Enhancement of cell death by TNF alpha-related apoptosis-inducing ligand (TRAIL) in human lung carcinoma A549 cells exposed to x rays under hypoxia

Our previous study showed that ionizing radiation induced the expression of death receptor DR5 on the cell surface in tumor cell lines and that the death receptor of the TNF alpha-related apoptosis-inducing ligand TRAIL enhanced the apoptotic pathway (Hamasu et al., (2005) Journal of Radiation Resea...

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Veröffentlicht in:	Journal of radiation research 2007-11, Vol.48 (6), p.461-468
Hauptverfasser:	Takahashi, Momoko, Inanami, Osamu, Kubota, Nobuo, Tsujitani, Michihiko, Yasui, Hironobu, Ogura, Aki, Kuwabara, Mikinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - radiation effects Cell Hypoxia - drug effects Cell Hypoxia - radiation effects Cell Line, Tumor Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Oxygen - metabolism Radiation Tolerance - drug effects Receptors, TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors TNF-Related Apoptosis-Inducing Ligand - administration & dosage Tumor Necrosis Factor-alpha - metabolism X-Rays
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