Pharmacokinetic profiles of metamizole (dipyrone) active metabolites in goats and its residues in milk

Metamizole (dipyrone, MET) is a nonopioid analgesic drug commonly used in human and veterinary medicine. The aim of this study was to assess two major active metabolites of MET, 4‐methylaminoantipyrin (MAA) and 4‐aminoantipyrin (AA), in goat plasma after intravenous (IV) and intramuscular (IM) admin...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2018-10, Vol.41 (5), p.699-705
Hauptverfasser:	Kim, Tae Won, Łebkowska‐Wieruszewska, Beata, Sitovs, Andrejs, Poapolathep, Amnart, Owen, Helen, Lisowski, Andrzej, Abilova, Zulkyya, Giorgi, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampyrone - analysis Analgesics - analysis Analgesics - pharmacokinetics Animals Antipyrine - analogs & derivatives Antipyrine - analysis dipyrone Dipyrone - analysis Dipyrone - pharmacokinetics Drug Residues - analysis Female goat Goats - metabolism Injections, Intramuscular - veterinary Injections, Intravenous - veterinary metabolite metamizole Milk - chemistry pharmacokinetics residue
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