Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

Purpose: Despite the challenge to directly target mutant KRAS due to its high GTP affinity, some agents are under development against downstream signaling pathways, such as MEK inhibitors. However, it remains controversial whether MEK inhibitors can boost current chemotherapy in KRAS-mutant lung tum...

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Veröffentlicht in:	Clinical cancer research 2018-10, Vol.24 (19), p.4854-4864
Hauptverfasser:	Li, Shuai, Liu, Shengwu, Deng, Jiehui, Akbay, Esra A., Hai, Josephine, Ambrogio, Chiara, Zhang, Long, Zhou, Fangyu, Jenkins, Russell W., Adeegbe, Dennis O., Gao, Peng, Wang, Xiaoen, Paweletz, Cloud P., Herter-Sprie, Grit S., Chen, Ting, Gutiérrez-Quiceno, Laura, Zhang, Yanxi, Merlino, Ashley A., Quinn, Max M., Zeng, Yu, Yu, Xiaoting, Liu, Yuting, Fan, Lichao, Aguirre, Andrew J., Barbie, David A., Yi, Xianghua, Wong, Kwok-Kin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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