Influence of age on susceptibility to Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in Long-Evans rats

Epidemiological investigations suggest that increased age is associated with susceptibility to infection. Pseudomonas aeruginosa (P. aeruginosa) infection and associated exotoxin A (PEA) toxicity have been reported in hospitalized elderly patients and young children with cystic fibrosis. The present...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2009, Vol.71(2), pp.163-169
Hauptverfasser:	Chuang, H.L.(National Chung Hsing Univ., Taichung (Taiwan)), Huang, Y.T, Chiu, C.C, Chen, H.H.C, Chu, Y.Y, Chen, T.H
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - administration & dosage ADP Ribose Transferases - metabolism ADP Ribose Transferases - toxicity AGE Age Factors Analysis of Variance Animals Bacterial Toxins - administration & dosage Bacterial Toxins - metabolism Bacterial Toxins - toxicity CITOQUINAS CYTOKINE CYTOKINES Cytokines - analysis Disease Models, Animal EDAD EXOTOXINAS EXOTOXINE EXOTOXINS Exotoxins - administration & dosage Exotoxins - metabolism Exotoxins - toxicity FOIE HIGADO HISTOPATHOLOGIE HISTOPATHOLOGY HISTOPATOLOGIA In Situ Nick-End Labeling - methods In Situ Nick-End Labeling - veterinary Injections, Intravenous Kaplan-Meier Estimate LIVER Liver - drug effects Liver - pathology Male PCNA Proliferating Cell Nuclear Antigen PSEUDOMONAS AERUGINOSA Pseudomonas aeruginosa Exotoxin A Pseudomonas Infections - metabolism RAT RATA RATS Rats, Long-Evans TUNEL Virulence Factors - administration & dosage Virulence Factors - metabolism Virulence Factors - toxicity
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