Immunohistochemical expression of MTA1 and MTA3 in placental tissue of normal and preeclamptic pregnancies
The aim of this preliminary study was to evaluate and compare MTAI andMTA3 antigens expression in normal and preeclamptic placentas in order to demonstrate their possible functional relationship during pathogenesis of preeclampsia. A series including 20 paraffin-embedded placentas, ten of which orig...
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| Veröffentlicht in: | Clinical and experimental obstetrics & gynecology 2017-01, Vol.44 (3), p.370-373 |
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| container_title | Clinical and experimental obstetrics & gynecology |
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| creator | Liiberis, A Lambropoulou, M Tsikouras, P Mylonas, I Trypsianis, G Papadopoulos, N Galazios, G |
| description | The aim of this preliminary study was to evaluate and compare MTAI andMTA3 antigens expression in normal and preeclamptic placentas in order to demonstrate their possible functional relationship during pathogenesis of preeclampsia.
A series including 20 paraffin-embedded placentas, ten of which originated from normal patients and ten from preeclamptic patients, that were examined by immunohistochemistry using the polyclonal antibodies MTAI and MTA3.
The results of this study showed a positive nuclear staining reaction against MTAI and MTA3 in both normal and preeclamptic placentas. However, in preeclamptic chorionic villi, cytotrophoblast and syncytiotrophoblast cells demonstrated increased expression of MTAI and MTA3 than in normal ones.
The present observations indicate a potential role for MTAI and MTA3 for normal human placental function, playing an essential role in the pathogenesis of preeclampsia. Nevertheless, the precise relationship between these antigens' expression and pathological pregnancies remains to be elucidated. |
| doi_str_mv | 10.12891/ceog3405.2017 |
| format | Article |
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A series including 20 paraffin-embedded placentas, ten of which originated from normal patients and ten from preeclamptic patients, that were examined by immunohistochemistry using the polyclonal antibodies MTAI and MTA3.
The results of this study showed a positive nuclear staining reaction against MTAI and MTA3 in both normal and preeclamptic placentas. However, in preeclamptic chorionic villi, cytotrophoblast and syncytiotrophoblast cells demonstrated increased expression of MTAI and MTA3 than in normal ones.
The present observations indicate a potential role for MTAI and MTA3 for normal human placental function, playing an essential role in the pathogenesis of preeclampsia. Nevertheless, the precise relationship between these antigens' expression and pathological pregnancies remains to be elucidated.</description><identifier>ISSN: 0390-6663</identifier><identifier>DOI: 10.12891/ceog3405.2017</identifier><identifier>PMID: 29949275</identifier><language>eng</language><publisher>Singapore</publisher><subject>Adult ; Case-Control Studies ; Female ; Histone Deacetylases - metabolism ; Humans ; Immunohistochemistry ; Neoplasm Proteins - metabolism ; Placenta - metabolism ; Pre-Eclampsia - metabolism ; Pregnancy ; Repressor Proteins - metabolism ; Trans-Activators ; Trophoblasts</subject><ispartof>Clinical and experimental obstetrics & gynecology, 2017-01, Vol.44 (3), p.370-373</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29949275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liiberis, A</creatorcontrib><creatorcontrib>Lambropoulou, M</creatorcontrib><creatorcontrib>Tsikouras, P</creatorcontrib><creatorcontrib>Mylonas, I</creatorcontrib><creatorcontrib>Trypsianis, G</creatorcontrib><creatorcontrib>Papadopoulos, N</creatorcontrib><creatorcontrib>Galazios, G</creatorcontrib><title>Immunohistochemical expression of MTA1 and MTA3 in placental tissue of normal and preeclamptic pregnancies</title><title>Clinical and experimental obstetrics & gynecology</title><addtitle>Clin Exp Obstet Gynecol</addtitle><description>The aim of this preliminary study was to evaluate and compare MTAI andMTA3 antigens expression in normal and preeclamptic placentas in order to demonstrate their possible functional relationship during pathogenesis of preeclampsia.
A series including 20 paraffin-embedded placentas, ten of which originated from normal patients and ten from preeclamptic patients, that were examined by immunohistochemistry using the polyclonal antibodies MTAI and MTA3.
The results of this study showed a positive nuclear staining reaction against MTAI and MTA3 in both normal and preeclamptic placentas. However, in preeclamptic chorionic villi, cytotrophoblast and syncytiotrophoblast cells demonstrated increased expression of MTAI and MTA3 than in normal ones.
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A series including 20 paraffin-embedded placentas, ten of which originated from normal patients and ten from preeclamptic patients, that were examined by immunohistochemistry using the polyclonal antibodies MTAI and MTA3.
The results of this study showed a positive nuclear staining reaction against MTAI and MTA3 in both normal and preeclamptic placentas. However, in preeclamptic chorionic villi, cytotrophoblast and syncytiotrophoblast cells demonstrated increased expression of MTAI and MTA3 than in normal ones.
The present observations indicate a potential role for MTAI and MTA3 for normal human placental function, playing an essential role in the pathogenesis of preeclampsia. Nevertheless, the precise relationship between these antigens' expression and pathological pregnancies remains to be elucidated.</abstract><cop>Singapore</cop><pmid>29949275</pmid><doi>10.12891/ceog3405.2017</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and experimental obstetrics & gynecology, 2017-01, Vol.44 (3), p.370-373 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Case-Control Studies Female Histone Deacetylases - metabolism Humans Immunohistochemistry Neoplasm Proteins - metabolism Placenta - metabolism Pre-Eclampsia - metabolism Pregnancy Repressor Proteins - metabolism Trans-Activators Trophoblasts |
| title | Immunohistochemical expression of MTA1 and MTA3 in placental tissue of normal and preeclamptic pregnancies |
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