Activity of 8.O.4'-neolignans against Trypanosoma cruzi
The in vitro evaluation of a series of 8.O.4'-neolignans (in their ketone, alcohol, and acetylated forms) on the proliferation of Trypanosoma cruzi led to the detection of three compounds with interesting activities against T. cruzi epimastigotes. These compounds also inhibited the in vitro dif...
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| Veröffentlicht in: | Parasitology research (1987) 2007-10, Vol.101 (5), p.1453-1457 |
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| container_title | Parasitology research (1987) |
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| creator | Nocito, Isabel Castelli, María Victoria Zacchino, Susana A Serra, Esteban |
| description | The in vitro evaluation of a series of 8.O.4'-neolignans (in their ketone, alcohol, and acetylated forms) on the proliferation of Trypanosoma cruzi led to the detection of three compounds with interesting activities against T. cruzi epimastigotes. These compounds also inhibited the in vitro differentiation of epimastigotes to trypomastigotes. When tested against HeLa cells, the same compounds did not affect the cell vitality and showed a low influence on cell viability as measured by dimethylthiazol diphenyltetrazolium bromide reduction. The three phenylpropanoid moieties tested did not show any activity against T. cruzi. One of the tested compounds, compound 4 (3,4-methylenedioxi7-oxo-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan) showed the best performance in both trypanocide and cytotoxic assays, suggesting that it should be considered as a leading structure for further research. |
| doi_str_mv | 10.1007/s00436-007-0657-x |
| format | Article |
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These compounds also inhibited the in vitro differentiation of epimastigotes to trypomastigotes. When tested against HeLa cells, the same compounds did not affect the cell vitality and showed a low influence on cell viability as measured by dimethylthiazol diphenyltetrazolium bromide reduction. The three phenylpropanoid moieties tested did not show any activity against T. cruzi. 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These compounds also inhibited the in vitro differentiation of epimastigotes to trypomastigotes. When tested against HeLa cells, the same compounds did not affect the cell vitality and showed a low influence on cell viability as measured by dimethylthiazol diphenyltetrazolium bromide reduction. The three phenylpropanoid moieties tested did not show any activity against T. cruzi. One of the tested compounds, compound 4 (3,4-methylenedioxi7-oxo-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan) showed the best performance in both trypanocide and cytotoxic assays, suggesting that it should be considered as a leading structure for further research.</description><subject>Animals</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. 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Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>HeLa Cells - drug effects</topic><topic>Humans</topic><topic>Invertebrates</topic><topic>Lignans - pharmacology</topic><topic>Lignans - toxicity</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - drug effects</topic><topic>Trypanosoma cruzi - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nocito, Isabel</creatorcontrib><creatorcontrib>Castelli, María Victoria</creatorcontrib><creatorcontrib>Zacchino, Susana A</creatorcontrib><creatorcontrib>Serra, Esteban</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nocito, Isabel</au><au>Castelli, María Victoria</au><au>Zacchino, Susana A</au><au>Serra, Esteban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity of 8.O.4'-neolignans against Trypanosoma cruzi</atitle><jtitle>Parasitology research (1987)</jtitle><addtitle>Parasitol Res</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>101</volume><issue>5</issue><spage>1453</spage><epage>1457</epage><pages>1453-1457</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>The in vitro evaluation of a series of 8.O.4'-neolignans (in their ketone, alcohol, and acetylated forms) on the proliferation of Trypanosoma cruzi led to the detection of three compounds with interesting activities against T. cruzi epimastigotes. These compounds also inhibited the in vitro differentiation of epimastigotes to trypomastigotes. When tested against HeLa cells, the same compounds did not affect the cell vitality and showed a low influence on cell viability as measured by dimethylthiazol diphenyltetrazolium bromide reduction. The three phenylpropanoid moieties tested did not show any activity against T. cruzi. One of the tested compounds, compound 4 (3,4-methylenedioxi7-oxo-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan) showed the best performance in both trypanocide and cytotoxic assays, suggesting that it should be considered as a leading structure for further research.</abstract><cop>Berlin</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>17703322</pmid><doi>10.1007/s00436-007-0657-x</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antiprotozoal Agents - pharmacology Biological and medical sciences Cell Survival Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models HeLa Cells - drug effects Humans Invertebrates Lignans - pharmacology Lignans - toxicity Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - growth & development |
| title | Activity of 8.O.4'-neolignans against Trypanosoma cruzi |
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