Raft-dependent Endocytosis of Autocrine Motility Factor Is Phosphatidylinositol 3-Kinase-dependent in Breast Carcinoma Cells

Autocrine motility factor (AMF) is internalized via a receptor-mediated, dynamin-dependent, cholesterol-sensitive raft pathway to the smooth endoplasmic reticulum that is negatively regulated by caveolin-1. Expression of AMF and its receptor (AMFR) is associated with tumor progression and malignancy...

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Veröffentlicht in:	The Journal of biological chemistry 2007-10, Vol.282 (40), p.29305-29313
Hauptverfasser:	Kojic, Liliana D., Joshi, Bharat, Lajoie, Patrick, Le, Phuong U., Cox, Michael E., Turbin, Dmitry A., Wiseman, Sam M., Nabi, Ivan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma - metabolism Carcinoma - pathology Cell Line, Tumor Cell Separation Cytochalasin D - pharmacology DNA Fragmentation Endocytosis Flow Cytometry Gene Expression Regulation, Neoplastic Glucose-6-Phosphate Isomerase - metabolism Humans Membrane Microdomains - metabolism Oligonucleotide Array Sequence Analysis Phosphatidylinositol 3-Kinases - metabolism
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