Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice

While dopamine replacement remains the standard pharmacotherapy for Parkinson's disease, chronic L-dopa treatment is associated with development of debilitating motor fluctuations such as L-dopa-induced dyskinesia (LID). In this study we evaluated the effects of the partial dopamine D 2 agonist...

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Veröffentlicht in:	Behavioural brain research 2009-09, Vol.202 (2), p.232-237
Hauptverfasser:	Kalda, Anti, Herm, Laura, Rinken, Ago, Zharkovsky, Alexander, Chen, Jiang-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A 2A receptor antagonists Adenosine A2 Receptor Antagonists Animals Antiparkinson Agents - administration & dosage Antiparkinson Agents - adverse effects Behavioral psychophysiology Benzazepines - administration & dosage Biological and medical sciences Caffeine - administration & dosage Caffeine - analogs & derivatives Corpus Striatum - drug effects Dopamine Agonists - administration & dosage Dopamine partial agonists Drug Therapy, Combination Fundamental and applied biological sciences. Psychology Guanosine 5'-O-(3-Thiotriphosphate) - metabolism L-dopa-induced dyskinesia Levodopa - administration & dosage Levodopa - adverse effects Lisuride - administration & dosage Lisuride - analogs & derivatives Male Medical sciences Mice Mice, Inbred C57BL Motor Activity - drug effects Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Oxidopamine Parkinson Disease, Secondary - chemically induced Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Random Allocation Receptors, Dopamine D1 - agonists Receptors, Dopamine D2 - agonists Sulfur Radioisotopes Terguride
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