Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)
Rainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous series of perfluoroalkyl carboxylates and sulfonates in a flow‐through system to determine compound‐specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulat...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2003-01, Vol.22 (1), p.196-204 |
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| creator | Martin, Jonathan W. Mabury, Scott A. Solomon, Keith R. Muir, Derek C. G. |
| description | Rainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous series of perfluoroalkyl carboxylates and sulfonates in a flow‐through system to determine compound‐specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest extent in blood > kidney > liver > gall bladder. Carboxylates and sulfonates with perfluoroalkyl chain lengths shorter than seven and six carbons, respectively, could not be detected in most tissues and were considered to have insignificant bioconcentration factors (BCFs). For detectable PFAs, carcass BCFs increased with increasing length of the perfluoroalkyl chain, ranging from 4.0 to 23,000, based on wet weight concentrations. Carboxylate carcass BCFs increased by a factor of eight for each additional carbon in the perfluoroalkyl chain between 8 and 12 carbons, but this relationship deviated from linearity for the longest PFA tested, possibly because of decreased gill permeability. In general, half‐lives (3.9–28 d) and uptake rates (0.053–1,700 L/kg/d) also increased with increasing length of the perfluoroalkyl chain in all tissues. Sulfonates had greater BCFs, half‐lives, and rates of uptake than the corresponding carboxylate of equal perfluoroalkyl chain length, indicating that hydrophobicity, as predicted by the critical micelle concentration, is not the only determinant of PFA bioaccumulation potential and that the acid function must be considered. |
| doi_str_mv | 10.1002/etc.5620220126 |
| format | Article |
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G.</creator><creatorcontrib>Martin, Jonathan W. ; Mabury, Scott A. ; Solomon, Keith R. ; Muir, Derek C. G.</creatorcontrib><description>Rainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous series of perfluoroalkyl carboxylates and sulfonates in a flow‐through system to determine compound‐specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest extent in blood > kidney > liver > gall bladder. Carboxylates and sulfonates with perfluoroalkyl chain lengths shorter than seven and six carbons, respectively, could not be detected in most tissues and were considered to have insignificant bioconcentration factors (BCFs). For detectable PFAs, carcass BCFs increased with increasing length of the perfluoroalkyl chain, ranging from 4.0 to 23,000, based on wet weight concentrations. Carboxylate carcass BCFs increased by a factor of eight for each additional carbon in the perfluoroalkyl chain between 8 and 12 carbons, but this relationship deviated from linearity for the longest PFA tested, possibly because of decreased gill permeability. In general, half‐lives (3.9–28 d) and uptake rates (0.053–1,700 L/kg/d) also increased with increasing length of the perfluoroalkyl chain in all tissues. Sulfonates had greater BCFs, half‐lives, and rates of uptake than the corresponding carboxylate of equal perfluoroalkyl chain length, indicating that hydrophobicity, as predicted by the critical micelle concentration, is not the only determinant of PFA bioaccumulation potential and that the acid function must be considered.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.5620220126</identifier><identifier>PMID: 12503765</identifier><identifier>CODEN: ETOCDK</identifier><language>eng</language><publisher>Hoboken: Wiley Periodicals, Inc</publisher><subject>Acids - pharmacokinetics ; Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Bioaccumulation ; Biological and medical sciences ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on protozoa and invertebrates ; Effects of pollution and side effects of pesticides on vertebrates ; Fish ; Fluorocarbons - pharmacokinetics ; Fundamental and applied biological sciences. Psychology ; Half-Life ; Kinetics ; Oncorhynchus mykiss ; Oncorhynchus mykiss - physiology ; Perfluorinated acid ; perfluorinated acids ; perfluoroalkyl carboxylates ; perfluoroalkyl sulfonates ; Perfluorooctane sulfonate ; Surfactants ; Tissue Distribution ; Water Pollutants, Chemical - pharmacokinetics</subject><ispartof>Environmental toxicology and chemistry, 2003-01, Vol.22 (1), p.196-204</ispartof><rights>Copyright © 2003 SETAC</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5376-d016b0f048e81fc41cc6fae9d467172957c1e162fefc998c2802c0b18742e1713</citedby><cites>FETCH-LOGICAL-c5376-d016b0f048e81fc41cc6fae9d467172957c1e162fefc998c2802c0b18742e1713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.5620220126$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.5620220126$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14418644$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12503765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Jonathan W.</creatorcontrib><creatorcontrib>Mabury, Scott A.</creatorcontrib><creatorcontrib>Solomon, Keith R.</creatorcontrib><creatorcontrib>Muir, Derek C. G.</creatorcontrib><title>Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)</title><title>Environmental toxicology and chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>Rainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous series of perfluoroalkyl carboxylates and sulfonates in a flow‐through system to determine compound‐specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest extent in blood > kidney > liver > gall bladder. Carboxylates and sulfonates with perfluoroalkyl chain lengths shorter than seven and six carbons, respectively, could not be detected in most tissues and were considered to have insignificant bioconcentration factors (BCFs). For detectable PFAs, carcass BCFs increased with increasing length of the perfluoroalkyl chain, ranging from 4.0 to 23,000, based on wet weight concentrations. Carboxylate carcass BCFs increased by a factor of eight for each additional carbon in the perfluoroalkyl chain between 8 and 12 carbons, but this relationship deviated from linearity for the longest PFA tested, possibly because of decreased gill permeability. In general, half‐lives (3.9–28 d) and uptake rates (0.053–1,700 L/kg/d) also increased with increasing length of the perfluoroalkyl chain in all tissues. Sulfonates had greater BCFs, half‐lives, and rates of uptake than the corresponding carboxylate of equal perfluoroalkyl chain length, indicating that hydrophobicity, as predicted by the critical micelle concentration, is not the only determinant of PFA bioaccumulation potential and that the acid function must be considered.</description><subject>Acids - pharmacokinetics</subject><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Bioaccumulation</subject><subject>Biological and medical sciences</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on protozoa and invertebrates</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Fish</subject><subject>Fluorocarbons - pharmacokinetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Half-Life</subject><subject>Kinetics</subject><subject>Oncorhynchus mykiss</subject><subject>Oncorhynchus mykiss - physiology</subject><subject>Perfluorinated acid</subject><subject>perfluorinated acids</subject><subject>perfluoroalkyl carboxylates</subject><subject>perfluoroalkyl sulfonates</subject><subject>Perfluorooctane sulfonate</subject><subject>Surfactants</subject><subject>Tissue Distribution</subject><subject>Water Pollutants, Chemical - pharmacokinetics</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1vFDEQxS0EIkegpURuiKDYw-P1-qMkESREUUIButLyem1ismcf9q7C_fcY7sQpVaqRRr_35mkeQq-BLIEQ-sFNdtlxSiglQPkTtICuo43kIJ-iBREtaQTl8gi9KOUnIcCVUs_REdCOtIJ3C_TjNCSbonVxymYKKWITBzyFUmaHh1CmHPr53z55vHHZj3PKIZrJDdjYMBQcIs4mxD7d4ymnecLvbqJN-XYb7e1c8Hp7V83ev0TPvBmLe7Wfx-j750_fzi6aq5vzL2cfrxrb1UDNUCP2xBMmnQRvGVjLvXFqYFyAoKoTFhxw6p23SklLJaGW9CAFow4EtMfoZOe7yenX7Mqk16FYN44mujQXTQkH2hL1KAiMs1ZJWcHlDrQ5lZKd15sc1iZvNRD9twNdO9CHDqrgzd557tduOOD7p1fg7R4wxZrRZxNtKAeOMZCcscqpHXcfRrd95Kyu5IMQzU5bK3S__2tNvtNctKLTq-tzLdhXslpdXuqL9g8qpa_c</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Martin, Jonathan W.</creator><creator>Mabury, Scott A.</creator><creator>Solomon, Keith R.</creator><creator>Muir, Derek C. G.</creator><general>Wiley Periodicals, Inc</general><general>SETAC</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>200301</creationdate><title>Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)</title><author>Martin, Jonathan W. ; Mabury, Scott A. ; Solomon, Keith R. ; Muir, Derek C. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5376-d016b0f048e81fc41cc6fae9d467172957c1e162fefc998c2802c0b18742e1713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acids - pharmacokinetics</topic><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Bioaccumulation</topic><topic>Biological and medical sciences</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on protozoa and invertebrates</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Fish</topic><topic>Fluorocarbons - pharmacokinetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Half-Life</topic><topic>Kinetics</topic><topic>Oncorhynchus mykiss</topic><topic>Oncorhynchus mykiss - physiology</topic><topic>Perfluorinated acid</topic><topic>perfluorinated acids</topic><topic>perfluoroalkyl carboxylates</topic><topic>perfluoroalkyl sulfonates</topic><topic>Perfluorooctane sulfonate</topic><topic>Surfactants</topic><topic>Tissue Distribution</topic><topic>Water Pollutants, Chemical - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Jonathan W.</creatorcontrib><creatorcontrib>Mabury, Scott A.</creatorcontrib><creatorcontrib>Solomon, Keith R.</creatorcontrib><creatorcontrib>Muir, Derek C. G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Jonathan W.</au><au>Mabury, Scott A.</au><au>Solomon, Keith R.</au><au>Muir, Derek C. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>2003-01</date><risdate>2003</risdate><volume>22</volume><issue>1</issue><spage>196</spage><epage>204</epage><pages>196-204</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><coden>ETOCDK</coden><abstract>Rainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous series of perfluoroalkyl carboxylates and sulfonates in a flow‐through system to determine compound‐specific tissue distribution and bioconcentration parameters for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest extent in blood > kidney > liver > gall bladder. Carboxylates and sulfonates with perfluoroalkyl chain lengths shorter than seven and six carbons, respectively, could not be detected in most tissues and were considered to have insignificant bioconcentration factors (BCFs). For detectable PFAs, carcass BCFs increased with increasing length of the perfluoroalkyl chain, ranging from 4.0 to 23,000, based on wet weight concentrations. Carboxylate carcass BCFs increased by a factor of eight for each additional carbon in the perfluoroalkyl chain between 8 and 12 carbons, but this relationship deviated from linearity for the longest PFA tested, possibly because of decreased gill permeability. In general, half‐lives (3.9–28 d) and uptake rates (0.053–1,700 L/kg/d) also increased with increasing length of the perfluoroalkyl chain in all tissues. Sulfonates had greater BCFs, half‐lives, and rates of uptake than the corresponding carboxylate of equal perfluoroalkyl chain length, indicating that hydrophobicity, as predicted by the critical micelle concentration, is not the only determinant of PFA bioaccumulation potential and that the acid function must be considered.</abstract><cop>Hoboken</cop><pub>Wiley Periodicals, Inc</pub><pmid>12503765</pmid><doi>10.1002/etc.5620220126</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0730-7268 |
| ispartof | Environmental toxicology and chemistry, 2003-01, Vol.22 (1), p.196-204 |
| issn | 0730-7268 1552-8618 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acids - pharmacokinetics Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Bioaccumulation Biological and medical sciences Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Effects of pollution and side effects of pesticides on vertebrates Fish Fluorocarbons - pharmacokinetics Fundamental and applied biological sciences. Psychology Half-Life Kinetics Oncorhynchus mykiss Oncorhynchus mykiss - physiology Perfluorinated acid perfluorinated acids perfluoroalkyl carboxylates perfluoroalkyl sulfonates Perfluorooctane sulfonate Surfactants Tissue Distribution Water Pollutants, Chemical - pharmacokinetics |
| title | Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss) |
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