Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia
Objective To investigate the association between iron supplementation during early pregnancy and the presence of de novo hypertension after 20 weeks’ gestation (either gestational hypertension or pre-eclampsia). Study design Retrospective cohort study. Methods This study retrospectively reviewed the...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2018-09, Vol.298 (3), p.545-550 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Jirakittidul, Preeyaporn Sirichotiyakul, Supatra Ruengorn, Chidchanok Techatraisak, Kitirat Wiriyasirivaj, Busaba |
| description | Objective
To investigate the association between iron supplementation during early pregnancy and the presence of de novo hypertension after 20 weeks’ gestation (either gestational hypertension or pre-eclampsia).
Study design
Retrospective cohort study.
Methods
This study retrospectively reviewed the medical records of non-anemic pregnant women who received first antenatal care at the Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand, during the June 2009–December 2010 study period. All included women had blood pressure and urine albumin level data that were recorded at each antenatal visit. The study population was divided into one of the two following groups: iron supplementation starting at gestational age (GA) |
| doi_str_mv | 10.1007/s00404-018-4821-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2061412770</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2061412770</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-a1d803aa279935c27cea475effc132ffa6258fa756f223f430d2c419a37a6f0e3</originalsourceid><addsrcrecordid>eNp1kctq3TAURUVpaG7TfkAnxdBJJ27OkWzJHpaQPiDQSTMWJ_LRjYMfqmQH7t9HxmkLhY4kobWXHluIdwifEMBcJoAKqhKwKatGYqlfiANWSpZgEF-KA7TbHLQ5F69TegBA2TT6lTiXbVtjZg7i8dp7dksx-6KP81SkNYSBR54WWvq87tbYT8eCKQ6nIkQ-TjS5U5F3lnsuOn7kYQ4bvhmOnPYYDcX9KXBceEqbhaZuC5fsBhpD6umNOPM0JH77PF6I2y_XP6--lTc_vn6_-nxTOmXkUhJ2DSgiadpW1U4ax1SZmr13qKT3pGXdeDK19lIqXynopKuwJWVIe2B1IT7u3hDnX2u-nh375HgYaOJ5TVaCxgqlMZDRD_-gD_Ma81MyJTXWCmrdZgp3ysU5pcjehtiPFE8WwW6l2L0Um0uxWylW58z7Z_N6N3L3J_G7hQzIHUhh-22Of4_-v_UJrcKY3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261530569</pqid></control><display><type>article</type><title>Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Jirakittidul, Preeyaporn ; Sirichotiyakul, Supatra ; Ruengorn, Chidchanok ; Techatraisak, Kitirat ; Wiriyasirivaj, Busaba</creator><creatorcontrib>Jirakittidul, Preeyaporn ; Sirichotiyakul, Supatra ; Ruengorn, Chidchanok ; Techatraisak, Kitirat ; Wiriyasirivaj, Busaba</creatorcontrib><description>Objective
To investigate the association between iron supplementation during early pregnancy and the presence of de novo hypertension after 20 weeks’ gestation (either gestational hypertension or pre-eclampsia).
Study design
Retrospective cohort study.
Methods
This study retrospectively reviewed the medical records of non-anemic pregnant women who received first antenatal care at the Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand, during the June 2009–December 2010 study period. All included women had blood pressure and urine albumin level data that were recorded at each antenatal visit. The study population was divided into one of the two following groups: iron supplementation starting at gestational age (GA) < 16 weeks (study group) or GA ≥ 16 weeks (control group). A comparison of the proportion of de novo hypertension arising after 20 weeks’ gestation was then performed between groups.
Results
Four hundred non-anemic pregnant women were included, with 200 patients allocated to each groups. The overall incidence of de novo hypertension after 20 weeks’ gestation was 10% (40/400), with significantly higher prevalence in the study group than that in the control group [13.5% (27/200) vs. 6.5% (13/200); relative risk: 2.14, 95%, CI 1.22–3.73;
p
= 0.008]. None of the women in this study developed anemia at time of delivery. There was no significant difference between groups for GA at delivery, birth weight, or birth asphyxia.
Conclusion
In our study population, iron supplementation before 16 weeks’ GA was significantly associated with increased risk of developing de novo hypertension after 20 weeks’ gestation.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-018-4821-6</identifier><identifier>PMID: 29951711</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Blood Pressure ; Dietary Supplements ; Endocrinology ; Female ; Gestational Age ; Gynecology ; Health risk assessment ; Human Genetics ; Humans ; Hypertension ; Hypertension, Pregnancy-Induced - blood ; Hypertension, Pregnancy-Induced - epidemiology ; Iron ; Iron - administration & dosage ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pre-Eclampsia - blood ; Pre-Eclampsia - epidemiology ; Preeclampsia ; Pregnancy ; Prenatal Care ; Retrospective Studies ; Thailand ; Young Adult</subject><ispartof>Archives of gynecology and obstetrics, 2018-09, Vol.298 (3), p.545-550</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-a1d803aa279935c27cea475effc132ffa6258fa756f223f430d2c419a37a6f0e3</citedby><cites>FETCH-LOGICAL-c372t-a1d803aa279935c27cea475effc132ffa6258fa756f223f430d2c419a37a6f0e3</cites><orcidid>0000-0003-0221-9789</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-018-4821-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-018-4821-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29951711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jirakittidul, Preeyaporn</creatorcontrib><creatorcontrib>Sirichotiyakul, Supatra</creatorcontrib><creatorcontrib>Ruengorn, Chidchanok</creatorcontrib><creatorcontrib>Techatraisak, Kitirat</creatorcontrib><creatorcontrib>Wiriyasirivaj, Busaba</creatorcontrib><title>Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Objective
To investigate the association between iron supplementation during early pregnancy and the presence of de novo hypertension after 20 weeks’ gestation (either gestational hypertension or pre-eclampsia).
Study design
Retrospective cohort study.
Methods
This study retrospectively reviewed the medical records of non-anemic pregnant women who received first antenatal care at the Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand, during the June 2009–December 2010 study period. All included women had blood pressure and urine albumin level data that were recorded at each antenatal visit. The study population was divided into one of the two following groups: iron supplementation starting at gestational age (GA) < 16 weeks (study group) or GA ≥ 16 weeks (control group). A comparison of the proportion of de novo hypertension arising after 20 weeks’ gestation was then performed between groups.
Results
Four hundred non-anemic pregnant women were included, with 200 patients allocated to each groups. The overall incidence of de novo hypertension after 20 weeks’ gestation was 10% (40/400), with significantly higher prevalence in the study group than that in the control group [13.5% (27/200) vs. 6.5% (13/200); relative risk: 2.14, 95%, CI 1.22–3.73;
p
= 0.008]. None of the women in this study developed anemia at time of delivery. There was no significant difference between groups for GA at delivery, birth weight, or birth asphyxia.
Conclusion
In our study population, iron supplementation before 16 weeks’ GA was significantly associated with increased risk of developing de novo hypertension after 20 weeks’ gestation.</description><subject>Adult</subject><subject>Blood Pressure</subject><subject>Dietary Supplements</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pregnancy-Induced - blood</subject><subject>Hypertension, Pregnancy-Induced - epidemiology</subject><subject>Iron</subject><subject>Iron - administration & dosage</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Prenatal Care</subject><subject>Retrospective Studies</subject><subject>Thailand</subject><subject>Young Adult</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kctq3TAURUVpaG7TfkAnxdBJJ27OkWzJHpaQPiDQSTMWJ_LRjYMfqmQH7t9HxmkLhY4kobWXHluIdwifEMBcJoAKqhKwKatGYqlfiANWSpZgEF-KA7TbHLQ5F69TegBA2TT6lTiXbVtjZg7i8dp7dksx-6KP81SkNYSBR54WWvq87tbYT8eCKQ6nIkQ-TjS5U5F3lnsuOn7kYQ4bvhmOnPYYDcX9KXBceEqbhaZuC5fsBhpD6umNOPM0JH77PF6I2y_XP6--lTc_vn6_-nxTOmXkUhJ2DSgiadpW1U4ax1SZmr13qKT3pGXdeDK19lIqXynopKuwJWVIe2B1IT7u3hDnX2u-nh375HgYaOJ5TVaCxgqlMZDRD_-gD_Ma81MyJTXWCmrdZgp3ysU5pcjehtiPFE8WwW6l2L0Um0uxWylW58z7Z_N6N3L3J_G7hQzIHUhh-22Of4_-v_UJrcKY3A</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Jirakittidul, Preeyaporn</creator><creator>Sirichotiyakul, Supatra</creator><creator>Ruengorn, Chidchanok</creator><creator>Techatraisak, Kitirat</creator><creator>Wiriyasirivaj, Busaba</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0221-9789</orcidid></search><sort><creationdate>20180901</creationdate><title>Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia</title><author>Jirakittidul, Preeyaporn ; Sirichotiyakul, Supatra ; Ruengorn, Chidchanok ; Techatraisak, Kitirat ; Wiriyasirivaj, Busaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-a1d803aa279935c27cea475effc132ffa6258fa756f223f430d2c419a37a6f0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Blood Pressure</topic><topic>Dietary Supplements</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pregnancy-Induced - blood</topic><topic>Hypertension, Pregnancy-Induced - epidemiology</topic><topic>Iron</topic><topic>Iron - administration & dosage</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Prenatal Care</topic><topic>Retrospective Studies</topic><topic>Thailand</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jirakittidul, Preeyaporn</creatorcontrib><creatorcontrib>Sirichotiyakul, Supatra</creatorcontrib><creatorcontrib>Ruengorn, Chidchanok</creatorcontrib><creatorcontrib>Techatraisak, Kitirat</creatorcontrib><creatorcontrib>Wiriyasirivaj, Busaba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jirakittidul, Preeyaporn</au><au>Sirichotiyakul, Supatra</au><au>Ruengorn, Chidchanok</au><au>Techatraisak, Kitirat</au><au>Wiriyasirivaj, Busaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>298</volume><issue>3</issue><spage>545</spage><epage>550</epage><pages>545-550</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Objective
To investigate the association between iron supplementation during early pregnancy and the presence of de novo hypertension after 20 weeks’ gestation (either gestational hypertension or pre-eclampsia).
Study design
Retrospective cohort study.
Methods
This study retrospectively reviewed the medical records of non-anemic pregnant women who received first antenatal care at the Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand, during the June 2009–December 2010 study period. All included women had blood pressure and urine albumin level data that were recorded at each antenatal visit. The study population was divided into one of the two following groups: iron supplementation starting at gestational age (GA) < 16 weeks (study group) or GA ≥ 16 weeks (control group). A comparison of the proportion of de novo hypertension arising after 20 weeks’ gestation was then performed between groups.
Results
Four hundred non-anemic pregnant women were included, with 200 patients allocated to each groups. The overall incidence of de novo hypertension after 20 weeks’ gestation was 10% (40/400), with significantly higher prevalence in the study group than that in the control group [13.5% (27/200) vs. 6.5% (13/200); relative risk: 2.14, 95%, CI 1.22–3.73;
p
= 0.008]. None of the women in this study developed anemia at time of delivery. There was no significant difference between groups for GA at delivery, birth weight, or birth asphyxia.
Conclusion
In our study population, iron supplementation before 16 weeks’ GA was significantly associated with increased risk of developing de novo hypertension after 20 weeks’ gestation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29951711</pmid><doi>10.1007/s00404-018-4821-6</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0221-9789</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2018-09, Vol.298 (3), p.545-550 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2061412770 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Blood Pressure Dietary Supplements Endocrinology Female Gestational Age Gynecology Health risk assessment Human Genetics Humans Hypertension Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - epidemiology Iron Iron - administration & dosage Maternal-Fetal Medicine Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pre-Eclampsia - blood Pre-Eclampsia - epidemiology Preeclampsia Pregnancy Prenatal Care Retrospective Studies Thailand Young Adult |
| title | Effect of iron supplementation during early pregnancy on the development of gestational hypertension and pre-eclampsia |
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