Comparison of lactate and β-hydroxybutyrate in the treatment of concanavalin-A induced hepatitis

Simple metabolites released during physical exercise and fasting like lactate (Lac) and β-hydroxybutyrate (BHB) have recently been shown to possess anti-inflammatory properties. However, the effects of these metabolites in immune mediated hepatitis are still unknown. Accordingly, we investigated the...

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Veröffentlicht in:	International immunopharmacology 2018-08, Vol.61, p.376-384
Hauptverfasser:	Hazem, Sara H., Hamed, Mohamed F., Saad, Mohamed-Ahdy A., Gameil, Nariman M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Concanavalin A Cytokines Electron microscopy Hepatitis Immune system Infiltration Inflammation Interleukin 12 Interleukin 6 Intoxication Intravenous administration Lactate Lactic acid Leukocytes (neutrophilic) Liver MAPK Medical treatment Metabolites Mice Monocytes NF-κB protein Oxidative stress Phosphorylation Physical exercise Proteins Stat3 protein Sterile inflammation Transcription activation Tumor necrosis factor-α β-Hydroxybutyrate
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