such gene clusters in the biosynthesis of two ETPs, sirodesmin PL and gliotoxin. The creation of mutants unable to produce these ETPs has facilitated the assessment of these molecules as virulence factors in interactions between pathogenic fungi and their hosts.</description><subject>Animals</subject><subject>biochemical pathways</subject><subject>biosynthesis</subject><subject>epipolythiodioxopiperazines</subject><subject>Evolution, Molecular</subject><subject>Fungi - genetics</subject><subject>Fungi - metabolism</subject><subject>Fungi - pathogenicity</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Gliotoxin</subject><subject>Gliotoxin - metabolism</subject><subject>Humans</subject><subject>Multigene Family</subject><subject>Mycoses - microbiology</subject><subject>Mycoses - veterinary</subject><subject>mycotoxins</subject><subject>Mycotoxins - biosynthesis</subject><subject>Mycotoxins - genetics</subject><subject>Pathogenicity</subject><subject>piperazines</subject><subject>Piperazines - metabolism</subject><subject>Plant Diseases - microbiology</subject><subject>plant pathogenic fungi</subject><subject>secondary metabolites</subject><subject>sirodesmin</subject><subject>Sirodesmin PL</subject><subject>Toxicity</subject><subject>Virulence</subject><issn>0953-7562</issn><issn>1469-8102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAURUVoSCaT_IPSetWdnSfJsuxNoQn5goEsklkLWX6e0WBbU8kOnfz6KHigu6weD869XA4h3ylkFGhxvcv6g_EYMgYgMygzoPKELGheVGlJgX0jC6gET6Uo2Dm5CGEHQDml_Iyc05JJxoVckOcb68JhGLc4WpNscMDEdFMY0YekdT7Bvd277jBurWus--fii16_2wFDYoektZ3ucRjdFPFp2NhLctrqLuDV8S7J-v7u9fYxXT0_PN3-WaUmL-mYtpKbHJlgqA0VhW4qZuocjODcFDxnAhtoUNeMtwVlXNYRr0oquagbrFrkS_Jr7t1793fCMKreBoNdpweMYxSDgslKlBHMZ9B4F4LHVu297bU_KArqU6TaqVmk-hSpoFRRZIz9OPZPdY_N_9DRXAR-zkCrndIbb4Nav7BoGKCUOed5JH7PBEYPbxa9CsbiYLCxHs2oGme_3vABpkqRwg</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Fox, Ellen M.</creator><creator>Howlett, Barbara J.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope></search><sort><creationdate>20080201</creationdate><title>Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi</title><author>Fox, Ellen M. ; Howlett, Barbara J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-f73c4e252eac156ad92cb40c533c63425ed0deab23f61237b3c4981735bde9fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>biochemical pathways</topic><topic>biosynthesis</topic><topic>epipolythiodioxopiperazines</topic><topic>Evolution, Molecular</topic><topic>Fungi - genetics</topic><topic>Fungi - metabolism</topic><topic>Fungi - pathogenicity</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Gliotoxin</topic><topic>Gliotoxin - metabolism</topic><topic>Humans</topic><topic>Multigene Family</topic><topic>Mycoses - microbiology</topic><topic>Mycoses - veterinary</topic><topic>mycotoxins</topic><topic>Mycotoxins - biosynthesis</topic><topic>Mycotoxins - genetics</topic><topic>Pathogenicity</topic><topic>piperazines</topic><topic>Piperazines - metabolism</topic><topic>Plant Diseases - microbiology</topic><topic>plant pathogenic fungi</topic><topic>secondary metabolites</topic><topic>sirodesmin</topic><topic>Sirodesmin PL</topic><topic>Toxicity</topic><topic>Virulence</topic><toplevel>online_resources</toplevel><creatorcontrib>Fox, Ellen M.</creatorcontrib><creatorcontrib>Howlett, Barbara J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Mycological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fox, Ellen M.</au><au>Howlett, Barbara J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi</atitle><jtitle>Mycological research</jtitle><addtitle>Mycol Res</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>112</volume><issue>2</issue><spage>162</spage><epage>169</epage><pages>162-169</pages><issn>0953-7562</issn><eissn>1469-8102</eissn><abstract>Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. 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| fulltext | fulltext |
| identifier | ISSN: 0953-7562 |
| ispartof | Mycological research, 2008-02, Vol.112 (2), p.162-169 |
| issn | 0953-7562 1469-8102 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals biochemical pathways biosynthesis epipolythiodioxopiperazines Evolution, Molecular Fungi - genetics Fungi - metabolism Fungi - pathogenicity Gene Expression Regulation, Fungal Gliotoxin Gliotoxin - metabolism Humans Multigene Family Mycoses - microbiology Mycoses - veterinary mycotoxins Mycotoxins - biosynthesis Mycotoxins - genetics Pathogenicity piperazines Piperazines - metabolism Plant Diseases - microbiology plant pathogenic fungi secondary metabolites sirodesmin Sirodesmin PL Toxicity Virulence |
| title | Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi |
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