Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population

We investigated ethnicity-specific exonic variants of type 2 diabetes (T2D) and its related clinical phenotypes in an East Asian population. We performed whole-exome sequencing in 917 T2D case and control subjects, and the findings were validated by exome array genotyping in 3,026 participants. In s...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2018-09, Vol.67 (9), p.1892-1902
Hauptverfasser:	Kwak, Soo Heon, Chae, Jeesoo, Lee, Seungbok, Choi, Sungkyoung, Koo, Bo Kyung, Yoon, Ji Won, Park, Jin-Ho, Cho, Belong, Moon, Min Kyong, Lim, Soo, Cho, Young Min, Moon, Sanghoon, Kim, Young Jin, Han, Sohee, Hwang, Mi Yeong, Cho, Yoon Shin, Lee, Myung-Shik, Jang, Hak C, Kang, Hyun Min, Park, Taesung, Cho, Nam H, Kim, Kyunga, Kim, Jong-Il, Park, Kyong Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Amino Acid Substitution Asian Continental Ancestry Group Cardiovascular diseases Cardiovascular system Case-Control Studies Cohort Studies Computational Biology Databases, Genetic Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Disease prevention Expert Systems Fasting Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Genomes Genotype & phenotype Genotyping Glucagon-Like Peptide-1 Receptor - chemistry Glucagon-Like Peptide-1 Receptor - genetics Glucagon-Like Peptide-1 Receptor - metabolism Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Laboratory testing Male Middle Aged Minority & ethnic groups Paired Box Transcription Factors - chemistry Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Phenotypes Polymorphism, Single Nucleotide Population genetics Republic of Korea Whole Exome Sequencing
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