Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML

We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-pos...

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Veröffentlicht in:	Journal of neurology 2018-08, Vol.265 (8), p.1880-1882
Hauptverfasser:	Motte, Jeremias, Kneiphof, Janina, Straßburger-Krogias, Katrin, Klasing, Anja, Adams, Ortwin, Haghikia, Aiden, Gold, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Archetypes CD8 antigen Cerebrospinal fluid Cidofovir Deoxyribonucleic acid DNA Encephalitis Lymphocytes T Lymphopenia Medicine Medicine & Public Health Mefloquine Multiple sclerosis Neurology Neuroradiology Neurosciences Original Communication Patients Viral infections
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