The association study between DHCR24 polymorphisms and Alzheimer's disease

DHCR24 gene in chromosome 1 encodes seladin 1, a cholesterol synthesizing enzyme. Seladin 1 protects neurons from Aβ42 mediated toxicity and participates in regulation of Aβ42 formation by organizing the placement of APP cleaving β‐secretase in cholesterol‐rich detergent‐resistant membrane domains (...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-10, Vol.144B (7), p.906-910
Hauptverfasser:	Lämsä, R., Helisalmi, S., Hiltunen, M., Herukka, S.-K., Tapiola, T., Pirttilä, T., Vepsäläinen, S., Soininen, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1p33-p31.1 Adult and adolescent clinical studies Aged Alzheimer Disease - genetics Amyloid beta-Peptides - genetics Apolipoproteins E - genetics Biological and medical sciences biological markers Biomarkers - analysis Classical genetics, quantitative genetics, hybrids Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Fundamental and applied biological sciences. Psychology Gene Frequency genetic Genetics of eukaryotes. Biological and molecular evolution Genotype Haplotypes Human Humans Male Medical genetics Medical sciences Middle Aged Nerve Tissue Proteins - genetics Neurology Organic mental disorders. Neuropsychology Oxidoreductases Acting on CH-CH Group Donors - genetics Peptide Fragments - genetics Polymorphism, Single Nucleotide Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors tau Proteins - genetics
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