Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 β-lactamase–producing Klebsiella pneumoniae epidemic clone

Abstract We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-β-lactamase (VIM-1) and an extended-spectrum β-lactamase (SHV-12). Time-kill studies demonstrated that...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2008-03, Vol.60 (3), p.319-322
Hauptverfasser:	Cobo, Javier, Morosini, María-Isabel, Pintado, Vicente, Tato, Marta, Samaranch, Noemí, Baquero, Fernando, Cantón, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - therapeutic use Bacteremia Bacteremia - drug therapy Bacterial diseases Bacterial sepsis Bacteriology beta-Lactamases - biosynthesis Biological and medical sciences Colistin - therapeutic use Drug Synergism Drug Therapy, Combination Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infectious Disease Infectious diseases Internal Medicine K. pneumoniae Klebsiella Infections - drug therapy Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Male Medical sciences Metallo-β-lactamase Microbial Sensitivity Tests Microbial Viability Microbiology Minocycline - analogs & derivatives Minocycline - therapeutic use Miscellaneous Tigecycline
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