Dexamethasone suppresses interleukin-1β-induced human β-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-κB transcriptional factor in A549 cells

Human β-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity. Glucocorticoids, on the other hand, exert immunosuppressive and anti-inflammatory actions. We have previously reported that interleukin (IL)-1β induces HBD-2 mRNA expression through the ac...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2007-10, Vol.51 (1), p.171-184
Hauptverfasser:	Jang, Byeong-Churl, Lim, Ki-Jo, Suh, Min-Ho, Park, Jong-Gu, Suh, Seong-Il
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Antimicrobial peptides Bacteriology Biological and medical sciences c-Jun protein Cytokines Deactivation defensin Defensins Dexamethasone Fundamental and applied biological sciences. Psychology Gene expression Glucocorticoids IL-1β Inactivation Inflammation Innate immunity Interleukins JNK protein Kinases MAP kinase MAP kinase phosphatase Microbiology MKP-1 NF-κB NF-κB protein Nuclear transport p38 MAPK Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Protein kinase Steroids Transcription activation Transcription factors Translocation
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