Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 β-lactamase–producing Klebsiella pneumoniae epidemic clone
Abstract We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-β-lactamase (VIM-1) and an extended-spectrum β-lactamase (SHV-12). Time-kill studies demonstrated that...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2008-03, Vol.60 (3), p.319-322 |
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| container_title | Diagnostic microbiology and infectious disease |
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| creator | Cobo, Javier Morosini, María-Isabel Pintado, Vicente Tato, Marta Samaranch, Noemí Baquero, Fernando Cantón, Rafael |
| description | Abstract We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-β-lactamase (VIM-1) and an extended-spectrum β-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone. |
| doi_str_mv | 10.1016/j.diagmicrobio.2007.09.017 |
| format | Article |
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Psychology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>K. pneumoniae</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallo-β-lactamase</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbial Viability</subject><subject>Microbiology</subject><subject>Minocycline - analogs & derivatives</subject><subject>Minocycline - therapeutic use</subject><subject>Miscellaneous</subject><subject>Tigecycline</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkFu1DAUhiMEotPCFZCFBLsMz4kniVkgoVJoRRGL0m6tF_tl8JA4U9tBmh134AjcgINwCE6CoxkBYsXKkvW99z_9_59ljzksOfDq2WZpLK4Hq_3Y2nFZANRLkEvg9Z1swZta5ukH7mYLqMsibxpZHmXHIWwAeCEF3M-OeC1lJXi9yL5dB2Jjx6Jdk97p3jpi3ehZ_EgsesI4kIszsPVjP7o1GdaijuRpsMjMlKiRIRumPlpPwYaIib-5eJdzhs6wq_ObnBfsx_e8T2M4YKCfX76mZWbS1q3Z257aYKnvkW0dTcPoLBKjrTVJQDOdNOlBdq_DPtDDw3uSXb8--3B6nl--f3Nx-vIy10KKmJuWS42gqYOirFbYIsq61aKtykZSywmFEXW1MlCiXLVSUtUIDkLwqlgZDuVJ9nS_N513O1GIarBBz7c5GqegCqigrIVM4PM9mBIIwVOntt4O6HeKg5ojUhv1d0RqjkiBVCmiNPzooDK1A5k_o4dMEvDkAGDQ2HcenbbhN1cAXzVCNIl7tecoefLZkldBW3KaTEpCR2VG-3_3vPhnzdwCm5Q_0Y7CZpy8S64rrkKhQF3NpZo7lSqWvIOy_AXfdM8p</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Cobo, Javier</creator><creator>Morosini, María-Isabel</creator><creator>Pintado, Vicente</creator><creator>Tato, Marta</creator><creator>Samaranch, Noemí</creator><creator>Baquero, Fernando</creator><creator>Cantón, Rafael</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20080301</creationdate><title>Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 β-lactamase–producing Klebsiella pneumoniae epidemic clone</title><author>Cobo, Javier ; Morosini, María-Isabel ; Pintado, Vicente ; Tato, Marta ; Samaranch, Noemí ; Baquero, Fernando ; Cantón, Rafael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-db19ca0cef02365abaa97bc4b6389eb1ea4d4765d03a95b99e68410441625d103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteremia</topic><topic>Bacteremia - drug therapy</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Bacteriology</topic><topic>beta-Lactamases - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Colistin - therapeutic use</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0732-8893 |
| ispartof | Diagnostic microbiology and infectious disease, 2008-03, Vol.60 (3), p.319-322 |
| issn | 0732-8893 1879-0070 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Anti-Bacterial Agents - therapeutic use Bacteremia Bacteremia - drug therapy Bacterial diseases Bacterial sepsis Bacteriology beta-Lactamases - biosynthesis Biological and medical sciences Colistin - therapeutic use Drug Synergism Drug Therapy, Combination Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infectious Disease Infectious diseases Internal Medicine K. pneumoniae Klebsiella Infections - drug therapy Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Male Medical sciences Metallo-β-lactamase Microbial Sensitivity Tests Microbial Viability Microbiology Minocycline - analogs & derivatives Minocycline - therapeutic use Miscellaneous Tigecycline |
| title | Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 β-lactamase–producing Klebsiella pneumoniae epidemic clone |
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