Cytotoxicity and cytoprotective activity in naphthalenediols depends on their tendency to form naphthoquinones

We consider the cytotoxicity and the protection against oxidative stress for members of the naphthalenediol family and the known antioxidant epigallocatechin gallate (EGCG). Compounds include the 1,2-naphthalenediol (1,2-ND), 1,4-ND, 2,3-ND, 1,8-ND, and 1,4-dipropyl-2,3-naphthalenediol (DPND). The c...

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Veröffentlicht in:	Free radical biology & medicine 2005-11, Vol.39 (10), p.1368-1377
Hauptverfasser:	Flueraru, Mihaela, Chichirau, Alexandru, Chepelev, Leonid L., Willmore, William G., Durst, Tony, Charron, Martin, Barclay, L.R.C., Wright, James S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant activity Antioxidants - chemistry Bond dissociation enthalpy Catechin - analogs & derivatives Catechin - chemistry Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Free Radicals Hot Temperature Hydrogen-Ion Concentration Inhibitory Concentration 50 Models, Chemical Naphthalenediol (naphthohydroquinone) cytotoxicity Naphthols - chemistry Naphthoquinones - chemistry Oxidation-Reduction Oxidative Stress PC12 adrenal pheochromocytoma cells Quinone redox cycling Quinones - chemistry Rats Tetrazolium Salts - pharmacology Thiazoles - pharmacology Time Factors
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