Low-cost LED-based Photo-CIDNP Enables Biocompatible Hyperpolarization of 19 F for NMR and MRI at 7 T and 4.7 T
Substrates containing F can serve as background-free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal-to-noise ratio (SNR) when compared with H NMR. Although hyperpolarization can increase the SNR, to date, only photo-chemically induced dyna...
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| Veröffentlicht in: | Chemphyschem 2018-10, Vol.19 (19), p.2453-2456 |
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| container_title | Chemphyschem |
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| creator | Bernarding, Johannes Euchner, Frederike Bruns, Christian Ringleb, Rainer Müller, Darius Trantzschel, Thomas Bargon, Joachim Bommerich, Ute Plaumann, Markus |
| description | Substrates containing
F can serve as background-free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal-to-noise ratio (SNR) when compared with
H NMR. Although hyperpolarization can increase the SNR, to date, only photo-chemically induced dynamic nuclear polarization (photo-CIDNP) allows for hyperpolarization without harmful metal catalysts. Photo-CIDNP was shown to significantly enhance
F NMR signals of 3-fluoro-DL-tyrosine in aqueous solution using flavins as photosensitizers. However, lasers were used for photoexcitation, which is expensive and requires appropriate protection procedures in a medical or lab environment. Herein, we report
F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low-cost and easy-to-handle LED-based set-up. First hyperpolarized
F MR images could be acquired, because photo-CIDNP enabled repetitive hyperpolarization without adding new substrates. |
| doi_str_mv | 10.1002/cphc.201800570 |
| format | Article |
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F can serve as background-free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal-to-noise ratio (SNR) when compared with
H NMR. Although hyperpolarization can increase the SNR, to date, only photo-chemically induced dynamic nuclear polarization (photo-CIDNP) allows for hyperpolarization without harmful metal catalysts. Photo-CIDNP was shown to significantly enhance
F NMR signals of 3-fluoro-DL-tyrosine in aqueous solution using flavins as photosensitizers. However, lasers were used for photoexcitation, which is expensive and requires appropriate protection procedures in a medical or lab environment. Herein, we report
F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low-cost and easy-to-handle LED-based set-up. First hyperpolarized
F MR images could be acquired, because photo-CIDNP enabled repetitive hyperpolarization without adding new substrates.</description><identifier>ISSN: 1439-4235</identifier><identifier>EISSN: 1439-7641</identifier><identifier>DOI: 10.1002/cphc.201800570</identifier><identifier>PMID: 29944199</identifier><language>eng</language><publisher>Germany</publisher><subject>Flavin Mononucleotide - chemistry ; Flavins - chemistry ; Fluorine - chemistry ; Lasers ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Tyrosine - analogs & derivatives ; Tyrosine - chemistry</subject><ispartof>Chemphyschem, 2018-10, Vol.19 (19), p.2453-2456</ispartof><rights>2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1409-c30df4a96d1f3db601745bcfed15c8a9e54a4f1a99f9712d889bd3052bc5f1803</citedby><cites>FETCH-LOGICAL-c1409-c30df4a96d1f3db601745bcfed15c8a9e54a4f1a99f9712d889bd3052bc5f1803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29944199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernarding, Johannes</creatorcontrib><creatorcontrib>Euchner, Frederike</creatorcontrib><creatorcontrib>Bruns, Christian</creatorcontrib><creatorcontrib>Ringleb, Rainer</creatorcontrib><creatorcontrib>Müller, Darius</creatorcontrib><creatorcontrib>Trantzschel, Thomas</creatorcontrib><creatorcontrib>Bargon, Joachim</creatorcontrib><creatorcontrib>Bommerich, Ute</creatorcontrib><creatorcontrib>Plaumann, Markus</creatorcontrib><title>Low-cost LED-based Photo-CIDNP Enables Biocompatible Hyperpolarization of 19 F for NMR and MRI at 7 T and 4.7 T</title><title>Chemphyschem</title><addtitle>Chemphyschem</addtitle><description>Substrates containing
F can serve as background-free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal-to-noise ratio (SNR) when compared with
H NMR. Although hyperpolarization can increase the SNR, to date, only photo-chemically induced dynamic nuclear polarization (photo-CIDNP) allows for hyperpolarization without harmful metal catalysts. Photo-CIDNP was shown to significantly enhance
F NMR signals of 3-fluoro-DL-tyrosine in aqueous solution using flavins as photosensitizers. However, lasers were used for photoexcitation, which is expensive and requires appropriate protection procedures in a medical or lab environment. Herein, we report
F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low-cost and easy-to-handle LED-based set-up. First hyperpolarized
F MR images could be acquired, because photo-CIDNP enabled repetitive hyperpolarization without adding new substrates.</description><subject>Flavin Mononucleotide - chemistry</subject><subject>Flavins - chemistry</subject><subject>Fluorine - chemistry</subject><subject>Lasers</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - chemistry</subject><issn>1439-4235</issn><issn>1439-7641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhS0EoqWwMiKPLAnXid3EI_RBK5VSVWWOHD_UoCQOcSpUJhb-KL-E9EGne-7ROWf4ELol4BOA4EFWa-kHQGIAFsEZ6hIaci_qU3J-1DQIWQddOfcOADFE5BJ1As4pJZx3kZvZT09a1-DZaOilwmmFF2vbWG8wHc4XeFSKNNcOP2VW2qISTda-eLKtdF3ZXNTZV2vZEluDCcdjbGyN5y9LLEqFX5ZTLBoc_X7_rPYG9ff6Gl0YkTt9c7w99DYerQYTb_b6PB08zjxJKHBPhqAMFbyviAlV2gcSUZZKoxVhMhZcMyqoIYJzwyMSqDjmqQqBBalkpgUS9tD9Ybeq7cdGuyYpMid1notS241LAmCcRSyku6h_iMraOldrk1R1Voh6mxBIdqCTHejkBLot3B23N2mh1Sn-Tzb8A1jzeBM</recordid><startdate>20181005</startdate><enddate>20181005</enddate><creator>Bernarding, Johannes</creator><creator>Euchner, Frederike</creator><creator>Bruns, Christian</creator><creator>Ringleb, Rainer</creator><creator>Müller, Darius</creator><creator>Trantzschel, Thomas</creator><creator>Bargon, Joachim</creator><creator>Bommerich, Ute</creator><creator>Plaumann, Markus</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181005</creationdate><title>Low-cost LED-based Photo-CIDNP Enables Biocompatible Hyperpolarization of 19 F for NMR and MRI at 7 T and 4.7 T</title><author>Bernarding, Johannes ; Euchner, Frederike ; Bruns, Christian ; Ringleb, Rainer ; Müller, Darius ; Trantzschel, Thomas ; Bargon, Joachim ; Bommerich, Ute ; Plaumann, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1409-c30df4a96d1f3db601745bcfed15c8a9e54a4f1a99f9712d889bd3052bc5f1803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Flavin Mononucleotide - chemistry</topic><topic>Flavins - chemistry</topic><topic>Fluorine - chemistry</topic><topic>Lasers</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernarding, Johannes</creatorcontrib><creatorcontrib>Euchner, Frederike</creatorcontrib><creatorcontrib>Bruns, Christian</creatorcontrib><creatorcontrib>Ringleb, Rainer</creatorcontrib><creatorcontrib>Müller, Darius</creatorcontrib><creatorcontrib>Trantzschel, Thomas</creatorcontrib><creatorcontrib>Bargon, Joachim</creatorcontrib><creatorcontrib>Bommerich, Ute</creatorcontrib><creatorcontrib>Plaumann, Markus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemphyschem</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernarding, Johannes</au><au>Euchner, Frederike</au><au>Bruns, Christian</au><au>Ringleb, Rainer</au><au>Müller, Darius</au><au>Trantzschel, Thomas</au><au>Bargon, Joachim</au><au>Bommerich, Ute</au><au>Plaumann, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-cost LED-based Photo-CIDNP Enables Biocompatible Hyperpolarization of 19 F for NMR and MRI at 7 T and 4.7 T</atitle><jtitle>Chemphyschem</jtitle><addtitle>Chemphyschem</addtitle><date>2018-10-05</date><risdate>2018</risdate><volume>19</volume><issue>19</issue><spage>2453</spage><epage>2456</epage><pages>2453-2456</pages><issn>1439-4235</issn><eissn>1439-7641</eissn><abstract>Substrates containing
F can serve as background-free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal-to-noise ratio (SNR) when compared with
H NMR. Although hyperpolarization can increase the SNR, to date, only photo-chemically induced dynamic nuclear polarization (photo-CIDNP) allows for hyperpolarization without harmful metal catalysts. Photo-CIDNP was shown to significantly enhance
F NMR signals of 3-fluoro-DL-tyrosine in aqueous solution using flavins as photosensitizers. However, lasers were used for photoexcitation, which is expensive and requires appropriate protection procedures in a medical or lab environment. Herein, we report
F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low-cost and easy-to-handle LED-based set-up. First hyperpolarized
F MR images could be acquired, because photo-CIDNP enabled repetitive hyperpolarization without adding new substrates.</abstract><cop>Germany</cop><pmid>29944199</pmid><doi>10.1002/cphc.201800570</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Flavin Mononucleotide - chemistry Flavins - chemistry Fluorine - chemistry Lasers Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Tyrosine - analogs & derivatives Tyrosine - chemistry |
| title | Low-cost LED-based Photo-CIDNP Enables Biocompatible Hyperpolarization of 19 F for NMR and MRI at 7 T and 4.7 T |
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