Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML
We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-pos...
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| Veröffentlicht in: | Journal of neurology 2018-08, Vol.265 (8), p.1880-1882 |
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| container_title | Journal of neurology |
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| creator | Motte, Jeremias Kneiphof, Janina Straßburger-Krogias, Katrin Klasing, Anja Adams, Ortwin Haghikia, Aiden Gold, Ralf |
| description | We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloquine, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF. |
| doi_str_mv | 10.1007/s00415-018-8931-7 |
| format | Article |
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Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloquine, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-018-8931-7</identifier><identifier>PMID: 29948248</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Antibodies, Viral - blood ; Antibodies, Viral - cerebrospinal fluid ; Archetypes ; CD8 antigen ; Cerebrospinal fluid ; Cidofovir ; Deoxyribonucleic acid ; Dimethyl Fumarate - therapeutic use ; DNA ; DNA, Viral - blood ; DNA, Viral - cerebrospinal fluid ; Encephalitis ; Female ; Humans ; Immunosuppressive Agents - therapeutic use ; JC Virus - genetics ; JC Virus - immunology ; Lymphocytes T ; Lymphopenia ; Medicine ; Medicine & Public Health ; Mefloquine ; Multiple sclerosis ; Multiple Sclerosis, Relapsing-Remitting - complications ; Multiple Sclerosis, Relapsing-Remitting - drug therapy ; Multiple Sclerosis, Relapsing-Remitting - immunology ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Patients ; Polyomavirus Infections - complications ; Polyomavirus Infections - drug therapy ; Polyomavirus Infections - immunology ; Tumor Virus Infections - complications ; Tumor Virus Infections - drug therapy ; Tumor Virus Infections - immunology ; Viral infections</subject><ispartof>Journal of neurology, 2018-08, Vol.265 (8), p.1880-1882</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Journal of Neurology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-55e3ba5c3a0f7878a47c72495aef7333ff2a8a9e8c55e3efb4ea85f5818c38913</citedby><cites>FETCH-LOGICAL-c372t-55e3ba5c3a0f7878a47c72495aef7333ff2a8a9e8c55e3efb4ea85f5818c38913</cites><orcidid>0000-0002-6624-8565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-018-8931-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-018-8931-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29948248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motte, Jeremias</creatorcontrib><creatorcontrib>Kneiphof, Janina</creatorcontrib><creatorcontrib>Straßburger-Krogias, Katrin</creatorcontrib><creatorcontrib>Klasing, Anja</creatorcontrib><creatorcontrib>Adams, Ortwin</creatorcontrib><creatorcontrib>Haghikia, Aiden</creatorcontrib><creatorcontrib>Gold, Ralf</creatorcontrib><title>Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloquine, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF.</description><subject>Aged</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - cerebrospinal fluid</subject><subject>Archetypes</subject><subject>CD8 antigen</subject><subject>Cerebrospinal fluid</subject><subject>Cidofovir</subject><subject>Deoxyribonucleic acid</subject><subject>Dimethyl Fumarate - therapeutic use</subject><subject>DNA</subject><subject>DNA, Viral - blood</subject><subject>DNA, Viral - cerebrospinal fluid</subject><subject>Encephalitis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>JC Virus - genetics</subject><subject>JC Virus - immunology</subject><subject>Lymphocytes T</subject><subject>Lymphopenia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mefloquine</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis, Relapsing-Remitting - complications</subject><subject>Multiple Sclerosis, Relapsing-Remitting - drug therapy</subject><subject>Multiple Sclerosis, Relapsing-Remitting - immunology</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Patients</subject><subject>Polyomavirus Infections - complications</subject><subject>Polyomavirus Infections - drug therapy</subject><subject>Polyomavirus Infections - immunology</subject><subject>Tumor Virus Infections - complications</subject><subject>Tumor Virus Infections - drug therapy</subject><subject>Tumor Virus Infections - immunology</subject><subject>Viral infections</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV9rFDEUxUNR7Nr6AfoiAV98Gc3fTeZRVq3KFgvV55DN3nRTZibTJFPZr-CnNtNtFQo-Xbjnd8-FcxA6o-QdJUS9z4QIKhtCdaNbTht1hBZUcNZQIdtnaEG4II3kUhyjlznfEEJ0FV6gY9a2QjOhF-j3RyjgSogDjh5_W-G7kKaMbXI7KPsRcBiwgwSbFPMYBtth301hO68tvrjCoy0BhoJ_hbLD29BD2e07P_U22QK4JLClf9TjVHC378ddHGEIFseEc7ge8vz58mJ9ip5722V49TBP0M_Pn36svjTr7-dfVx_WjeOKlUZK4BsrHbfEK620FcopJlppwSvOuffMatuCdjMJfiPAaumlptpx3VJ-gt4efMcUbyfIxfQhO-g6O0CcsmFkSfRyKe_RN0_QmzilmsJMSalUywmrFD1QroaUE3gzplAT2BtKzFyUORRlalFmLsqoevP6wXna9LD9e_HYTAXYAchVGq4h_Xv9f9c_r7afow</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Motte, Jeremias</creator><creator>Kneiphof, Janina</creator><creator>Straßburger-Krogias, Katrin</creator><creator>Klasing, Anja</creator><creator>Adams, Ortwin</creator><creator>Haghikia, Aiden</creator><creator>Gold, Ralf</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6624-8565</orcidid></search><sort><creationdate>20180801</creationdate><title>Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML</title><author>Motte, Jeremias ; Kneiphof, Janina ; Straßburger-Krogias, Katrin ; Klasing, Anja ; Adams, Ortwin ; Haghikia, Aiden ; Gold, Ralf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-55e3ba5c3a0f7878a47c72495aef7333ff2a8a9e8c55e3efb4ea85f5818c38913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - cerebrospinal fluid</topic><topic>Archetypes</topic><topic>CD8 antigen</topic><topic>Cerebrospinal fluid</topic><topic>Cidofovir</topic><topic>Deoxyribonucleic acid</topic><topic>Dimethyl Fumarate - therapeutic use</topic><topic>DNA</topic><topic>DNA, Viral - blood</topic><topic>DNA, Viral - cerebrospinal fluid</topic><topic>Encephalitis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>JC Virus - genetics</topic><topic>JC Virus - immunology</topic><topic>Lymphocytes T</topic><topic>Lymphopenia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mefloquine</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis, Relapsing-Remitting - complications</topic><topic>Multiple Sclerosis, Relapsing-Remitting - drug therapy</topic><topic>Multiple Sclerosis, Relapsing-Remitting - immunology</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Patients</topic><topic>Polyomavirus Infections - complications</topic><topic>Polyomavirus Infections - drug therapy</topic><topic>Polyomavirus Infections - immunology</topic><topic>Tumor Virus Infections - complications</topic><topic>Tumor Virus Infections - drug therapy</topic><topic>Tumor Virus Infections - immunology</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motte, Jeremias</creatorcontrib><creatorcontrib>Kneiphof, Janina</creatorcontrib><creatorcontrib>Straßburger-Krogias, Katrin</creatorcontrib><creatorcontrib>Klasing, Anja</creatorcontrib><creatorcontrib>Adams, Ortwin</creatorcontrib><creatorcontrib>Haghikia, Aiden</creatorcontrib><creatorcontrib>Gold, Ralf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motte, Jeremias</au><au>Kneiphof, Janina</au><au>Straßburger-Krogias, Katrin</au><au>Klasing, Anja</au><au>Adams, Ortwin</au><au>Haghikia, Aiden</au><au>Gold, Ralf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>265</volume><issue>8</issue><spage>1880</spage><epage>1882</epage><pages>1880-1882</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-JCV-antibody in CSF and serum were highly positive. Stratify®-JCV-test was positive. CD8-positive T-lymphocytes were reduced. Therapy with mefloquine, mirtazapine and cidofovir resulted in complete elimination of the virus in serum and 90% reduction of viral load in CSF. This case shows that despite careful monitoring for lymphopenia JCV spreading to the CSF may occur during treatment with DMF.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29948248</pmid><doi>10.1007/s00415-018-8931-7</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-6624-8565</orcidid></addata></record> |
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| subjects | Aged Antibodies, Viral - blood Antibodies, Viral - cerebrospinal fluid Archetypes CD8 antigen Cerebrospinal fluid Cidofovir Deoxyribonucleic acid Dimethyl Fumarate - therapeutic use DNA DNA, Viral - blood DNA, Viral - cerebrospinal fluid Encephalitis Female Humans Immunosuppressive Agents - therapeutic use JC Virus - genetics JC Virus - immunology Lymphocytes T Lymphopenia Medicine Medicine & Public Health Mefloquine Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - complications Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - immunology Neurology Neuroradiology Neurosciences Original Communication Patients Polyomavirus Infections - complications Polyomavirus Infections - drug therapy Polyomavirus Infections - immunology Tumor Virus Infections - complications Tumor Virus Infections - drug therapy Tumor Virus Infections - immunology Viral infections |
| title | Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML |
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