Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character
DNA nanotubes can template the growth of nanowires 1 , orient transmembrane proteins for nuclear magnetic resonance determination 2 , and can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers 3 . Current methods for the construction of DNA nanotubes resu...
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| Veröffentlicht in: | Nature nanotechnology 2009-06, Vol.4 (6), p.349-352 |
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| creator | Aldaye, Faisal A. Lo, Pik Kwan Karam, Pierre McLaughlin, Christopher K. Cosa, Gonzalo Sleiman, Hanadi F. |
| description | DNA nanotubes can template the growth of nanowires
1
, orient transmembrane proteins for nuclear magnetic resonance determination
2
, and can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers
3
. Current methods for the construction of DNA nanotubes result in symmetrical and cylindrical assemblies that are entirely double-stranded
2
,
4
,
5
,
6
,
7
,
8
,
9
,
10
,
11
. Here, we report a modular approach to DNA nanotube synthesis that provides access to geometrically well-defined triangular and square-shaped DNA nanotubes. We also construct the first nanotube assemblies that can exist in double- and single-stranded forms with significantly different stiffness. This approach allows for parameters such as geometry, stiffness, and single- or double-stranded character to be fine-tuned, and could enable the creation of designer nanotubes for a range of applications, including the growth of nanowires of controlled shape, the loading and release of cargo, and the real-time modulation of stiffness and persistence length within DNA interconnects.
DNA nanotubes can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers. Researchers have now reported a modular approach to DNA nanotube synthesis that can create geometrically well-defined triangular and square tubes. The method allows parameters such as geometry, stiffness and single- or double-stranded character to be tuned, and could provide access to designer nanotubes for a range of applications. |
| doi_str_mv | 10.1038/nnano.2009.72 |
| format | Article |
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1
, orient transmembrane proteins for nuclear magnetic resonance determination
2
, and can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers
3
. Current methods for the construction of DNA nanotubes result in symmetrical and cylindrical assemblies that are entirely double-stranded
2
,
4
,
5
,
6
,
7
,
8
,
9
,
10
,
11
. Here, we report a modular approach to DNA nanotube synthesis that provides access to geometrically well-defined triangular and square-shaped DNA nanotubes. We also construct the first nanotube assemblies that can exist in double- and single-stranded forms with significantly different stiffness. This approach allows for parameters such as geometry, stiffness, and single- or double-stranded character to be fine-tuned, and could enable the creation of designer nanotubes for a range of applications, including the growth of nanowires of controlled shape, the loading and release of cargo, and the real-time modulation of stiffness and persistence length within DNA interconnects.
DNA nanotubes can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers. Researchers have now reported a modular approach to DNA nanotube synthesis that can create geometrically well-defined triangular and square tubes. The method allows parameters such as geometry, stiffness and single- or double-stranded character to be tuned, and could provide access to designer nanotubes for a range of applications.</description><identifier>ISSN: 1748-3387</identifier><identifier>EISSN: 1748-3395</identifier><identifier>DOI: 10.1038/nnano.2009.72</identifier><identifier>PMID: 19498394</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Assemblies ; Chemistry and Materials Science ; Construction methods ; Current carriers ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; DNA biosynthesis ; DNA, Circular - chemistry ; DNA, Single-Stranded - chemistry ; Drug carriers ; Drug delivery ; Geometry ; Interconnections ; letter ; Materials Science ; Membrane proteins ; Microscopy, Atomic Force ; Modular construction ; Molecular motors ; Nanotechnology ; Nanotechnology - methods ; Nanotechnology and Microengineering ; Nanotubes ; Nanotubes - chemistry ; Nanowires ; NMR ; Nuclear magnetic resonance ; Parameters ; Stiffness ; Synthesis ; Tubes</subject><ispartof>Nature nanotechnology, 2009-06, Vol.4 (6), p.349-352</ispartof><rights>Springer Nature Limited 2009</rights><rights>Nature Publishing Group 2009.</rights><rights>Copyright Nature Publishing Group Jun 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-8553dd4e43dbff1c99905c740ef54ad97c8bd23064ad3aa16f72efae3558d36b3</citedby><cites>FETCH-LOGICAL-c482t-8553dd4e43dbff1c99905c740ef54ad97c8bd23064ad3aa16f72efae3558d36b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nnano.2009.72$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nnano.2009.72$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19498394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aldaye, Faisal A.</creatorcontrib><creatorcontrib>Lo, Pik Kwan</creatorcontrib><creatorcontrib>Karam, Pierre</creatorcontrib><creatorcontrib>McLaughlin, Christopher K.</creatorcontrib><creatorcontrib>Cosa, Gonzalo</creatorcontrib><creatorcontrib>Sleiman, Hanadi F.</creatorcontrib><title>Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character</title><title>Nature nanotechnology</title><addtitle>Nature Nanotech</addtitle><addtitle>Nat Nanotechnol</addtitle><description>DNA nanotubes can template the growth of nanowires
1
, orient transmembrane proteins for nuclear magnetic resonance determination
2
, and can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers
3
. Current methods for the construction of DNA nanotubes result in symmetrical and cylindrical assemblies that are entirely double-stranded
2
,
4
,
5
,
6
,
7
,
8
,
9
,
10
,
11
. Here, we report a modular approach to DNA nanotube synthesis that provides access to geometrically well-defined triangular and square-shaped DNA nanotubes. We also construct the first nanotube assemblies that can exist in double- and single-stranded forms with significantly different stiffness. This approach allows for parameters such as geometry, stiffness, and single- or double-stranded character to be fine-tuned, and could enable the creation of designer nanotubes for a range of applications, including the growth of nanowires of controlled shape, the loading and release of cargo, and the real-time modulation of stiffness and persistence length within DNA interconnects.
DNA nanotubes can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers. Researchers have now reported a modular approach to DNA nanotube synthesis that can create geometrically well-defined triangular and square tubes. The method allows parameters such as geometry, stiffness and single- or double-stranded character to be tuned, and could provide access to designer nanotubes for a range of applications.</description><subject>Assemblies</subject><subject>Chemistry and Materials Science</subject><subject>Construction methods</subject><subject>Current carriers</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>DNA biosynthesis</subject><subject>DNA, Circular - chemistry</subject><subject>DNA, Single-Stranded - chemistry</subject><subject>Drug carriers</subject><subject>Drug delivery</subject><subject>Geometry</subject><subject>Interconnections</subject><subject>letter</subject><subject>Materials Science</subject><subject>Membrane proteins</subject><subject>Microscopy, Atomic Force</subject><subject>Modular construction</subject><subject>Molecular motors</subject><subject>Nanotechnology</subject><subject>Nanotechnology - methods</subject><subject>Nanotechnology and Microengineering</subject><subject>Nanotubes</subject><subject>Nanotubes - chemistry</subject><subject>Nanowires</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Parameters</subject><subject>Stiffness</subject><subject>Synthesis</subject><subject>Tubes</subject><issn>1748-3387</issn><issn>1748-3395</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1vFSEUhomxsbW67NYQTdzNlc8Blk3V2qQfm7omDJy5vc1cqDAs-u_LeG9s0tgVh_M-eSB5ETqhZEUJ199idDGtGCFmpdgbdESV0B3nRr79N2t1iN6Xck-IZIaJd-iQGmE0N-IIDVcp1Mll7FMsc65-3qSI04i_X5_iRT3XAcqymGt0wwR4DWkLc37ELgZcNnE9QYdTxiHVFndN0gII2N-57PwM-QM6GN1U4OP-PEa_f_64PfvVXd6cX5ydXnZeaDZ3WkoeggDBwzCO1BtjiPRKEBilcMEor4fAOOnbhTtH-1ExGB1wKXXg_cCP0ded9yGnPxXKbLeb4mGaXIRUi2WkZ70ktIGfX4D3qebY_mZ1b7ShjLEGfXkNYkL1SnDGSKO6HeVzKiXDaB_yZuvyo6XELv3Yv_3YpR-rFuunvbUOWwjP9L6QBqx2QGlRXEN-fvb_xifWXZvj</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Aldaye, Faisal A.</creator><creator>Lo, Pik Kwan</creator><creator>Karam, Pierre</creator><creator>McLaughlin, Christopher K.</creator><creator>Cosa, Gonzalo</creator><creator>Sleiman, Hanadi F.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing 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Edition</collection><collection>Engineering Collection</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Nature nanotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aldaye, Faisal A.</au><au>Lo, Pik Kwan</au><au>Karam, Pierre</au><au>McLaughlin, Christopher K.</au><au>Cosa, Gonzalo</au><au>Sleiman, Hanadi F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character</atitle><jtitle>Nature nanotechnology</jtitle><stitle>Nature Nanotech</stitle><addtitle>Nat Nanotechnol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>4</volume><issue>6</issue><spage>349</spage><epage>352</epage><pages>349-352</pages><issn>1748-3387</issn><eissn>1748-3395</eissn><abstract>DNA nanotubes can template the growth of nanowires
1
, orient transmembrane proteins for nuclear magnetic resonance determination
2
, and can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers
3
. Current methods for the construction of DNA nanotubes result in symmetrical and cylindrical assemblies that are entirely double-stranded
2
,
4
,
5
,
6
,
7
,
8
,
9
,
10
,
11
. Here, we report a modular approach to DNA nanotube synthesis that provides access to geometrically well-defined triangular and square-shaped DNA nanotubes. We also construct the first nanotube assemblies that can exist in double- and single-stranded forms with significantly different stiffness. This approach allows for parameters such as geometry, stiffness, and single- or double-stranded character to be fine-tuned, and could enable the creation of designer nanotubes for a range of applications, including the growth of nanowires of controlled shape, the loading and release of cargo, and the real-time modulation of stiffness and persistence length within DNA interconnects.
DNA nanotubes can potentially act as stiff interconnects, tracks for molecular motors and nanoscale drug carriers. Researchers have now reported a modular approach to DNA nanotube synthesis that can create geometrically well-defined triangular and square tubes. The method allows parameters such as geometry, stiffness and single- or double-stranded character to be tuned, and could provide access to designer nanotubes for a range of applications.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19498394</pmid><doi>10.1038/nnano.2009.72</doi><tpages>4</tpages></addata></record> |
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| subjects | Assemblies Chemistry and Materials Science Construction methods Current carriers Deoxyribonucleic acid DNA DNA - chemistry DNA biosynthesis DNA, Circular - chemistry DNA, Single-Stranded - chemistry Drug carriers Drug delivery Geometry Interconnections letter Materials Science Membrane proteins Microscopy, Atomic Force Modular construction Molecular motors Nanotechnology Nanotechnology - methods Nanotechnology and Microengineering Nanotubes Nanotubes - chemistry Nanowires NMR Nuclear magnetic resonance Parameters Stiffness Synthesis Tubes |
| title | Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character |
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