Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo

CYP2E1 metabolizes many low-molecular weight toxins and carcinogens. Some in vitro experiments suggest that CYP2E1 may be involved in the metabolic activation of diethylnitrosamine. However, there has been no direct evidence demonstrating a role for CYP2E1 in diethylnitrosamine-mediated carcinogenes...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-12, Vol.67 (23), p.11141-11146
Hauptverfasser:	Kang, Jin Seok, Wanibuchi, Hideki, Morimura, Keiichirou, Gonzalez, Frank J, Fukushima, Shoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology bcl-2-Associated X Protein - metabolism Blotting, Western Carcinogens - toxicity Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Caspase 3 - metabolism Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP2E1 - physiology Diethylnitrosamine - toxicity Genotype Liver Neoplasms, Experimental - enzymology Liver Neoplasms, Experimental - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism
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