Species-level differences between mice and rats in regards to micronucleus induction with the hypothermia-inducing drug haloperidol

Species-level differences in response to micronucleus induction with haloperidol, a drug that can induce hypothermia, were investigated. Haloperidol was intraperitoneally (i.p.) administered to mice (12.5–50 mg/kg) and rats (25–100 mg/kg), and the rectal temperature was then measured. At every inves...

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Veröffentlicht in:Mutation research 2009-05, Vol.676 (1), p.102-105
Hauptverfasser: Asanami, Shougo, Shimono, Kazuyuki
Format: Artikel
Sprache:eng
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Zusammenfassung:Species-level differences in response to micronucleus induction with haloperidol, a drug that can induce hypothermia, were investigated. Haloperidol was intraperitoneally (i.p.) administered to mice (12.5–50 mg/kg) and rats (25–100 mg/kg), and the rectal temperature was then measured. At every investigated dose, haloperidol transiently decreased the rectal temperature in mice to less than 30 °C. However, the rectal temperature decreased to approximately 34 °C in rats. For micronucleus induction, haloperidol at doses of 25 and 50 mg/kg resulted in a statistically significant increase in micronucleated polychromatic erythrocyte frequency in the 48 h sampling group of mice, but not in rats. In addition, relatively large micronuclei (diameter of micronucleus > one-fourth the diameter of the cytoplasm) accounted for 46–47% of the induced micronuclei in mice, suggesting that hypothermia affected the mitotic apparatus. Thus, hypothermia can induce micronuclei in vivo as a secondary effect, and the hypothermic response to haloperidol in mice was stronger than that of rats. Micronuclei could only be induced in mice during this study. Therefore, species-level differences may exist in regards to micronucleus induction by hypothermia-inducing drugs.
ISSN:1383-5718
0027-5107
1879-3592
DOI:10.1016/j.mrgentox.2009.04.011